...; Jillian Phallen; Robert B. Scharpf; Amy K. Kim; Victor E. Velculescu Liver cancer is a major cause of cancer mortality worldwide. Screening individuals at high risk, including those with cirrhosis and viral hepatitis, provides an avenue for improved survival, but current screening methods are inadequate...

... Anagnostou, Alexander Baras, Julie Brahmer, Christopher Gocke, Robert B. Scharpf, Jessica Tao, Victor E. Velculescu; Medical University of South Carolina, Charleston, SC: Raymond DuBois; Memorial Sloan Kettering Cancer Center, New York, NY: Maria E. Arcila, Ryma Benayed, Michael F. Berger...

... peptide TG3 for primary AMLs). Cell viability was assessed 72 hours after treatment using CellTiter-Glo cell viability assay according to the manufacturer's protocol (Promega). Luminescence was measured on the Victor X3 plate reader (PerkinElmer). Rescue experiments in MUTZ3 cells were performed...

... to detect early-stage tumors. Overall, it identified 62% of 138 patients whose tumors were stage I or II. Victor Velculescu, MD, PhD, of Johns Hopkins University School of Medicine in Baltimore, MD, and colleagues developed a technique to profile the smaller amounts of ctDNA present in early-stage...

.... Sonke; Jean Charles Soria; Parin Sripakdeevong; Natalie H. Stickle; Thomas P. Stricker; Shawn M. Sweeney; Barry S. Taylor; Jelle J. ten Hoeve; Stacy B. Thomas; Eliezer M. Van Allen; Laura J. Van 'T Veer; Tony van de Velde; Harm van Tinteren; Victor E. Velculescu; Carl Virtanen; Emile E. Voest; Lucy L...

...; Peter Illei; Qing Kay Li; Edward Gabrielson; Malcolm V. Brock; Cynthia A. Zahnow; Stephen B. Baylin; Robert B. Scharpf; Julie R. Brahmer; Rachel Karchin; Drew M. Pardoll; Victor E. Velculescu Immune checkpoint inhibitors have shown significant therapeutic responses against tumors containing increased...

.... However, de novo or acquired resistance is common. Although mutations in KRAS and several other genes promote resistance to the EGFR inhibitors, it is likely that additional mechanisms exist. To search for new mechanisms, Victor Velculescu, MD, PhD, of Johns Hopkins School...

.... “There's been a lack of appreciation of the utility of including DNA analyses from matched normal tissue,” said senior author Victor Velculescu, MD, PhD, at a press briefing on April 14. Velculescu and his group evaluated tumor and normal tissue samples from 815 patients with 15 different cancer types...

... , Rowan   AJ , Salm   MP , Varela   I , et al   Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing . Nat Genet   2014 ; 46 : 225 – 33 . 3. Vogelstein   B , Papadopoulos   N , Velculescu   VE , Zhou   S , Diaz   LA...

...Daniel A. Haber; Victor E. Velculescu The ability to study nonhematologic cancers through noninvasive sampling of blood is one of the most exciting and rapidly advancing fields in cancer diagnostics. This has been driven both by major technologic advances, including the isolation of intact cancer...

... cancer,” says Victor Velculescu, MD, PhD, a coauthor of the study and professor of oncology and codirector of the Cancer Biology Program at Johns Hopkins in Baltimore, MD. He says that existing blood tests for cancer depend on protein levels that can rise and fall based on events other than tumor growth...

...; Giorgio Corti; Alessio Amatu; Marcello Gambacorta; Luis A. Diaz, Jr; Mark Sausen; Victor E. Velculescu; Paolo Comoglio; Livio Trusolino; Federica Di Nicolantonio; Silvia Giordano; Salvatore Siena EGF receptor (EGFR)-targeted monoclonal antibodies are effective in a subset of metastatic colorectal cancers...

...Nishant Agrawal; Yuchen Jiao; Chetan Bettegowda; Susan M. Hutfless; Yuxuan Wang; Stefan David; Yulan Cheng; William S. Twaddell; Nyan L. Latt; Eun J. Shin; Li-Dong Wang; Liang Wang; Wancai Yang; Victor E. Velculescu; Bert Vogelstein; Nickolas Papadopoulos; Kenneth W. Kinzler; Stephen J. Meltzer...

...Nicholas J. Roberts; Yuchen Jiao; Jun Yu; Levy Kopelovich; Gloria M. Petersen; Melissa L. Bondy; Steven Gallinger; Ann G. Schwartz; Sapna Syngal; Michele L. Cote; Jennifer Axilbund; Richard Schulick; Syed Z. Ali; James R. Eshleman; Victor E. Velculescu; Michael Goggins; Bert Vogelstein; Nickolas...