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Research Article March 14 2025
CD103+CD56+ ILCs Are Associated with an Altered CD8+ T-cell Profile within the Tumor Microenvironment
Douglas C. Chung; Noor Shakfa; Jehan Vakharia; Kathrin Warner; Nicolas Jacquelot; Azin Sayad; SeongJun Han; Maryam Ghaedi; Carlos R. Garcia-Batres; Jules Sotty; Arvin Azarmina; Ferris Nowlan; Edward L.Y. Chen; Michael Zon; Alisha R. Elford; Ben X. Wang; Linh T. Nguyen; Miralem Mrkonjic; Blaise A. Clarke; Marcus Q. Bernardini; Benjamin Haibe-Kains; Sarah E. Ferguson; Sarah Q. Crome; Hartland W. Jackson; Pamela S. Ohashi
Cancer Immunol Res (2025)
In the Spotlight March 14 2025
There and back again: PD-L1 Positivity as a Biomarker for Immune Checkpoint Blockade in Urothelial Carcinoma
Cancer Immunol Res (2025)
Research Article March 13 2025
PKCδ Germline Variants and Genetic Deletion in Mice Augment Antitumor Immunity through Regulation of Myeloid Cells
Kyle R. Cron; Ayelet Sivan; Keston Aquino-Michaels; Andrea Ziblat; Emily F. Higgs; Randy F. Sweis; Ruxandra Tonea; Seoho Lee; Thomas F. Gajewski
Cancer Immunol Res (2025)
Research Article March 13 2025
Trabectedin Enhances the Antitumor Effects of IL-12 in Triple-Negative Breast Cancer
Emily Schwarz; Himanshu Savardekar; Sara Zelinskas; Abigail Mouse; Gabriella Lapurga; Justin Lyberger; Adithe Rivaldi; Emily M. Ringwalt; Katherine E. Miller; Lianbo Yu; Gregory K. Behbehani; Timothy P. Cripe; William E. Carson, III
Cancer Immunol Res (2025)
Research Article March 13 2025
Host Tissue Factors Predict Immune Surveillance and Therapeutic Outcomes in Gastric Cancer
Miseker Abate; Emily E. Stroobant; Teng Fei; Ya-Hui Lin; Shoji Shimada; Harrison Drebin; Eunise Chen; Laura H. Tang; Sohrab P. Shah; Jedd D. Wolchok; Yelena Y. Janjigian; Vivian E. Strong; Santosha A. Vardhana
Cancer Immunol Res (2025)
Research Article March 13 2025
PRDM1 Is a Key Regulator of the NKT-Cell Central Memory Program and Effector Function
Gengwen Tian; Gabriel A. Barragan; Hangjin Yu; Claudia Martinez-Amador; Akshaya Adaikkalavan; Xavier Rios; Linjie Guo; Janice M. Drabek; Osmay Pardias; Xin Xu; Antonino Montalbano; Chunchao Zhang; Yanchuan Li; Amy N. Courtney; Erica J. Di Pierro; Leonid S. Metelitsa
Cancer Immunol Res (2025)
Research Article March 12 2025
IL-15 complex enhances agonistic anti-CD40 + anti-PDL1 by correcting the T-bet to Tox ratio in CD8+ T cells infiltrating pancreatic ductal adenocarcinoma
Zoe C. Schmiechen; Hezkiel A. Nanda; Adam L. Burrack; Grant H. Hickok; Jonah Z. Butler; Eduardo Cruz-Hinojoza; Nicholas J. Maurice; Michael J. Geuenich; Chengxin Yu; Alexander K. Tsai; Cara-Lin Lonetree; Madeline A. Ellefson; Audrey L. Hilk; Brandon M. Larsen; Ebony A. Miller; Antonio B. Rizzo; Kieran R. Campbell; Steven S. Shen; Ingunn M. Stromnes
Cancer Immunol Res (2025)
Research Article March 12 2025
Lung Cancer–Intrinsic SOX2 Expression Mediates Resistance to Checkpoint Blockade Therapy by Inducing Treg‐Dependent CD8+ T-cell Exclusion
Elen Torres-Mejia; Sally Weng; Charlie A. Whittaker; Kim B. Nguyen; Ellen Duong; Leon Yim; Stefani Spranger
Cancer Immunol Res (2025)
Priority Brief March 12 2025
Different PD-L1 Assays Reveal Distinct Immunobiology and Clinical Outcomes in Urothelial Cancer
