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Carl H. June
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Journal Articles

Identification of Core Techniques That Enhance Genome Editing of Human T Cells Expressing Synthetic Antigen Receptors

Ju-Fang Chang, Nils Wellhausen, Nils W. Engel, Jack H. Landmann, Caitlin R. Hopkins, January Salas-McKee, Adham S. Bear, Mehmet E. Selli, Sangya Agarwal, Julie K. Jadlowsky, Gerald P. Linette, Saar Gill, Carl H. June, Joseph A. Fraietta, Nathan Singh
Journal: Cancer Immunology Research
Cancer Immunol Res (2024) 12 (9): 1136–1146.
https://doi.org/10.1158/2326-6066.CIR-24-0251
Published: 03 September 2024
View article titled, Identification of Core Techniques That Enhance Genome Editing of Human T Cells Expressing Synthetic Antigen Receptors
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Includes: Supplementary data
Journal Articles

Regulatory Considerations for Genome-Edited T-cell Therapies

Julie K. Jadlowsky, Ju-fang Chang, David H. Spencer, John M. Warrington, Bruce L. Levine, Carl H. June, Joseph A. Fraietta, Nathan Singh
Journal: Cancer Immunology Research
Cancer Immunol Res (2024) 12 (9): 1132–1135.
https://doi.org/10.1158/2326-6066.CIR-24-0482
Published: 03 September 2024
View article titled, Regulatory Considerations for Genome-Edited T-cell Therapies
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Journal Articles

Sequential Exposure to IL21 and IL15 During Human Natural Killer Cell Expansion Optimizes Yield and Function

Caimei Zhang, Siddhant Kadu, Yansen Xiao, Omar Johnson, Andre Kelly, Roddy S. O'Connor, Meizan Lai, Hong Kong, Sriram Srivatsa, Victoria Tai, Eli Greenblatt, Matthew Holmes, James L. Riley, Carl H. June, Neil C. Sheppard
Journal: Cancer Immunology Research
Cancer Immunol Res (2023) 11 (11): 1524–1537.
https://doi.org/10.1158/2326-6066.CIR-23-0151
Published: 01 November 2023
View article titled, Sequential Exposure to IL21 and IL15 During Human Natural Killer Cell Expansion Optimizes Yield and Function
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Includes: Supplementary data
Journal Articles

T-cell Therapies Targeting Multiple Cancer Antigens: The Power of Many

Ugur Uslu, Carl H. June
Journal: Cancer Immunology Research
Cancer Immunol Res (2023) 11 (7): 865.
https://doi.org/10.1158/2326-6066.CIR-23-0160
Published: 05 July 2023
View article titled, T-cell Therapies Targeting Multiple Cancer Antigens: The Power of Many
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Journal Articles

Abstract B19: FAP CAR T cell therapy for solid tumors with PET imaging

Estela Noguera-Ortega, Iris K Lee, Zebin Xiao, Leslie Todd, John Scholler, Decheng Song, Maria Liousia, Katheryn Lohith, Kexiang Xu, Kimberly J Eduards, Michael D Farwell, Carl H June, Steven M Albelda, Ellen Puré, Mark A Sellmyer
Journal: Cancer Immunology Research
Cancer Immunol Res (2022) 10 (12_Supplement): B19.
https://doi.org/10.1158/2326-6074.TUMIMM22-B19
Published: 01 December 2022
View article titled, Abstract B19: FAP CAR T cell therapy for solid tumors with PET imaging
Journal Articles

Abstract A123: Skewed CD4 and CD8 T-cell differentiation in pancreatic cancer patients

Cecile Alanio, Bertram Bengsch, Josephine R. Gies, Sarah Henrickson, Nan Ping Weng, Janáe A Ritz-Romeo, Mark O'Hara, Joseph J Melenhorst, Simon Lacey, Regina M Young, Carl H June, E. John Wherry
Journal: Cancer Immunology Research
Cancer Immunol Res (2019) 7 (2_Supplement): A123.
https://doi.org/10.1158/2326-6074.CRICIMTEATIAACR18-A123
Published: 01 February 2019
View article titled, Abstract A123: Skewed CD4 and CD8 T-cell differentiation in pancreatic cancer patients
Journal Articles

Reducing Ex Vivo Culture Improves the Antileukemic Activity of Chimeric Antigen Receptor (CAR) T Cells

Saba Ghassemi, Selene Nunez-Cruz, Roddy S. O'Connor, Joseph A. Fraietta, Prachi R. Patel, John Scholler, David M. Barrett, Stefan M. Lundh, Megan M. Davis, Felipe Bedoya, Changfeng Zhang, John Leferovich, Simon F. Lacey, Bruce L. Levine, Stephan A. Grupp, Carl H. June, J. Joseph Melenhorst, Michael C. Milone
Journal: Cancer Immunology Research
Cancer Immunol Res (2018) 6 (9): 1100–1109.
https://doi.org/10.1158/2326-6066.CIR-17-0405
Published: 04 September 2018
View article titled, Reducing <em>Ex Vivo</em> Culture Improves the Antileukemic Activity of Chimeric Antigen Receptor (CAR) T Cells
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Includes: Supplementary data
Journal Articles

