Lymph node composition and structure contribute to the induction of antitumor T-cell responses. A better understanding of how melanoma metastasizing to the lymph node can alter stromal cell phenotype and function and, thus, suppressing antitumor immune responses may improve treatment. Here, the Dunbar laboratory and colleagues define two distinct subsets of stromal cells in metastatic lymph nodes: one is similar to fibroblastic reticular cells and may inhibit T cells, and another supports extracellular matrix production. Molecular profiles of these populations differ from those of stromal cell populations in normal lymph nodes. The phenotypic markers that define the two stromal subsets within tumor-infiltrated lymph nodes could aid in producing new therapeutic strategies to enhance antitumor immunity. To read more, Eom and Park et al. begins on page 990. Immunofluorescence staining from the Dunbar laboratory. Artwork by Lewis Long.