About the Cover
Tumors create havoc by making their own rules. How cancer cells may travel and seed a new site, such as the immune-privileged eye, is not always clear. A case of “Trojan horse” travel is described by Grajewski and colleagues starting on p. 92 in this issue of Cancer Immunology Research. A covert parotid carcinoma may have traveled to the aqueous humor of the eye by fusing with migratory phagocytic cells to create monocyte–macrophage Trojan horses. The eye's trabecular network trapped these cells (the yellow section, lower left, of the iris), and they proliferated, causing a rare type of carcinoma in the aqueous humor. Artwork is by Lewis Long.