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1 October 2017
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About the Cover
Human papilloma virus (HPV) is associated with several malignancies, especially cervical and head and neck cancers. Vaccines are being used to treat various cancers, but with limited success. Atherton et al. demonstrate a promising approach that may provide more consistent antitumor responses. They infected mice with the oncolytic Maraba virus, which selectively infects and lyses tumor cells, while also acting as a vaccine, based on attenuated HPV E6 and E7 transforming proteins. Antigen-specific CD8+ T cells were activated, HPV+ tumors eradicated, and memory induced. This one-two punch strategy may overcome the immunosuppression of advanced disease. Read more in this issue starting on page 847. The micrograph is a hematoxylin-eosin stain of a TC1 tumor harvested from a vaccine-treated mouse. Artwork by Lewis Long. - PDF Icon PDF LinkTable of Contents
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ISSN 2326-6066
EISSN 2326-6074
Issue Sections
Journal Archive
Cancer Immunology Research (2013-Present)
(ISSN 2326-6066) Published monthly since 2013.Cancer Immunity (2001-2013; volumes 1-13)
(EISSN 1424-9634) Published periodically from 2001-2013.Table of Contents
Highlights from the Literature
Priority Briefs
Extracellular S100A9 Protein in Bone Marrow Supports Multiple Myeloma Survival by Stimulating Angiogenesis and Cytokine Secretion
Kim De Veirman; Nathan De Beule; Ken Maes; Eline Menu; Elke De Bruyne; Hendrik De Raeve; Karel Fostier; Jérôme Moreaux; Alboukadel Kassambara; Dirk Hose; Roy Heusschen; Helena Eriksson; Karin Vanderkerken; Els Van Valckenborgh
Research Articles
Customized Viral Immunotherapy for HPV-Associated Cancer
Matthew J. Atherton; Kyle B. Stephenson; Jonathan Pol; Fuan Wang; Charles Lefebvre; David F. Stojdl; Jake K. Nikota; Anna Dvorkin-Gheva; Andrew Nguyen; Lan Chen; Stephanie Johnson-Obaseki; Patrick J. Villeneuve; Jean-Simon Diallo; Jim Dimitroulakos; Yonghong Wan; Brian D. Lichty
Author Choice
Antigen-Presenting Intratumoral B Cells Affect CD4+ TIL Phenotypes in Non–Small Cell Lung Cancer Patients
Tullia C. Bruno; Peggy J. Ebner; Brandon L. Moore; Olivia G. Squalls; Katherine A. Waugh; Evgeniy B. Eruslanov; Sunil Singhal; John D. Mitchell; Wilbur A. Franklin; Daniel T. Merrick; Martin D. McCarter; Brent E. Palmer; Jeffrey A. Kern; Jill E. Slansky
The Antitumor Effects of Vaccine-Activated CD8+ T Cells Associate with Weak TCR Signaling and Induction of Stem-Like Memory T Cells
Sha Wu; Wei Zhu; Yibing Peng; Lan Wang; Yuan Hong; Lei Huang; Dayong Dong; Junping Xie; Todd Merchen; Edward Kruse; Zong Sheng Guo; David Bartlett; Ning Fu; Yukai He
Vaccine-activated CD8+ T cells that had weaker TCR signaling had stronger antitumor effects. Weak activation halted differentiation at the stem-like memory T-cell stage, generating more Tscm cells, and protected T effectors from antigen-induced exhaustion and apoptosis.
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