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Alfred Zippelius
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Journal Articles

Targeting cancer-associated glycosylation for adoptive T cell therapy of solid tumors

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Andreas Zingg, Reto Ritschard, Helen Thut, Mélanie Buchi, Andreas Holbro, Anton Oseledchyk, Viola Heinzelmann, Andreas Buser, Mascha Binder, Alfred Zippelius, Natalia Rodrigues Mantuano, Matthias Matter, Heinz Läubli
Journal: Cancer Immunology Research
Cancer Immunol Res (2025)
https://doi.org/10.1158/2326-6066.CIR-24-1050
Published: 16 April 2025
View articletitled, Targeting cancer-associated glycosylation for adoptive T cell therapy of solid tumors
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Includes: Supplementary data
Journal Articles

Melanoma Clonal Heterogeneity Leads to Secondary Resistance after Adoptive Cell Therapy with Tumor-Infiltrating Lymphocytes

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David König, Michael T. Sandholzer, Sarp Uzun, Andreas Zingg, Reto Ritschard, Helen Thut, Katharina Glatz, Elisabeth A. Kappos, Dirk J. Schaefer, Christoph Kettelhack, Jakob R. Passweg, Andreas Holbro, Katharina Baur, Michael Medinger, Andreas Buser, Didier Lardinois, Lukas T. Jeker, Nina Khanna, Frank Stenner, Benjamin Kasenda, Krisztian Homicsko, Matthias Matter, Natalia Rodrigues Mantuano, Alfred Zippelius, Heinz Läubli
Journal: Cancer Immunology Research
Cancer Immunol Res (2024) 12 (7): 814–821.
https://doi.org/10.1158/2326-6066.CIR-23-0757
Published: 02 July 2024
View articletitled, Melanoma Clonal Heterogeneity Leads to Secondary Resistance after Adoptive Cell Therapy with Tumor-Infiltrating Lymphocytes
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Includes: Supplementary data
Journal Articles

Hyperglycemia Enhances Cancer Immune Evasion by Inducing Alternative Macrophage Polarization through Increased O-GlcNAcylation

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Natália Rodrigues Mantuano, Michal A. Stanczak, Isadora de Araújo Oliveira, Nicole Kirchhammer, Alessandra A. Filardy, Gianni Monaco, Ronan Christian Santos, Agatha Carlos Fonseca, Miguel Fontes, César de Souza Bastos, Jr, Wagner B. Dias, Alfred Zippelius, Adriane R. Todeschini, Heinz Läubli
Journal: Cancer Immunology Research
Cancer Immunol Res (2020) 8 (10): 1262–1272.
https://doi.org/10.1158/2326-6066.CIR-19-0904
Published: 01 October 2020
View articletitled, Hyperglycemia Enhances Cancer Immune Evasion by Inducing Alternative Macrophage Polarization through Increased O-GlcNAcylation
Open the PDF for Hyperglycemia Enhances Cancer Immune Evasion by Inducing Alternative Macrophage Polarization through Increased O-GlcNAcylation in another window
Includes: Supplementary data
Journal Articles

Siglec-9 Regulates an Effector Memory CD8+ T-cell Subset That Congregates in the Melanoma Tumor Microenvironment

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Quentin Haas, Kayluz Frias Boligan, Camilla Jandus, Christoph Schneider, Cedric Simillion, Michal A. Stanczak, Monika Haubitz, Seyed Morteza Seyed Jafari, Alfred Zippelius, Gabriela M. Baerlocher, Heinz Läubli, Robert E. Hunger, Pedro Romero, Hans-Uwe Simon, Stephan von Gunten
Journal: Cancer Immunology Research
Series: Author Choice
Cancer Immunol Res (2019) 7 (5): 707–718.
https://doi.org/10.1158/2326-6066.CIR-18-0505
Published: 01 May 2019
View articletitled, Siglec-9 Regulates an Effector Memory CD8+ T-cell Subset That Congregates in the Melanoma Tumor Microenvironment
Open the PDF for Siglec-9 Regulates an Effector Memory CD8+ T-cell Subset That Congregates in the Melanoma Tumor Microenvironment in another window
Includes: Supplementary data
Journal Articles

Abstract B050: Identification of PD-1T TILs and CXCL13 as determinants for response to anti-PD-1 treatment using human tumor explants

