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Journal Articles

Neoadjuvant Ipilimumab + Nivolumab + Chemotherapy Enhances Pathologic Responses

Journal: Cancer Discovery
Cancer Discov (2023) 13 (6): OF11.
DOI: https://doi.org/10.1158/2159-8290.CD-RW2023-047
Published: 02 June 2023
... NEOSTAR trial. Nat Med 2023;29:593–604 . Note: Research Watch is written by Cancer Discovery editorial staff. Readers are encouraged to consult the original articles for full details. For more Research Watch, visit Cancer Discovery online at http...
View article titled, Neoadjuvant Ipilimumab + Nivolumab + Chemotherapy Enhances Pathologic Responses
Journal Articles

CD8+ T Cells in the Lymph Node Play a Key Role in Immunotherapy Response

Journal: Cancer Discovery
Cancer Discov (2023) 13 (6): OF12.
DOI: https://doi.org/10.1158/2159-8290.CD-RW2023-048
Published: 02 June 2023
... Watch is written by Cancer Discovery editorial staff. Readers are encouraged to consult the original articles for full details. For more Research Watch, visit Cancer Discovery online at http://cancerdiscovery.aacrjournals.org/CDNews . ...
View article titled, CD8<sup>+</sup> T Cells in the Lymph Node Play a Key Role in Immunotherapy Response
Journal Articles

Driver Events of Gastric Cancer Differ According to Subtype and Ancestry

Journal: Cancer Discovery
Cancer Discov (2023) 13 (6): 1283.
DOI: https://doi.org/10.1158/2159-8290.CD-RW2023-049
Published: 02 June 2023
... . Note: Research Watch is written by Cancer Discovery editorial staff. Readers are encouraged to consult the original articles for full details. For more Research Watch, visit Cancer Discovery online at http://cancerdiscovery.aacrjournals.org/CDNews . ...
View article titled, Driver Events of Gastric Cancer Differ According to Subtype and Ancestry
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Journal Articles

Microbiome Imbalance Promotes Colorectal Cancer via Urea Cycle Activation

Journal: Cancer Discovery
Cancer Discov (2023) 13 (6): OF13.
DOI: https://doi.org/10.1158/2159-8290.CD-RW2023-050
Published: 02 June 2023
...-microbiota maladaptation driving colorectal tumorigenesis. Cell Metab 2023 Mar 23 [Epub ahead of print] . Note: Research Watch is written by Cancer Discovery editorial staff. Readers are encouraged to consult the original articles for full details. For more Research Watch...
View article titled, Microbiome Imbalance Promotes Colorectal Cancer via Urea Cycle Activation
Journal Articles

Pediatric Tumor Transcriptome Analysis Enables Diagnostic Classification

Journal: Cancer Discovery
Cancer Discov (2023) 13 (6): 1284.
DOI: https://doi.org/10.1158/2159-8290.CD-RW2023-051
Published: 02 June 2023
... the transcriptome-based diagnosis of pediatric cancers. Comitani F, Nash JO, Cohen-Gogo S, Chang AI, Wen TT, Maheshwari A, et al. Diagnostic classification of childhood cancer using multiscale transcriptomics. Nat Med 2023;29:656–66 . Note: Research Watch is written by Cancer...
View article titled, Pediatric Tumor Transcriptome Analysis Enables Diagnostic Classification
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Journal Articles

Tumor Cells Alter NK Cell Surface Topology for Immune Evasion

Journal: Cancer Discovery
Cancer Discov (2023) 13 (6): 1283.
DOI: https://doi.org/10.1158/2159-8290.CD-RW2023-052
Published: 02 June 2023
... by altering the surface topology of NK cells. Nat Immunol 2023;24:802–13 . Note: Research Watch is written by Cancer Discovery editorial staff. Readers are encouraged to consult the original articles for full details. For more Research Watch, visit Cancer Discovery...
View article titled, Tumor Cells Alter NK Cell Surface Topology for Immune Evasion
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Journal Articles

The Evolutionary Duration of Neuroblastoma Predicts Clinical Outcome

Journal: Cancer Discovery
Cancer Discov (2023) 13 (6): 1284.
DOI: https://doi.org/10.1158/2159-8290.CD-RW2023-054
Published: 02 June 2023
...–30 . Note: Research Watch is written by Cancer Discovery editorial staff. Readers are encouraged to consult the original articles for full details. For more Research Watch, visit Cancer Discovery online at http://cancerdiscovery.aacrjournals.org/CDNews . ...
View article titled, The Evolutionary Duration of Neuroblastoma Predicts Clinical Outcome
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Journal Articles

Pancreatic Cancer Is Dependent on De Novo Ornithine Synthesis from Glutamine

Journal: Cancer Discovery
Cancer Discov (2023) 13 (6): 1286.
DOI: https://doi.org/10.1158/2159-8290.CD-RW2023-053
Published: 02 June 2023
... cancer. Nature 2023;616:339–47 . Note: Research Watch is written by Cancer Discovery editorial staff. Readers are encouraged to consult the original articles for full details. For more Research Watch, visit Cancer Discovery online at http...
View article titled, Pancreatic Cancer Is Dependent on De Novo Ornithine Synthesis from Glutamine
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Journal Articles

