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Neighborhood Watch: Imaging the Tumor Immune Microenvironment

This collection of articles published in 2021 and 2022 in Cancer Immunology Research, includes research studies that showcase an array of advanced imaging techniques that are being used to learn more about the tumor immune landscape, providing new insight into the spatial relationships and complex phenotypes of the immune cells during tumor development and response to therapy. We hope you enjoy this collection!

Research Articles

Imaging α-GalCer–Activated iNKT Cells in a Hepatic Metastatic Environment

Liane Babes; Raymond Shim; Paul Kubes

Doi: 10.1158/2326-6066.CIR-21-0445

Research Articles

PD-1/PD-L1–Associated Immunoarchitectural Patterns Stratify Pancreatic Cancer Patients into Prognostic/Predictive Subgroups

Eva Karamitopoulou; Andreas Andreou; Aurélie Pahud de Mortanges; Marianne Tinguely; Beat Gloor; Aurel Perren

Doi: 10.1158/2326-6066.CIR-21-0144

Research Articles

CAR T-cell Entry into Tumor Islets Is a Two-Step Process Dependent on IFNγ and ICAM-1

Chahrazade Kantari-Mimoun; Sarah Barrin; Lene Vimeux; Sandrine Haghiri; Claire Gervais; Sandy Joaquina; Joerg Mittelstaet; Nadine Mockel-Tenbrinck; Ali Kinkhabwala; Diane Damotte; Audrey Lupo; Mathilde Sibony; Marco Alifano; Elisabetta Dondi; Nadège Bercovici; Alain Trautmann; Andrew D. Kaiser; Emmanuel Donnadieu

Doi: 10.1158/2326-6066.CIR-20-0837

Priority Brief

Spatial UMAP and Image Cytometry for Topographic Immuno-oncology Biomarker Discovery

Nicolas A. Giraldo; Sneha Berry; Etienne Becht; Deniz Ates; Kara M. Schenk; Elizabeth L. Engle; Benjamin Green; Peter Nguyen; Abha Soni; Julie E. Stein; Farah Succaria; Aleksandra Ogurtsova; Haiying Xu; Raphael Gottardo; Robert A. Anders; Evan J. Lipson; Ludmila Danilova; Alexander S. Baras; Janis M. Taube

Doi: 10.1158/2326-6066.CIR-21-0015

Research Articles

The Prognostic Role of Macrophage Polarization in the Colorectal Cancer Microenvironment

Juha P. Väyrynen; Koichiro Haruki; Mai Chan Lau; Sara A. Väyrynen; Rong Zhong; Andressa Dias Costa; Jennifer Borowsky; Melissa Zhao; Kenji Fujiyoshi; Kota Arima; Tyler S. Twombly; Junko Kishikawa; Simeng Gu; Saina Aminmozaffari; Shanshan Shi; Yoshifumi Baba; Naohiko Akimoto; Tomotaka Ugai; Annacarolina Da Silva; Jennifer L. Guerriero; Mingyang Song; Kana Wu; Andrew T. Chan; Reiko Nishihara; Charles S. Fuchs; Jeffrey A. Meyerhardt; Marios Giannakis; Shuji Ogino; Jonathan A. Nowak

Doi: 10.1158/2326-6066.CIR-20-0527

Neighborhood Watch: Imaging the Tumor Immune Microenvironment

AACR Journals

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