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Research Article May 25 2023
Small gene networks delineate immune cell states and characterize immunotherapy response in melanoma
Donagh Egan; Martina Kreileder; Myriam Nabhan; Luis F. Iglesias-Martinez; Simon J. Dovedi; Viia Valge-Archer; Amit Grover; Robert W. Wilkinson; Timothy Slidel; Claus Bendtsen; Ian P. Barrett; Donal J. Brennan; Walter Kolch; Vadim Zhernovkov
Cancer Immunol Res CIR-22-0563.
Research Article May 25 2023
Systemic Alterations in Type-2 Conventional Dendritic Cells Leads to Impaired Tumor Immunity in Pancreatic Cancer
C. Alston. James; John M. Baer; Chong Zuo; Usman Y. Panni; Brett L. Knolhoff; Graham D. Hogg; Natalie L. Kingston; Liang-I Kang; Varintra E. Lander; Jingqin Luo; Yu Tao; Mark A. Watson; Rebecca Aft; Ryan C. Fields; William G. Hawkins; David G. DeNardo
Cancer Immunol Res CIR-21-0946.
Priority Brief May 22 2023
T cell–mediated development of stromal fibroblasts with an immune-enhancing chemokine profile
Cancer Immunol Res CIR-22-0593.
Research Article May 22 2023
CD69 imposes tumor-specific CD8+ T-cell fate in tumor-draining lymph nodes
Ryo Koyama-Nasu; Motoko Y. Kimura; Masahiro Kiuchi; Ami Aoki; Yangsong Wang; Yukiyoshi Mita; Ichita Hasegawa; Yukihiro Endo; Atsushi Onodera; Kiyoshi Hirahara; Shinichiro Motohashi; Toshinori Nakayama
Cancer Immunol Res CIR-22-0406.
Research Article May 18 2023
MYC Induces Immunotherapy and IFNγ Resistance Through Downregulation of JAK2
Ettai Markovits; Ortal Harush; Erez N. Baruch; Eldad D. Shulman; Assaf Debby; Orit Itzhaki; Liat Anafi; Artem Danilevsky; Noam Shomron; Guy Ben-Betzalel; Nethanel Asher; Ronnie Shapira-Frommer; Jacob Schachter; Iris Barshack; Tamar Geiger; Ran Elkon; Michal J. Besser; Gal Markel
Cancer Immunol Res (2023)
Research Article May 18 2023
mWTX-330, an IL-12 INDUKINE Molecule, Activates and Reshapes Tumor-Infiltrating CD8+ T and NK Cells to Generate Antitumor Immunity
Christopher J. Nirschl; Heather R. Brodkin; Celesztina Domonkos; Connor J. Dwyer; Daniel J. Hicklin; Nesreen Ismail; Cynthia Seidel-Dugan; Philipp Steiner; Zoe Steuert; Jenna M. Sullivan; William M. Winston; Andres Salmeron
Cancer Immunol Res (2023)
Research Article May 18 2023
IL12/18/21 Preactivation Enhances the Antitumor Efficacy of Expanded γδT Cells and Overcomes Resistance to Anti–PD-L1 Treatment
Huey Yee Teo; Yuan Song; Kylie Su Mei Yong; Yonghao Liu; Yu Mei; Zuhairah Binte Hanafi; Ying Zhu; Yen Leong Chua; Nicholas R.J. Gascoigne; Qingfeng Chen; Haiyan Liu
Cancer Immunol Res (2023)
Research Article May 12 2023
Feasibility and Safety of Personalized, Multi-Target, Adoptive Cell Therapy (IMA101): First-In-Human Clinical Trial in Patients with Advanced Metastatic Cancer
Apostolia M. Tsimberidou; Kerstin Guenther; Borje S. Andersson; Regina Mendrzyk; Amir Alpert; Claudia Wagner; Anna Nowak; Katrin Aslan; Arun Satelli; Fabian Richter; Sabrina Kuttruff-Coqui; Oliver Schoor; Jens Fritsche; Zoe Coughlin; Ali S. Mohamed; Kerry Sieger; Becky Norris; Rita Ort; Jennifer Beck; Henry Hiep. Vo; Franziska Hoffgaard; Manuel Ruh; Linus Backert; Ignacio I. Wistuba; David Fuhrmann; Nuhad K. Ibrahim; Van Karlyle. Morris; Bryan K. Kee; Daniel M. Halperin; Graciela M. Nogueras-González; Partow Kebriaei; Elizabeth J. Shpall; David Vining; Patrick Hwu; Harpreet Singh-Jasuja; Carsten Reinhardt; Cedrik M. Britten; Norbert Hilf; Toni Weinschenk; Dominik Maurer; Steffen Walter
Cancer Immunol Res CIR-22-0444.
