Skip Nav Destination
Issues
1 November 2016
-
Cover Image
Cover Image
About the CoverClose Modal
Patients with familial adenomatous polyposis (FAP) have inflamed colons and have a high risk of colon cancer. These patients have defective retinoic acid (RA) metabolism that produces a local deficit of RA in the tumor milieu. Using a mouse model of FAP, decreased or absent RA encouraged disease progression, but inhibiting an enzyme that catabolizes RA ameliorated disease. One of the effects of increasing RA was to dampen the inflammatory phenotype of gut dendritic cells, and these cells were found to be crucial for adenoma formation. Read more in the article by Penny and colleagues starting on page 917 of this issue. The confocal microscopy image is of an FAP polyp, with red labeling an inhibitor of the RA metabolic pathway, CTBP1, and green denoting dendritic cells labeled with DC-SIGN (photo by HL Penny, of the Edgar G Engleman lab). Artwork by Lewis Long. - PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
ISSN 2326-6066
EISSN 2326-6074
Journal Archive
Cancer Immunology Research (2013-Present)
(ISSN 2326-6066) Published monthly since 2013.Cancer Immunity (2001-2013; volumes 1-13)
(EISSN 1424-9634) Published periodically from 2001-2013.Table of Contents
What We’re Reading
Masters of Immunology
Cancer Immunology Miniatures
Priority Brief
Classical Hodgkin Lymphoma with Reduced β2M/MHC Class I Expression Is Associated with Inferior Outcome Independent of 9p24.1 Status
Margaretha G.M. Roemer; Ranjana H. Advani; Robert A. Redd; Geraldine S. Pinkus; Yasodha Natkunam; Azra H. Ligon; Courtney F. Connelly; Christine J. Pak; Christopher D. Carey; Sarah E. Daadi; Bjoern Chapuy; Daphne de Jong; Richard T. Hoppe; Donna S. Neuberg; Margaret A. Shipp; Scott J. Rodig
Research Articles
Restoring Retinoic Acid Attenuates Intestinal Inflammation and Tumorigenesis in APCMin/+ Mice
Hweixian Leong Penny; Tyler R. Prestwood; Nupur Bhattacharya; Fionna Sun; Justin A. Kenkel; Matthew G. Davidson; Lei Shen; Luis A. Zuniga; E. Scott Seeley; Reetesh Pai; Okmi Choi; Lorna Tolentino; Jinshan Wang; Joseph L. Napoli; Edgar G. Engleman
MicroRNA let-7, T Cells, and Patient Survival in Colorectal Cancer
Ruoxu Dou; Reiko Nishihara; Yin Cao; Tsuyoshi Hamada; Kosuke Mima; Atsuhiro Masuda; Yohei Masugi; Yan Shi; Mancang Gu; Wanwan Li; Annacarolina da Silva; Katsuhiko Nosho; Xuehong Zhang; Jeffrey A. Meyerhardt; Edward L. Giovannucci; Andrew T. Chan; Charles S. Fuchs; Zhi Rong Qian; Shuji Ogino
Kinase Regulation of Human MHC Class I Molecule Expression on Cancer Cells
Elliott J. Brea; Claire Y. Oh; Eusebio Manchado; Sadna Budhu; Ron S. Gejman; George Mo; Patrizia Mondello; James E. Han; Casey A. Jarvis; David Ulmert; Qing Xiang; Aaron Y. Chang; Ralph J. Garippa; Taha Merghoub; Jedd D. Wolchok; Neal Rosen; Scott W. Lowe; David A. Scheinberg
Systemic GM-CSF Recruits Effector T Cells into the Tumor Microenvironment in Localized Prostate Cancer
Xiao X. Wei; Stephen Chan; Serena Kwek; Jera Lewis; Vinh Dao; Li Zhang; Matthew R. Cooperberg; Charles J. Ryan; Amy M. Lin; Terence W. Friedlander; Brian Rini; Christopher Kane; Jeffry P. Simko; Peter R. Carroll; Eric J. Small; Lawrence Fong
Targeted Next Generation Sequencing Identifies Markers of Response to PD-1 Blockade
Douglas B. Johnson; Garrett M. Frampton; Matthew J. Rioth; Erik Yusko; Yaomin Xu; Xingyi Guo; Riley C. Ennis; David Fabrizio; Zachary R. Chalmers; Joel Greenbowe; Siraj M. Ali; Sohail Balasubramanian; James X. Sun; Yuting He; Dennie T. Frederick; Igor Puzanov; Justin M. Balko; Justin M. Cates; Jeffrey S. Ross; Catherine Sanders; Harlan Robins; Yu Shyr; Vincent A. Miller; Philip J. Stephens; Ryan J. Sullivan; Jeffrey A. Sosman; Christine M. Lovly
Advertisement