Nanotubes mediate mitochondrial transfer to tumor cells (by Michael Ströck via Wikimedia Commons)

Tumors use various mechanisms to escape immune detection in the tumor microenvironment (TME). Saha et al. show that tumor cells form nanotubes that physically interact with immune cells in the breast cancer TME. Mitochondria are then transferred from immune cells to tumor cells, leading to tumor metabolic enhancement and loss of specific immune-cell subsets needed for antitumor responses. Targeting nanotube formation reversed these effects and when combined with immune checkpoint blockade, resulted in improved outcomes in a murine breast cancer model. The data highlight a new immune “hijacking” mechanism that tumors cells could use to promote cancer progression.

Saha T, …, Sengupta S. Nat Nanotechnol 2021 Nov 18. DOI: 10.1038/s41565-021-01000-4.

Lung cancers can become infiltrated by dysfunctional CD8+ T cells (by Eric Synder via NCI Visuals Online)

Many non–small cell lung cancers (NSCLC) infiltrated with CD8...

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