Human fibrinogen E domain (from 5-HT2AR via Wikimedia Commons)

Incomplete surgical removal of a solid tumor increases a patient's risk for local tumor recurrence. Using xenograft models of incomplete excision of pancreatic ductal adenocarcinoma (PDAC) and triple-negative breast cancer (TNBC), Uslu and colleagues show that intra-operative application of mesothelin-targeted chimeric antigen receptor (CAR) T cells in a fibrin glue–based carrier results in clearance of residual tumor cells and increased survival compared with the same application of the CAR T cells into the tumor cavity in the absence of fibrin gel. The treatment had limited on-target off-tumor toxicity and did not lead to wound healing complications, supporting its clinical evaluation.

Uslu U, …, June CH. Sci Adv 2023 January 11;9:eade2526.

Neutrophil (from Blausen Medical via Wikimedia Commons)

Neutrophils have a complex role in cancer. They often promote tumor growth and metastasis but can exert antitumor activity in certain contexts. Using...

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