IFNγ Helps CBLB-Deficient CD8⁺ T Cells to Put Up Resistance to Tregs Available to Purchase

In this issue, Han and colleagues demonstrate in preclinical cancer models that genetic deletion of the E3 ubiquitin ligase Cbl proto-oncogene B (CBLB) in adoptively transferred CD8⁺ T cells induces resistance to regulatory T cells. CBLB deletion induces IFNγ and downmodulates TGFβ/SMAD signaling. This ultimately enforces these cells to be way more effective against various cancers.

See related article by Han et al., p. 437 (4).