Issues
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Cover Image
Cover Image
The prognostic value of tumor-associated macrophages (TAM) remains to be fully elucidated. By combining multiplex immunofluorescence with digital analysis and machine learning, Väyrynen et al. show that TAM subsets have distinct prognostic roles in patients with colorectal cancer. Total intraepithelial and stromal TAM densities are not prognostic. Rather, TAM polarization is key, with M2-like TAMs correlating with worse cancer-specific survival. Interestingly, a survival benefit is not seen when assessing M1-like TAMs in the tumor stromal region, although high M1:M2 density ratio is associated with better survival. The study highlights the importance of utilizing multiplex analysis to more accurately determine the prognostic value of immune-cell subsets, as total population assessment or single-marker analysis may mask underlying associations. Read more in this issue on page 8. Original image from Supplementary Fig. S3B. Artwork by Lewis Long. - PDF Icon PDF LinkTable of Contents
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Cancer Immunology Research
Cancer Immunology Research, launched in 2013 with Glenn Dranoff as founding Editor-in-Chief, is published by the AACR. The Journal illuminates the interplay between tumors and the immune system, with Robert D. Schreiber and Philip D. Greenberg serving as the Editors-in-Chief.
Table of Contents
What We’re Reading
Cancer Immunology at the Crossroads
Research Articles
The Prognostic Role of Macrophage Polarization in the Colorectal Cancer Microenvironment
A CRISPR Screen Reveals Resistance Mechanisms to CD3-Bispecific Antibody Therapy
A Bispecific Antibody Antagonizes Prosurvival CD40 Signaling and Promotes Vγ9Vδ2 T cell–Mediated Antitumor Responses in Human B-cell Malignancies
CD28 Costimulatory Domain–Targeted Mutations Enhance Chimeric Antigen Receptor T-cell Function
The Cerebroventricular Environment Modifies CAR T Cells for Potent Activity against Both Central Nervous System and Systemic Lymphoma
Acknowledgment to Reviewers
Journal Archive
Cancer Immunology Research
(2013-Present)Published monthly since 2013.
(ISSN 2326-6066)
Cancer Immunity
(2001-2013; volumes 1-13)Published periodically from 2001-2013.
(EISSN 1424-9634)
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