Exon–TE splicing junctions are a source of tumor-specific antigens (from Sukhjinder via Pixahive)

Emerging evidence indicates that tumor-associated MHC-I–presented peptides can be generated from noncanonical transcripts. Two studies expand the landscape of such transcripts to include transcripts generated by mRNA splicing events between exons and transposable elements (TE). In patients with non–small cell lung cancer, Merlotti et al. identify CD8+ T cells that recognize tumor-specific HLA-I–bound peptides encoded by transcripts generated from exon–TE splicing junctions. Burbage et al. find that immunization with peptides derived from exon–TE splicing junctions slows tumor growth in several mouse tumor models. Together, the data suggest these peptides could be harnessed to develop therapeutic cancer vaccines or TCR-based cell therapies.

Merlotti A, …, Amigorena S. Sci Immunol 2023 February 3;8:eabm6359.

Burbage M, …, Amigorena S. Sci Immunol 2023 February 3;8:eabm6360.

Tuned-up CARs can improve therapeutic efficacy (from Ari Helminen via Flickr)

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