Abstract IA20: Updates on CAR T Cells

Carl H. June, John Scholler, Marco Ruella, Joseph Fraietta, J. Jos Melenhorst, Jiangtao Ren, Yangbing Zhao
Journal: Cancer Immunology Research
Cancer Immunol Res (2018) 6 (9_Supplement): IA20.
https://doi.org/10.1158/2326-6074.TUMIMM17-IA20
Published: 01 September 2018
View article titled, Abstract IA20: Updates on CAR T Cells
Journal Articles

Improving CART-Cell Therapy of Solid Tumors with Oncolytic Virus–Driven Production of a Bispecific T-cell Engager

Anna Wing, Carlos Alberto Fajardo, Avery D. Posey, Jr, Carolyn Shaw, Tong Da, Regina M. Young, Ramon Alemany, Carl H. June, Sonia Guedan
Journal: Cancer Immunology Research
Series: Author Choice
Cancer Immunol Res (2018) 6 (5): 605–616.
https://doi.org/10.1158/2326-6066.CIR-17-0314
Published: 30 April 2018
View article titled, Improving CART-Cell Therapy of Solid Tumors with Oncolytic Virus–Driven Production of a Bispecific T-cell Engager
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Includes: Supplementary data
Journal Articles

Safety and Efficacy of Intratumoral Injections of Chimeric Antigen Receptor (CAR) T Cells in Metastatic Breast Cancer

Julia Tchou, Yangbing Zhao, Bruce L. Levine, Paul J Zhang, Megan M. Davis, Jan Joseph Melenhorst, Irina Kulikovskaya, Andrea L Brennan, Xiaojun Liu, Simon F. Lacey, Avery D. Posey, Jr., Austin D. Williams, Alycia So, Jose R. Conejo-Garcia, Gabriela Plesa, Regina M. Young, Shannon McGettigan, Jean Campbell, Robert H. Pierce, Jennifer M. Matro, Angela M. DeMichele, Amy S. Clark, Laurence J. Cooper, Lynn M. Schuchter, Robert H. Vonderheide, Carl H. June
Journal: Cancer Immunology Research
Series: Author Choice
Cancer Immunol Res (2017) 5 (12): 1152–1161.
https://doi.org/10.1158/2326-6066.CIR-17-0189
Published: 30 November 2017
View article titled, Safety and Efficacy of Intratumoral Injections of Chimeric Antigen Receptor (CAR) T Cells in Metastatic Breast Cancer
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Includes: Supplementary data
Journal Articles

Remote Controlled CARs: Towards a Safer Therapy for Leukemia

Carl H. June
Journal: Cancer Immunology Research
Cancer Immunol Res (2016) 4 (8): 643.
https://doi.org/10.1158/2326-6066.CIR-16-0132
Published: 31 July 2016
View article titled, Remote Controlled CARs: Towards a Safer Therapy for Leukemia
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Journal Articles

Abstract B139: Toxicity testing of EGFRvIII CAR-based immunotherapy of glioblastoma: From bench to bedside

Alexandria P. Cogdill, Alina Boesteanu, Chong Xu, Kathleen Haines, John Scholler, Joseph Fraietta, Yangbing Zhao, Xiaojun Liu, Jennifer Morrissette, Bruce Levine, Simon Lacey, Andreas Loew, Reshma Singh, Jennifer Brogdon, Donald M. O'Rourke, Marcela V. Maus, Carl H. June, Laura A. Johnson
Journal: Cancer Immunology Research
Cancer Immunol Res (2016) 4 (1_Supplement): B139.
https://doi.org/10.1158/2326-6074.CRICIMTEATIAACR15-B139
Published: 03 January 2016
View article titled, Abstract B139: Toxicity testing of EGFRvIII CAR-based immunotherapy of glioblastoma: From bench to bedside
Journal Articles

Serial Killers and Mass Murderers: Engineered T Cells Are up to the Task

Carl H. June
Journal: Cancer Immunology Research
Cancer Immunol Res (2015) 3 (5): 470–472.
https://doi.org/10.1158/2326-6066.CIR-15-0075
Published: 03 May 2015
View article titled, Serial Killers and Mass Murderers: Engineered T Cells Are up to the Task
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Journal Articles

Identification of Chimeric Antigen Receptors That Mediate Constitutive or Inducible Proliferation of T Cells