Matthew D. Galsky; Mark Kockx; Juliette Roels; Roos Van Elzen; Xiangnan Guan; Kobe Yuen; Deepali Rishipathak; Jonathan F. Anker; Sacha Gnjatic; Sudeh Izadmehr; Shomyseh Sanjabi; Robert J. Johnston; Maureen Peterson; Hartmut Koeppen; Justin M. David; Saurabh Gupta; Aristotelis Bamias; Jose Angel Arranz; Eiji Kikuchi; Maria De Santis; Ian D. Davis; Patrick Williams; Sandrine Bernhard; Ira Mellman; Enrique Grande; Romain Banchereau; Sanjeev Mariathasan
Cancer Immunol Res (2025)
Research Article March 12 2025
The Spatial Organization of cDC1 with CD8+ T Cells is Critical for the Response to Immune Checkpoint Inhibitors in Patients with Melanoma
Elisa Gobbini; Margaux Hubert; Anne-Claire Doffin; Anais Eberhardt; Léo Hermet; Danlin Li; Pierre Duplouye; Sarah Ghamry-Barrin; Justine Berthet; Valentin Benboubker; Maxime Grimont; Candice Sakref; Jimmy Perrot; Garance Tondeur; Olivier Harou; Jonathan Lopez; Bertrand Dubois; Stephane Dalle; Christophe Caux; Julie Caramel; Jenny Valladeau-Guilemond
Cancer Immunol Res (2025)
Research Article March 12 2025
In Situ Detection of Individual Classic MHC-I Gene Products in Cancer
Paula I. Gonzalez-Ericsson; Susan R. Opalenik; Violeta Sanchez; Amy M. Palubinsky; Ann Hanna; Xiaopeng Sun; Andres A. Ocampo; Guadalupe Garcia; Leonel Maldonado; Zaida Morante; Tatiana Vidaurre; Guillermo Valencia; Henry L. Gomez; Melinda E. Sanders; Laura C. Kennedy; Elizabeth J. Phillips; Justin M. Balko
Cancer Immunol Res (2025)
Research Article March 11 2025
Cytoplasmic WEE1 promotes resistance to PD-1 blockade through hyperactivation of the HSP90A/TCL1/AKT signaling axis in NANOGhigh tumors
Suyeon Kim; Hyo-Jung Lee; Seungho Lee; Jo Eun Chung; Se Jin Oh; Kwon-Ho Song; Eunho Cho; Min Kyu Son; Heeju Kwon; Seung-Jong Kim; Chaeleen Lee; Suhwan Chang; Tae Woo Kim
Cancer Immunol Res (2025)
Research Article March 11 2025
cGAS mRNA-based Immune Agonist Promotes Vaccine Responses and Antitumor Immunity
Yali Qu; Zhibin Li; Jiahao Yin; He Huang; Jialu Ma; Zhelin Jiang; Qian Zhou; Ying Tang; Yuting Li; Minpeng Huang; Zhutian Zeng; Ao Guo; Fang Fang; Yanqiong Shen; Ruibo Zhao; Yucai Wang; Daxing Gao
Cancer Immunol Res (2025)
Research Article March 11 2025
Cytotoxic chemotherapy in a 3D microfluidic device induces dendritic cell recruitment and trogocytosis of cancer cells
Cancer Immunol Res (2025)
Research Article February 26 2025
Denosumab Enhances antitumour Immunity by Suppressing SPP1 and Boosting Cytotoxic T Cells
Zezhuo Su; Maximus Chun Fai. Yeung; Shan Han; Raymond Ching Hing. Yau; Ying Lee Lam; Kenneth Wai Yip. Ho; Tony Wai. Shek; Feng Shi; Shuang Feng; Hongtai Chen; Joshua Wing Kei. Ho; ZhiYuan Xu; Jason Pui Yin. Cheung; Kelvin Sin Chi. Cheung
Cancer Immunol Res (2025)
Perspective February 25 2025
The Problem with Syngeneic Mouse Tumor Models
Cancer Immunol Res (2025)
Priority Brief February 21 2025
Inhibition of PIM kinase in tumor-associated macrophages suppresses inflammasome activation and sensitizes prostate cancer to immunotherapy
Amber N. Clements; Andrea L. Casillas; Caitlyn E. Flores; Hope Liou; Rachel K. Toth; Shailender S. Chauhan; Kai Sutterby; Sachin Kumar Deshmukh; Sharon Wu; Joanne Xiu; Alex Farrell; Milan Radovich; Chadi Nabhan; Elisabeth I. Heath; Rana R. McKay; Noor Subah; Sara Centuori; Travis J. Wheeler; Anne E. Cress; Gregory C. Rogers; Justin E. Wilson; Alejandro Recio-Boiles; Noel A. Warfel
Cancer Immunol Res (2025)
Priority Brief February 21 2025
