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Cover Image
Cover Image
About the Cover
Many cell types can be infected with Epstein–Barr virus (EBV), but only B lymphocytes express the set of EBV-encoded proteins that induce proliferation. Expression of these viral proteins is restricted to a defined B-cell differentiation stage. Emergence of EBV-induced B-cell malignancies is suppressed by highly efficient immunologic surveillance mechanisms. In addition to cytotoxic T cell–mediated elimination of infected cells, the regulatory circuit of the immune response also operates in surveillance, particularly in the early phase of infection. This mechanism involves T cell–mediated regulation of B-cell differentiation, a phenomenon that can be demonstrated in vitro with experimentally infected B cells. The cover image (generated by Dr. Eahsan Rasul) comprises fluorescence micrographs of CBM1–Ral–STO cells treated with lymphokine IL21, a product of activated T cells. CBM1–Ral–STO is a lymphoblastoid cell line generated by in vitro infection of human cord blood mononuclear cells with EBV. IL21 pushes the cells to plasmocytoid differentiation as shown by the expression of Blimp–1, a plasma cell–specific marker. In these cells the EBV–encoded growth program is not expressed due to downregulation of EBNA–2, and consequently these EBV–infected cells cease to proliferate. Cells in the top two panels were stained with mouse anti–EBNA–2 mAb clone PE2 (green), and anti–LMP–1 mAb clone S–12 (red). Cells in the bottom two panels were stained with mouse anti–Blimp–1 mAb clone 3H2–E8 (green), and Dapi for nuclear DNA. For details, see the Masters of Immunology primer by Eva Klein and colleagues that begins on page 97 of this issue.
About the Master
Eva Fischer Klein, MD, PhD, is a professor emeritus and group leader in the Microbiology, Tumor and Cell Biology Center (MTC) of the Karolinska Institute, Stockholm, Sweden. Her pioneering contributions in experimental and clinical studies cover several aspects of malignancy including tumorigenesis, host immune responses, and the microenvironment. Guided by her work on virus-induced lymphomas in mice she began studies on Burkitt lymphoma in its initial stages when the Epstein–Bar virus (EBV) was discovered in Burkitt lymphoma tissues. EBV continues to be her main research focus. She has established a number of cell lines derived from African Burkitt lymphoma that are in use today.
Dr. Klein was born in Budapest, Hungary, in 1925. With the help of friends she survived the Holocaust (miraculously on a few occasions); immediately after the war she began medical studies at the University of Budapest, where she met Georg Klein, who became her husband. In the last days before the Iron Curtain descended on Hungary the couple moved to Stockholm. They both obtained positions as research students in the department of cell biology and genetics at the Karolinska Institute in 1948 under the tutelage of Professor Torbjörn Caspersson. The black and white photograph was taken in 1948 upon their arrival at the Karolinska. (For more details, see the article by G. Klein and E. Klein in Ann Rev Immunol 1989;7:1–33.)
Professor Klein received her MD in 1955 and her PhD in 1965. Her PhD thesis work was on the transformation of solid tumors into ascites tumors, focusing on the evolution of tumor cell populations based on variation and selection. This theme recurs in her present studies in chronic lymphocytic leukemia. Dr. Klein became a professor of tumor biology in 1979 and professor emeritus in 1993. She has mentored many students, some of whom have reached top positions in Sweden and internationally.
Dr. Klein has published over 500 papers. She has served as an editor for Seminars in Cancer Biology. She is a member of the Royal Swedish Academy of Sciences, a foreign member of the Hungarian Academy of Sciences and the Hungarian Immunological Society, the first honorary member of the Israel Immunological Society, and a fellow of the European Union Contra Cancer. She was elected as a fellow of the American Association for Cancer Research Academy in 2013.
Professor Eva Klein has received many awards and honors, including honorary doctorates from the University of Nebraska and the Ohio State University; the Bertha Goldblatt Teplitz Award from the Ann Langer Cancer Research Foundation; the inaugural William B. Coley Award in Tumor Immunology from the Cancer Research Institute; the Björken Prize from Uppsala University; the Nordic Prize of the Erik Fernström Foundation of Lund University; the Thomas P. Infusino Prize and Lectureship in Cancer Causation and Epidemiology from the Lautenberg Center for General and Tumor Immunology; the Orden Nacional al Mérito de la República de Colombia; and the Mendel Honorary Medal for Merit in the Biological Sciences from the Academy of Sciences of the Czech Republic. She was declared the 2006 MTC Scientist of the Year, and in 2010 she received the Karolinska Institute's 200-Year Anniversary Silver Medal for Medical Research. The Kleins have one son, who is a mathematician, and two daughters, one an MD and the other a playwright. - PDF Icon PDF LinkTable of Contents
Cancer Immunology Research
Cancer Immunology Research, launched in 2013 with Glenn Dranoff as founding Editor-in-Chief, is published by the AACR. The Journal illuminates the interplay between tumors and the immune system, with Robert D. Schreiber and Philip D. Greenberg serving as the Editors-in-Chief.
Table of Contents
Masters of Immunology
Cancer Immunology at the Crossroads: Microbiology
Cancer Immunology Miniatures
Priority Brief
Research Articles
Tasquinimod Modulates Suppressive Myeloid Cells and Enhances Cancer Immunotherapies in Murine Models
Combination of 4-1BB Agonist and PD-1 Antagonist Promotes Antitumor Effector/Memory CD8 T Cells in a Poorly Immunogenic Tumor Model
Extensive Profiling of the Expression of the Indoleamine 2,3-Dioxygenase 1 Protein in Normal and Tumoral Human Tissues
B7-H4 Expression by Nonhematopoietic Cells in the Tumor Microenvironment Promotes Antitumor Immunity
Correction
Journal Archive
Cancer Immunology Research
(2013-Present)Published monthly since 2013.
(ISSN 2326-6066)
Cancer Immunity
(2001-2013; volumes 1-13)Published periodically from 2001-2013.
(EISSN 1424-9634)
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