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1 April 2019
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CD96 is an immune checkpoint and is known to suppress T-cell and NK cell effector functions. Thus, CD96 can impair antitumor responses in the tumor microenvironment. Mittal et al. demonstrate that CD96 blockade can inhibit primary tumor growth in multiple tumor models. The effects of anti-CD96 are dependent on several host factors, including CD8+ T cells, cytokines, and DNAM-1/CD226 signaling. Because CD96 is co-expressed with other immune checkpoints, especially PD-1, dual and triple blockade protocols were tested. Dual blockade of CD96 and other immune checkpoints is more effective than anti-CD96 monotherapy, and an optimal triple combination blocking CD96, PD-1, and TIGIT is superior over dual combinations. These treatments increase T-cell infiltration and enhance antitumor responses, highlighting that combining the targeting of CD96 with other immune checkpoints could be a strategy for augmenting T-cell responses that suppress tumor growth. Read more in this issue on page 559. Original image from Fig. 3A. Artwork by Lewis Long. - PDF Icon PDF LinkTable of Contents
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ISSN 2326-6066
EISSN 2326-6074
Journal Archive
Cancer Immunology Research (2013-Present)
(ISSN 2326-6066) Published monthly since 2013.Cancer Immunity (2001-2013; volumes 1-13)
(EISSN 1424-9634) Published periodically from 2001-2013.Table of Contents
What We’re Reading
Cancer Immunology at the Crossroads
Cancer Immunology Miniature
Immunologic Recognition of a Shared p53 Mutated Neoantigen in a Patient with Metastatic Colorectal Cancer
Winifred Lo; Maria Parkhurst; Paul F. Robbins; Eric Tran; Yong-Chen Lu; Li Jia; Jared J. Gartner; Anna Pasetto; Drew Deniger; Parisa Malekzadeh; Thomas E. Shelton; Todd Prickett; Satyajit Ray; Scott Kivitz; Biman C. Paria; Isaac Kriley; David S. Schrump; Steven A. Rosenberg
Priority Briefs
Early-Life Microbiota Exposure Restricts Myeloid-Derived Suppressor Cell–Driven Colonic Tumorigenesis
Akihito Harusato; Emilie Viennois; Lucie Etienne-Mesmin; Shingo Matsuyama; Hirohito Abo; Satoru Osuka; Nicholas W. Lukacs; Yuji Naito; Yoshito Itoh; Jian-Dong Li; Didier Merlin; Andrew T. Gewirtz; Timothy L. Denning
Broad Cytotoxic Targeting of Acute Myeloid Leukemia by Polyclonal Delta One T Cells
Biagio Di Lorenzo; André E. Simões; Francisco Caiado; Paola Tieppo; Daniel V. Correia; Tânia Carvalho; Maria Gomes da Silva; Julie Déchanet-Merville; Ton N. Schumacher; Immo Prinz; Haakan Norell; Sarina Ravens; David Vermijlen; Bruno Silva-Santos
Research Articles
CD96 Is an Immune Checkpoint That Regulates CD8+ T-cell Antitumor Function
Deepak Mittal; Ailin Lepletier; Jason Madore; Amelia Roman Aguilera; Kimberley Stannard; Stephen J. Blake; Vicki L.J. Whitehall; Cheng Liu; Mark L. Bettington; Kazuyoshi Takeda; Georgina V. Long; Richard A. Scolyer; Ruth Lan; Nathan Siemers; Alan Korman; Michele W.L. Teng; Robert J. Johnston; William C. Dougall; Mark J. Smyth
Intravesical Ty21a Vaccine Promotes Dendritic Cells and T Cell–Mediated Tumor Regression in the MB49 Bladder Cancer Model
Sonia Domingos-Pereira; Karthik Sathiyanadan; Stefano La Rosa; Lenka Polák; Mathieu F. Chevalier; Paul Martel; Rim Hojeij; Laurent Derré; Jacques-Antoine Haefliger; Patrice Jichlinski; Denise Nardelli-Haefliger
Low-Dose Apatinib Optimizes Tumor Microenvironment and Potentiates Antitumor Effect of PD-1/PD-L1 Blockade in Lung Cancer
Sha Zhao; Shengxiang Ren; Tao Jiang; Bo Zhu; Xuefei Li; Chao Zhao; Yijun Jia; Jinpeng Shi; Limin Zhang; Xiaozhen Liu; Meng Qiao; Xiaoxia Chen; Chunxia Su; Hui Yu; Caicun Zhou; Jun Zhang; D. Ross Camidge; Fred R. Hirsch
Immune Profiling and Quantitative Analysis Decipher the Clinical Role of Immune-Checkpoint Expression in the Tumor Immune Microenvironment of DLBCL
Ziju Y. Xu-Monette; Min Xiao; Qingyan Au; Raghav Padmanabhan; Bing Xu; Nicholas Hoe; Sandra Rodríguez-Perales; Raul Torres-Ruiz; Ganiraju C. Manyam; Carlo Visco; Yi Miao; Xiaohong Tan; Hongwei Zhang; Alexandar Tzankov; Jing Wang; Karen Dybkær; Wayne Tam; Hua You; Govind Bhagat; Eric D. Hsi; Maurilio Ponzoni; Andrés J.M. Ferreri; Michael B. Møller; Miguel A. Piris; J. Han van Krieken; Jane N. Winter; Jason R. Westin; Lan V. Pham; L. Jeffrey Medeiros; George Z. Rassidakis; Yong Li; Gordon J. Freeman; Ken H. Young
Autologous Lymphocyte Infusion Supports Tumor Antigen Vaccine–Induced Immunity in Autologous Stem Cell Transplant for Multiple Myeloma
Adam D. Cohen; Nikoletta Lendvai; Sarah Nataraj; Naoko Imai; Achim A. Jungbluth; Ioanna Tsakos; Adeeb Rahman; Anna Huo-Chang Mei; Herman Singh; Katarzyna Zarychta; Seunghee Kim-Schulze; Andrew Park; Ralph Venhaus; Katherine Alpaugh; Sacha Gnjatic; Hearn J. Cho
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