Research Article May 12 2023
Targeting the IL1β Pathway for Cancer Immunotherapy Remodels the Tumor Microenvironment and Enhances Antitumor Immune Responses
Rohan Diwanji; Neil A. O'Brien; Jiyoung E. Choi; Beverly Nguyen; Tyler Laszewski; Angelo L. Grauel; Zheng Yan; Xin Xu; Jincheng Wu; David A. Ruddy; Michelle Piquet; Marc R. Pelletier; Alexander Savchenko; LaSalette Charette; Vanessa Rodrik-Outmezguine; Jason Baum; John M. Millholland; Connie C. Wong; Anne-Marie Martin; Glenn Dranoff; Iulian Pruteanu-Malinici; Viviana Cremasco; Catherine Sabatos-Peyton; Pushpa Jayaraman
Cancer Immunol Res (2023)
Research Article May 12 2023
iBRIDGE: A Data Integration Method to Identify Inflamed Tumors from Single-cell RNA-Seq Data and Differentiate Cell Type–Specific Markers of Immune-Cell Infiltration
Tolga Turan; Sarah Kongpachith; Kyle Halliwill; Robert T. McLaughlin; Mikhail Binnewies; Dhemath Reddy; Xi Zhao; Rebecca Mathew; Shiming Ye; Howard J. Jacob; Josue Samayoa
Cancer Immunol Res (2023)
In the Spotlight May 12 2023
Ethnicity, Immunity, and Outcomes: Biology versus Socioeconomic Status
Cancer Immunol Res (2023)
Research Article May 10 2023
Single-Cell Profiling of CD8+ T Cells in Acute Myeloid Leukemia Reveals a Continuous Spectrum of Differentiation and Clonal Hyperexpansion
Poonam N. Desai; Bofei Wang; Andre Fonseca; Pamella Borges; Fatima Zahra. Jelloul; Patrick K. Reville; Eric Lee; Christopher Ly; Akshay Basi; Jessica Root; Natalia Baran; Sean M. Post; Qing Deng; Hanxiao Sun; Arif O. Harmanci; Jared K. Burks; Javier A. Gomez; Courtney D. DiNardo; Naval G. Daver; Gheath Alatrash; Marina Konopleva; Michael R. Green; Dinler A. Antunes; Andrew Futreal; Dapeng Hao; Hussein A. Abbas
Cancer Immunol Res CIR-22-0961.
Research Article May 5 2023
Influence of Adipose Tissue Distribution, Sarcopenia, and Nutritional Status on Clinical Outcomes After CD19 CAR T-cell Therapy
Kai Rejeski; David M. Cordas dos Santos; Nathan H. Parker; Veit L. Bücklein; Michael Winkelmann; Khushali S. Jhaveri; Lian Liu; Paul Trinkner; Sophie Günther; Philipp Karschnia; Viktoria Blumenberg; Christian Schmidt; Wolfgang G. Kunz; Michael von Bergwelt-Baildon; Michael D. Jain; Sebastian Theurich; Marion Subklewe
Cancer Immunol Res (2023)
In the Spotlight May 5 2023
Linking Body Composition and Nutritional Status with CAR T-cell Efficacy
Cancer Immunol Res (2023)
Research Article May 4 2023
Breast Cancer Stem Cell–Derived Tumors Escape from γδ T-cell Immunosurveillance In Vivo by Modulating γδ T-cell Ligands
Katrin Raute; Juliane Strietz; Maria Alejandra Parigiani; Geoffroy Andrieux; Oliver S. Thomas; Klaus M. Kistner; Marina Zintchenko; Peter Aichele; Maike Hofmann; Houjiang Zhou; Wilfried Weber; Melanie Boerries; Mahima Swamy; Jochen Maurer; Susana Minguet
Cancer Immunol Res (2023)
Research Article May 2 2023
KRT17 promotes T-lymphocyte infiltration through the YTHDF2-CXCL10 axis in colorectal cancer
Wenfeng Liang; Huashan Liu; Ziwei Zeng; Zhenxing Liang; Hao Xie; Wenxin Li; Li Xiong; Zhihang Liu; Mian Chen; Haiqing Jie; Xiaobin Zheng; Liang Huang; Liang Kang
Cancer Immunol Res CIR-22-0814.
Research Article May 2 2023
NL-201 upregulates MHC-I expression and intratumoral TCR diversity, and demonstrates robust antitumor activity as monotherapy and in combination with PD-1 blockade
Cancer Immunol Res CIR-22-0304.