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Daniela S. Thommen, Viktor H. Koelzer, Petra Herzig, Marjolein de Bruijn, Paula Voabil, Marlous van den Braber, Karlijn Hummelink, Kim Monkhorst, Kirsten D. Mertz, Alfred Zippelius, John B.A.G. Haanen, Ton N.M. Schumacher
Journal: Cancer Immunology Research
Cancer Immunol Res (2019) 7 (2_Supplement): B050.
https://doi.org/10.1158/2326-6074.CRICIMTEATIAACR18-B050
Published: 01 February 2019
View articletitled, Abstract B050: Identification of PD-1T TILs and CXCL13 as determinants for response to anti-PD-1 treatment using human tumor explants
Journal Articles

Local Tumor Treatment in Combination with Systemic Ipilimumab Immunotherapy Prolongs Overall Survival in Patients with Advanced Malignant Melanoma

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Sebastian Theurich, Sacha I. Rothschild, Michael Hoffmann, Mario Fabri, Andrea Sommer, Maria Garcia-Marquez, Martin Thelen, Catherine Schill, Ramona Merki, Thomas Schmid, Dieter Koeberle, Alfred Zippelius, Christian Baues, Cornelia Mauch, Christian Tigges, Alexander Kreuter, Jan Borggrefe, Michael von Bergwelt-Baildon, Max Schlaak
Journal: Cancer Immunology Research
Cancer Immunol Res (2016) 4 (9): 744–754.
https://doi.org/10.1158/2326-6066.CIR-15-0156
Published: 01 September 2016
View articletitled, Local Tumor Treatment in Combination with Systemic Ipilimumab Immunotherapy Prolongs Overall Survival in Patients with Advanced Malignant Melanoma
Open the PDF for Local Tumor Treatment in Combination with Systemic Ipilimumab Immunotherapy Prolongs Overall Survival in Patients with Advanced Malignant Melanoma in another window
Journal Articles

Progression of Lung Cancer Is Associated with Increased Dysfunction of T Cells Defined by Coexpression of Multiple Inhibitory Receptors

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Daniela S. Thommen, Jens Schreiner, Philipp Müller, Petra Herzig, Andreas Roller, Anton Belousov, Pablo Umana, Pavel Pisa, Christian Klein, Marina Bacac, Ozana S. Fischer, Wolfgang Moersig, Spasenija Savic Prince, Victor Levitsky, Vaios Karanikas, Didier Lardinois, Alfred Zippelius
Journal: Cancer Immunology Research
Series: Author Choice
Cancer Immunol Res (2015) 3 (12): 1344–1355.
https://doi.org/10.1158/2326-6066.CIR-15-0097
Published: 06 December 2015
View articletitled, Progression of Lung Cancer Is Associated with Increased Dysfunction of T Cells Defined by Coexpression of Multiple Inhibitory Receptors
Open the PDF for Progression of Lung Cancer Is Associated with Increased Dysfunction of T Cells Defined by Coexpression of Multiple Inhibitory Receptors in another window
Includes: Supplementary data
Journal Articles

Induced PD-L1 Expression Mediates Acquired Resistance to Agonistic Anti-CD40 Treatment

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Alfred Zippelius, Jens Schreiner, Petra Herzig, Philipp Müller
Journal: Cancer Immunology Research
Series: Author Choice
Cancer Immunol Res (2015) 3 (3): 236–244.
https://doi.org/10.1158/2326-6066.CIR-14-0226
Published: 02 March 2015
View articletitled, Induced PD-L1 Expression Mediates Acquired Resistance to Agonistic Anti-CD40 Treatment
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Includes: Supplementary data
Journal Articles

Microtubule-Depolymerizing Agents Used in Antibody–Drug Conjugates Induce Antitumor Immunity by Stimulation of Dendritic Cells

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Philipp Müller, Kea Martin, Sebastian Theurich, Jens Schreiner, Spasenija Savic, Grzegorz Terszowski, Didier Lardinois, Viola A. Heinzelmann-Schwarz, Max Schlaak, Hans-Michael Kvasnicka, Giulio Spagnoli, Stephan Dirnhofer, Daniel E. Speiser, Michael von Bergwelt-Baildon, Alfred Zippelius
Journal: Cancer Immunology Research
Series: Author Choice
Cancer Immunol Res (2014) 2 (8): 741–755.
https://doi.org/10.1158/2326-6066.CIR-13-0198
Published: 03 August 2014
View articletitled, Microtubule-Depolymerizing Agents Used in Antibody–Drug Conjugates Induce Antitumor Immunity by Stimulation of Dendritic Cells
Open the PDF for Microtubule-Depolymerizing Agents Used in Antibody–Drug Conjugates Induce Antitumor Immunity by Stimulation of Dendritic Cells in another window
Includes: Supplementary data