Matthew J. Frigault, Jihyun Lee, Maria Ciocca Basil, Carmine Carpenito, Shinichiro Motohashi, John Scholler, Omkar U. Kawalekar, Sonia Guedan, Shannon E. McGettigan, Avery D. Posey, Jr, Sonny Ang, Laurence J.N. Cooper, Jesse M. Platt, F. Brad Johnson, Chrystal M. Paulos, Yangbing Zhao, Michael Kalos, Michael C. Milone, Carl H. June
Journal: Cancer Immunology Research
Cancer Immunol Res (2015) 3 (4): 356–367.
https://doi.org/10.1158/2326-6066.CIR-14-0186
Published: 05 April 2015
View article titled, Identification of Chimeric Antigen Receptors That Mediate Constitutive or Inducible Proliferation of T Cells
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Includes: Supplementary data
Journal Articles

Nature of Tumor Control by Permanently and Transiently Modified GD2 Chimeric Antigen Receptor T Cells in Xenograft Models of Neuroblastoma

Nathan Singh, Xiaojun Liu, Jessica Hulitt, Shuguang Jiang, Carl H. June, Stephan A. Grupp, David M. Barrett, Yangbing Zhao
Journal: Cancer Immunology Research
Series: Author Choice
Cancer Immunol Res (2014) 2 (11): 1059–1070.
https://doi.org/10.1158/2326-6066.CIR-14-0051
Published: 02 November 2014
View article titled, Nature of Tumor Control by Permanently and Transiently Modified GD2 Chimeric Antigen Receptor T Cells in Xenograft Models of Neuroblastoma
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Includes: Supplementary data
Journal Articles

Mesothelin-Specific Chimeric Antigen Receptor mRNA-Engineered T Cells Induce Antitumor Activity in Solid Malignancies

Gregory L. Beatty, Andrew R. Haas, Marcela V. Maus, Drew A. Torigian, Michael C. Soulen, Gabriela Plesa, Anne Chew, Yangbing Zhao, Bruce L. Levine, Steven M. Albelda, Michael Kalos, Carl H. June
Journal: Cancer Immunology Research
Cancer Immunol Res (2014) 2 (2): 112–120.
https://doi.org/10.1158/2326-6066.CIR-13-0170
Published: 03 February 2014
View article titled, Mesothelin-Specific Chimeric Antigen Receptor mRNA-Engineered T Cells Induce Antitumor Activity in Solid Malignancies
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Includes: Supplementary data
Journal Articles

Targeting Fibroblast Activation Protein in Tumor Stroma with Chimeric Antigen Receptor T Cells Can Inhibit Tumor Growth and Augment Host Immunity without Severe Toxicity

Liang-Chuan S. Wang, Albert Lo, John Scholler, Jing Sun, Rajrupa S. Majumdar, Veena Kapoor, Michael Antzis, Cody E. Cotner, Laura A. Johnson, Amy C. Durham, Charalambos C. Solomides, Carl H. June, Ellen Puré, Steven M. Albelda
Journal: Cancer Immunology Research
Cancer Immunol Res (2014) 2 (2): 154–166.
https://doi.org/10.1158/2326-6066.CIR-13-0027
Published: 03 February 2014
View article titled, Targeting Fibroblast Activation Protein in Tumor Stroma with Chimeric Antigen Receptor T Cells Can Inhibit Tumor Growth and Augment Host Immunity without Severe Toxicity
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Includes: Supplementary data
Journal Articles

T Cells Expressing Chimeric Antigen Receptors Can Cause Anaphylaxis in Humans

Marcela V. Maus, Andrew R. Haas, Gregory L. Beatty, Steven M. Albelda, Bruce L. Levine, Xiaojun Liu, Yangbing Zhao, Michael Kalos, Carl H. June
Journal: Cancer Immunology Research
Cancer Immunol Res (2013) 1 (1): 26–31.
https://doi.org/10.1158/2326-6066.CIR-13-0006
Published: 10 July 2013
View article titled, T Cells Expressing Chimeric Antigen Receptors Can Cause Anaphylaxis in Humans
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Journal Articles

Chimeric Antigen Receptor T Cells with Dissociated Signaling Domains Exhibit Focused Antitumor Activity with Reduced Potential for Toxicity In Vivo

Evripidis Lanitis, Mathilde Poussin, Alex W. Klattenhoff, Degang Song, Raphael Sandaltzopoulos, Carl H. June, Daniel J. Powell, Jr
Journal: Cancer Immunology Research
Cancer Immunol Res (2013) 1 (1): 43–53.
https://doi.org/10.1158/2326-6066.CIR-13-0008
Published: 10 July 2013
View article titled, Chimeric Antigen Receptor T Cells with Dissociated Signaling Domains Exhibit Focused Antitumor Activity with Reduced Potential for Toxicity <em>In Vivo</em>
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Includes: Supplementary data