Issues
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Cover Image
Cover Image
The identity and frequency of immune cells in the tumor microenvironment impact outcomes for patients with colorectal cancer. Using single-cell RNA sequencing data, Foroutan et al. identify signatures of residency and exhaustion for tumor-infiltrating CD8+, CD4+, and natural killer (NK) cells. Different signature combinations associated with distinct patient outcomes; for example, signatures of high NK-cell exhaustion and low NK-cell residency were associated with improved survival. The data provide new insight into the characteristics of tumor-infiltrating lymphocytes and suggest that preventing tumor residency by NK cells may enhance antitumor immunity and patient outcomes. Read more in this issue on page 1125. Artwork by Momeneh Foroutan inspired by several figures in the article, including the CD8 residency panel of Fig. 1B, shown here. - PDF Icon PDF LinkTable of Contents
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Cancer Immunology Research
Cancer Immunology Research, launched in 2013 with Glenn Dranoff as founding Editor-in-Chief, is published by the AACR. The Journal illuminates the interplay between tumors and the immune system, with Robert D. Schreiber and Philip D. Greenberg serving as the Editors-in-Chief.
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What We’re Reading
In the Spotlight
Research Articles
An Engineered IL15 Cytokine Mutein Fused to an Anti-PD1 Improves Intratumoral T-cell Function and Antitumor Immunity
Bispecific CAR T Cells against EpCAM and Inducible ICAM-1 Overcome Antigen Heterogeneity and Generate Superior Antitumor Responses
Combining an Alarmin HMGN1 Peptide with PD-L1 Blockade Results in Robust Antitumor Effects with a Concomitant Increase of Stem-Like/Progenitor Exhausted CD8+ T Cells
Research Article
TMB and Inflammatory Gene Expression Associated with Clinical Outcomes following Immunotherapy in Advanced Melanoma
Journal Archive
Cancer Immunology Research
(2013-Present)Published monthly since 2013.
(ISSN 2326-6066)
Cancer Immunity
(2001-2013; volumes 1-13)Published periodically from 2001-2013.
(EISSN 1424-9634)
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