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Tissue and tumor vasculature needs to express appropriate “homing receptor ligands” to mediate the entry of T cells expressing “homing receptors” on their surfaces. The Engelhard laboratory investigated which homing receptors and tumor-expressed ligands are required for T-cell infiltration into tumors residing in different tissues. The tumor vasculature responded to the IFNγ. produced by activated T cells, upregulating particular ligands that allowed the accumulation of T cells expressing the appropriate homing receptors. The altered expression of their homing receptors on T cells, based on site of activation, creates a receptor-ligand recognition system that may be exploitable for clinical practice. Read more in Woods et al. in this issue of Cancer Immunology Research, starting on p. 1062. Fluorescence micrograph of an intraperitoneal tumor from Fig. 5C, with green depicting the vasculature. Artwork by Lewis Long.