Highlights from the Literature
Extracellular S100A9 Protein in Bone Marrow Supports Multiple Myeloma Survival by Stimulating Angiogenesis and Cytokine Secretion
Antigen-Presenting Intratumoral B Cells Affect CD4+ TIL Phenotypes in Non–Small Cell Lung Cancer Patients
The Antitumor Effects of Vaccine-Activated CD8+ T Cells Associate with Weak TCR Signaling and Induction of Stem-Like Memory T Cells
Vaccine-activated CD8+ T cells that had weaker TCR signaling had stronger antitumor effects. Weak activation halted differentiation at the stem-like memory T-cell stage, generating more Tscm cells, and protected T effectors from antigen-induced exhaustion and apoptosis.