Issues
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Cover Image
Cover Image
Evidence for bispecific antibody efficacy against solid tumors is limited, and additional approaches may be required in the clinic to achieve the success seen with hematologic tumors. Chiu et al. address this by designing a CD3 bispecific antibody that also targets a major prostate cancer tumor antigen, prostate-specific membrane antigen (PSMA). Preclinical models show positive responses to bispecific antibody treatment that is dependent on tumor size, with smaller tumors being more sensitive than larger tumors. However, by combining the bispecific antibody with 4-1BB costimulation, larger tumors are more readily reduced due to boosted, durable T-cell responses and the generation of immune memory. The data highlight that tumor size matters and that 4-1BB costimulation can be used to increase the potency of bispecific antibody treatment in solid tumors. Read more in this issue on page 596. Original image from Supplementary Fig. S5A. Artwork by Lewis Long. - PDF Icon PDF LinkTable of Contents
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Cancer Immunology Research
Cancer Immunology Research, launched in 2013 with Glenn Dranoff as founding Editor-in-Chief, is published by the AACR. The Journal illuminates the interplay between tumors and the immune system, with Robert D. Schreiber and Philip D. Greenberg serving as the Editors-in-Chief.
Table of Contents
What We’re Reading
Cancer Immunology Miniatures
Priority Brief
Research Articles
A PSMA-Targeting CD3 Bispecific Antibody Induces Antitumor Responses that Are Enhanced by 4-1BB Costimulation
Single-Cell Immune Competency Signatures Associate with Survival in Phase II GVAX and CRS-207 Randomized Studies in Patients with Metastatic Pancreatic Cancer
Intratumoral Delivery of a PD-1–Blocking scFv Encoded in Oncolytic HSV-1 Promotes Antitumor Immunity and Synergizes with TIGIT Blockade
Prevalent and Diverse Intratumoral Oncoprotein-Specific CD8+ T Cells within Polyomavirus-Driven Merkel Cell Carcinomas
IL1α Antagonizes IL1β and Promotes Adaptive Immune Rejection of Malignant Tumors
Identification of the Targets of T-cell Receptor Therapeutic Agents and Cells by Use of a High-Throughput Genetic Platform
Enhanced Immunogenicity of Mitochondrial-Localized Proteins in Cancer Cells
RIPK3 Orchestrates Fatty Acid Metabolism in Tumor-Associated Macrophages and Hepatocarcinogenesis
Journal Archive
Cancer Immunology Research
(2013-Present)Published monthly since 2013.
(ISSN 2326-6066)
Cancer Immunity
(2001-2013; volumes 1-13)Published periodically from 2001-2013.
(EISSN 1424-9634)
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