Research Article May 2 2023
The Immunopeptidome from a Genomic Perspective: Establishing the Noncanonical Landscape of MHC Class I–Associated Peptides
Georges Bedran; Hans-Christof Gasser; Kenneth Weke; Tongjie Wang; Dominika Bedran; Alexander Laird; Christophe Battail; Fabio Massimo Zanzotto; Catia Pesquita; Håkan Axelson; Ajitha Rajan; David J. Harrison; Aleksander Palkowski; Maciej Pawlik; Maciej Parys; J. Robert O'Neill; Paul M. Brennan; Stefan N. Symeonides; David R. Goodlett; Kevin Litchfield; Robin Fahraeus; Ted R. Hupp; Sachin Kote; Javier A. Alfaro
Cancer Immunol Res (2023)
Research Article May 2 2023
Clonal Spreading of Tumor-Infiltrating T Cells Underlies the Robust Antitumor Immune Responses
Hiroyasu Aoki; Mikiya Tsunoda; Haru Ogiwara; Haruka Shimizu; Haruka Abe; Tatsuro Ogawa; Takaya Abe; Shigeyuki Shichino; Kouji Matsushima; Satoshi Ueha
Cancer Immunol Res (2023)
Research Article April 27 2023
EBV-Upregulated B7-H3 Inhibits NK cell–Mediated Antitumor Function and Contributes to Nasopharyngeal Carcinoma Progression
Haiwen Chen; Xiaobing Duan; Xiaohong Deng; Yingping Huang; Xiang Zhou; Shanshan Zhang; Xiao Zhang; Pingjuan Liu; Chaopin Yang; Guojun Liu; Qinqin Ren; Yan Xiong; Bo Zhu; Jiexia Zhang; Tong Xiang
Cancer Immunol Res (2023)
Research Article April 27 2023
Anti–PD-1 and Extended Half-life IL2 Synergize for Treatment of Murine Glioblastoma Independent of Host MHC Class I Expression
Zachariah P. Tritz; Katayoun Ayasoufi; Delaney M. Wolf; Carley A. Owens; Courtney S. Malo; Benjamin T. Himes; Cori E. Fain; Emma N. Goddery; Lila T. Yokanovich; Fang Jin; Michael J. Hansen; Ian F. Parney; Chensu Wang; Kelly D. Moynihan; Darrell J. Irvine; K. Dane Wittrup; Rosa M. Diaz Marcano; Richard G. Vile; Aaron J. Johnson
Cancer Immunol Res (2023)
Research Article April 18 2023
T Cells Expressing a Modified FcγRI Exert Antibody-Dependent Cytotoxicity and Overcome the Limitations of CAR T-cell Therapy against Solid Tumors
Diana Rasoulouniriana; Nadine Santana-Magal; Amit Gutwillig; Leen Farhat-Younis; Lior Tal; Sarah Amar; Michael Milyavsky; Siva Sai Naga Anurag Muddineni; Neta Solomon; Hana Shpilt; Shahar Dotan; Noam Pilpel; Claudia Waskow; Meora Feinmesser; Peleg Rider; Yaron Carmi
Cancer Immunol Res (2023)
Research Article April 16 2023
High Expression of MHC Class I Overcomes Cancer Immunotherapy Resistance Due to IFNγ Signaling Pathway Defects
Katsushige Kawase; Shusuke Kawashima; Joji Nagasaki; Takashi Inozume; Etsuko Tanji; Masahito Kawazu; Toyoyuki Hanazawa; Yosuke Togashi
Cancer Immunol Res (2023)
Research Article April 14 2023
Regional variation in the tumor microenvironment, immune escape and prognostic factors in breast cancer in sub-Saharan Africa
Marcus Bauer; Martina Vetter; Kathrin Stückrath; Meron Yohannes; Zelalem Desalegn; Tewodros Yalew; Yonas Bekuretsion; Tariku W. Kenea; Maureen Joffe; Eunice J. Van Den Berg; Julien Ilunga. Nikulu; Kamaté Bakarou; Shyam S. Manraj; Olufemi J. Ogunbiyi; Ima-Obong Ekanem; Festus Igbinoba; Mohenou Diomande; Clement Adebamowo; Charles P. Dzamalala; Angelica A. Anele; Annelle Zietsman; Moses Galukande; Milena Foerster; Isabel dos-Santos-Silva; Biying Liu; Pablo Santos; Ahmedin Jemal; Tamrat Abebe; Claudia Wickenhauser; Barbara Seliger; Valerie McCormack; Eva J. Kantelhardt
Cancer Immunol Res CIR-22-0795.
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