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1 November 2020
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Although immune checkpoint blockade (ICB) has shown success in prolonging the survival of patients with cancer, the mechanisms behind this are not fully elucidated. Chen et al. find that tumor-derived IL33, whose expression increases after ICB treatment, and ST2 signaling in nontumor cells are key to inducing antitumor responses. IL33 increases functional CD103+CD8+ T cells and CD103+ dendritic cells (DC) in the tumor microenvironment (TME), and the CD103+ DCs are essential for the recruitment of tumor-infiltrating CD8+ T cells into the TME. By treating tumor-bearing mice with IL33 in combination with dual ICB, survival was extended, highlighting the important role of IL33 in mediating the efficacy of ICB. Read more in this issue on page 1381. Original image from Fig. 4F. Artwork by Lewis Long.Close Modal - PDF Icon PDF LinkTable of Contents
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ISSN 2326-6066
EISSN 2326-6074
Journal Archive
Cancer Immunology Research (2013-Present)
(ISSN 2326-6066) Published monthly since 2013.Cancer Immunity (2001-2013; volumes 1-13)
(EISSN 1424-9634) Published periodically from 2001-2013.Table of Contents
What We’re Reading
Editorial
Cancer Immunology at the Crossroads
Cancer Immunology Miniatures
Tumor Mutation Burden and Structural Chromosomal Aberrations Are Not Associated with T-cell Density or Patient Survival in Acral, Mucosal, and Cutaneous Melanomas
Jarem Edwards; Peter M. Ferguson; Serigne N. Lo; Inês Pires da Silva; Andrew J. Colebatch; Hansol Lee; Robyn P.M. Saw; John F. Thompson; Alexander M. Menzies; Georgina V. Long; Felicity Newell; John V. Pearson; Nicola Waddell; Nicholas K. Hayward; Peter A. Johansson; Graham J. Mann; Richard A. Scolyer; Umaimainthan Palendira; James S. Wilmott
Priority Brief
A DNA-Launched Nanoparticle Vaccine Elicits CD8+ T-cell Immunity to Promote In Vivo Tumor Control
Ziyang Xu; Neethu Chokkalingam; Edgar Tello-Ruiz; Megan C. Wise; Mamadou A. Bah; Susanne Walker; Nicholas J. Tursi; Paul D. Fisher; Katherine Schultheis; Kate E. Broderick; Laurent Humeau; Daniel W. Kulp; David B. Weiner
Research Articles
Melanoma Evolves Complete Immunotherapy Resistance through the Acquisition of a Hypermetabolic Phenotype
Ashvin R. Jaiswal; Arthur J. Liu; Shivanand Pudakalakatti; Prasanta Dutta; Priyamvada Jayaprakash; Todd Bartkowiak; Casey R. Ager; Zhi-Qiang Wang; Alexandre Reuben; Zachary A. Cooper; Cristina Ivan; Zhenlin Ju; Felix Nwajei; Jing Wang; Michael A. Davies; R. Eric Davis; Jennifer A. Wargo; Pratip K. Bhattacharya; David S. Hong; Michael A. Curran
Tumor-Infiltrating Regulatory T-cell Accumulation in the Tumor Microenvironment Is Mediated by IL33/ST2 Signaling
Jimin Son; Jae-Won Cho; Hyo Jin Park; Jihyun Moon; Seyeon Park; Hoyoung Lee; Jeewon Lee; Gamin Kim; Su-Myeong Park; Sergio A. Lira; Andrew N. Mckenzie; Hye Young Kim; Cheol Yong Choi; Yong Taik Lim; Seong Yong Park; Hye Ryun Kim; Su-Hyung Park; Eui-Cheol Shin; Insuk Lee; Sang-Jun Ha
Glycans as Immune Checkpoints: Removal of Branched N-glycans Enhances Immune Recognition Preventing Cancer Progression
Mariana C. Silva; Ângela Fernandes; Maria Oliveira; Carlos Resende; Alexandra Correia; Julio C. de-Freitas-Junior; Aonghus Lavelle; Jéssica Andrade-da-Costa; Magdalena Leander; Helena Xavier-Ferreira; José Bessa; Carina Pereira; Rui M. Henrique; Fátima Carneiro; Mário Dinis-Ribeiro; Ricardo Marcos-Pinto; Margarida Lima; Bernd Lepenies; Harry Sokol; José C. Machado; Manuel Vilanova; Salomé S. Pinho
Infiltration by IL22-Producing T Cells Promotes Neutrophil Recruitment and Predicts Favorable Clinical Outcome in Human Colorectal Cancer
Nadia Tosti; Eleonora Cremonesi; Valeria Governa; Camilla Basso; Venkatesh Kancherla; Mairene Coto-Llerena; Francesca Amicarella; Benjamin Weixler; Silvio Däster; Giuseppe Sconocchia; Pietro Edoardo Majno; Dimitri Christoforidis; Luigi Tornillo; Luigi Terracciano; Charlotte K.Y. Ng; Salvatore Piscuoglio; Markus von Flüe; Giulio Spagnoli; Serenella Eppenberger-Castori; Giandomenica Iezzi; Raoul Andre Droeser
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