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Chemokine and chemotactic receptor expression in nonhematopoietic cells can affect tumor formation, in part by altering the influx of innate immune cells into the tumor microenvironment (TME). Del Prete et al. investigate the link between mouse atypical chemotactic receptor CCRL2 expression in lung endothelial cells with immune surveillance of lung cancer and subsequent tumor formation. Knockout of CCRL2 in mice or antibody blockade of CCRL2 increases the establishment of lung cancer lesions, leading to poorer mouse survival, by inhibiting NK cell migration into the TME. CCRL2 expression is lower in patient lung tumor tissue compared to paired normal lung tissue, with low tumoral CCRL2 expression correlating to poorer patient survival. Read more starting on page 1775. Artwork is based on Figure 6D by the Sozzani laboratory. Artwork by Lewis Long.