Endogenous CD4+ T Cells That Recognize ALK and the NPM1::ALK Fusion Protein Can Be Expanded from Human Peripheral Blood
Serena Stadler; Rafael B. Blasco; Vijay Kumar Singh; Christine Damm-Welk; Amin Ben-Hamza; Carlotta Welters; Leo Hansmann; Roberto Chiarle; Wilhelm Woessmann
Cancer Immunol Res (2025)
Research Article February 14 2025
Antitumor CD4+ T helper 1 cells target and control the outgrowth of disseminated cancer cells
Ganesan Ramamoorthi; Marie Catherine. Lee; Carly M. Farrell; Colin Snyder; Saurabh K. Garg; Amy L. Aldrich; Vincent Lok; William Dominguez-Viqueira; Sy K. Olson-Mcpeek; Marilin Rosa; Namrata Gautam; Shari Pilon-Thomas; Ling Cen; Krithika N. Kodumudi; Doris Wiener; Thordur Oskarsson; Ana P. Gomes; Robert A. Gatenby; Brian J. Czerniecki
Cancer Immunol Res (2025)
Research Article February 12 2025
PTP inhibition improves the macrophage anti-tumor immune response and the efficacy of chemo- and radiotherapy
Nestor Prieto-Dominguez; Paran Goel; Oluwagbemiga A. Ojo; Katarina Moretto; Alisha Holtzhausen; Angel Humphryes; Xinyue Zhou; Valeriya Kuznetsova; Francesca Dempsey; Kelly Pittman; Rui Lu; Todd J. Green; Lewis Z. Shi; Robert S. Welner; H. Shelton Earp; Eric Ubil
Cancer Immunol Res (2025)
Research Article February 11 2025
TLR5 signaling causes dendritic-cell dysfunction and orchestrates failure of immune checkpoint therapy against ovarian cancer
Mitchell T. McGinty; Audrey M. Putelo; Sree H. Kolli; Tzu-Yu Feng; Madison R. Dietl; Cara N. Hatzinger; Simona Bajgai; Mika K. Poblete; Francesca N. Azar; Anwaruddin Mohammad; Pankaj Kumar; Melanie R. Rutkowski
Cancer Immunol Res (2025)
Research Article February 7 2025
Selective STING Activation in Intratumoral Myeloid Cells via CCR2-Directed Antibody Drug Conjugate TAK-500
Vicky A. Appleman; Atsushi Matsuda; Michelle L. Ganno; Dong Mei Zhang; Emily Rosentrater; Angel E. Maldonado Lopez; Angelo Porciuncula; Tiquella Hatten; Camilla L. Christensen; Samantha A. Merrigan; Hong Myung Lee; Min Young Lee; Charlotte I. Wang; Linlin Dong; Jian Huang; Natasha Iartchouk; Jianing Wang; He Xu; Tomoki Yoneyama; Konstantin I. Piatkov; Satyajeet Haridas; Carole E. Harbison; Richard C. Gregory; Alexander Parent; Neil Lineberry; Chris Arendt; Kurt A. Schalper; Adnan O. Abu-Yousif
Cancer Immunol Res (2025)
Research Article January 31 2025
Tertiary lymphoid structures are associated with enhanced macrophage activation and immune checkpoint expression, and predict outcome in cervical cancer
Laurent Gorvel; Marylou Panouillot; Marie-Sarah Rouvière; Emilien Billon; Stéphane Fattori; Jumaporn Sonongbua; Nicolas Boucherit; Amira Ben Amara; Olivia Quilichini; Samuel Granjeaud; Clara Degos; Jacques A. Nunès; Xavier Carcopino; Eric Lambaudie; Anne-Sophie Chrétien; Renaud Sabatier; Marie-Caroline Dieu-Nosjean; Daniel Olive
Cancer Immunol Res (2025)
Research Article January 29 2025
A bifunctional antibody targeting PD-1 and TGF-β signaling has antitumor activity in combination with radiotherapy and attenuates radiation-induced lung injury
Sheng Wang; Duo Xu; Yuan Wang; Yuehua Zhou; Lingyan Xiao; Fang Li; Jingyao Tu; Wan Qin; Sidan Tian; Bolong Zheng; Yihua Wang; Xiang-lin Yuan; Yuanhui Liu; Bo Liu
Cancer Immunol Res (2025)
Review January 29 2025
The Bidirectional Interplay between T Cell–Based Immunotherapies and the Tumor Microenvironment
Cancer Immunol Res (2025)
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