STING Inhibits the Reactivation of Dormant Lung Cancer Metastasis

Journal: Cancer Discovery
Cancer Discov (2023) 13 (6): 1285.
DOI: https://doi.org/10.1158/2159-8290.CD-RW2023-056
Published: 02 June 2023
... the reactivation of dormant metastasis in lung adenocarcinoma. Nature 2023;616:806–13 . Note: Research Watch is written by Cancer Discovery editorial staff. Readers are encouraged to consult the original articles for full details. For more Research Watch, visit Cancer...
View article titled, STING Inhibits the Reactivation of Dormant Lung Cancer Metastasis
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Journal Articles

Neutrophils Are Critical to the Effectiveness of Cancer Immunotherapy

Journal: Cancer Discovery
Cancer Discov (2023) 13 (6): 1285.
DOI: https://doi.org/10.1158/2159-8290.CD-RW2023-055
Published: 02 June 2023
...: Research Watch is written by Cancer Discovery editorial staff. Readers are encouraged to consult the original articles for full details. For more Research Watch, visit Cancer Discovery online at http://cancerdiscovery.aacrjournals.org/CDNews . ...
View article titled, Neutrophils Are Critical to the Effectiveness of Cancer Immunotherapy
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Journal Articles

Belzutifan Plus Cabozantinib Is Effective in Immunotherapy-Treated Renal Cell Carcinoma

Journal: Cancer Discovery
Cancer Discov (2023) 13 (6): OF14.
DOI: https://doi.org/10.1158/2159-8290.CD-RW2023-057
Published: 02 June 2023
... cell carcinoma previously treated with immunotherapy: an open-label, single-arm, phase 2 study. Lancet Oncol 2023 Mar 31 [Epub ahead of print] . Note: Research Watch is written by Cancer Discovery editorial staff. Readers are encouraged to consult the original articles...
View article titled, Belzutifan Plus Cabozantinib Is Effective in Immunotherapy-Treated Renal Cell Carcinoma
Journal Articles

Air Pollution Promotes Oncogenic Expansion of Mutant Lung Progenitor Cells

Journal: Cancer Discovery
Cancer Discov (2023) 13 (6): 1286.
DOI: https://doi.org/10.1158/2159-8290.CD-RW2023-058
Published: 02 June 2023
... . Note: Research Watch is written by Cancer Discovery editorial staff. Readers are encouraged to consult the original articles for full details. For more Research Watch, visit Cancer Discovery online at http://cancerdiscovery.aacrjournals.org/CDNews . ...
View article titled, Air Pollution Promotes Oncogenic Expansion of Mutant Lung Progenitor Cells
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Journal Articles

Telomere Shortening Induces T-cell Dysfunction and Squamous Cell Cancers

Journal: Cancer Discovery
Cancer Discov (2023) 13 (6): 1287.
DOI: https://doi.org/10.1158/2159-8290.CD-RW2023-059
Published: 02 June 2023
...:807–17 . Note: Research Watch is written by Cancer Discovery editorial staff. Readers are encouraged to consult the original articles for full details. For more Research Watch, visit Cancer Discovery online at http://cancerdiscovery.aacrjournals.org/CDNews . ...
View article titled, Telomere Shortening Induces T-cell Dysfunction and Squamous Cell Cancers
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Journal Articles

Lymphocyte Interaction Networks Drive Lung Cancer Immunosurveillance

Journal: Cancer Discovery
Cancer Discov (2023) 13 (6): 1287.
DOI: https://doi.org/10.1158/2159-8290.CD-RW2023-060
Published: 02 June 2023
.... Gaglia G, Burger ML, Ritch CC, Rammos D, Dai Y, Crossland GE, et al. Lymphocyte networks are dynamic cellular communities in the immunoregulatory landscape of lung adenocarcinoma. Cancer Cell 2023;41:871–86 . Note: Research Watch is written by Cancer Discovery editorial...
View article titled, Lymphocyte Interaction Networks Drive Lung Cancer Immunosurveillance
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Journal Articles

An Antitumor T-cell Response Was Induced by Engineered Commensal Bacteria

Journal: Cancer Discovery
Cancer Discov (2023) 13 (6): OF15.
DOI: https://doi.org/10.1158/2159-8290.CD-RW2023-061
Published: 02 June 2023
... responses against melanoma. Science 2023;380:203–10 . Note: Research Watch is written by Cancer Discovery editorial staff. Readers are encouraged to consult the original articles for full details. For more Research Watch, visit Cancer Discovery online at http...
View article titled, An Antitumor T-cell Response Was Induced by Engineered Commensal Bacteria
Journal Articles

Uridine Utilization Drives Pancreatic Cancer in Low-Nutrient Conditions

Journal: Cancer Discovery
Cancer Discov OF1.
DOI: https://doi.org/10.1158/2159-8290.CD-RW2023-082
Published: 02 June 2023
... therapeutic vulnerability. Nwosu ZC, Ward MH, Sajjakulnukit P, Poudel P, Ragulan C, Kasperek S, et al. Uridine-derived ribose fuels glucose-restricted pancreatic cancer. Nature 2023 May 17 [Epub ahead of print] . Note: Research Watch is written by Cancer Discovery...
View article titled, Uridine Utilization Drives Pancreatic Cancer in Low-Nutrient Conditions
Journal Articles

DNX-2401 plus Pembrolizumab Is Safe in Recurrent Glioblastoma

Journal: Cancer Discovery
Cancer Discov OF1.
DOI: https://doi.org/10.1158/2159-8290.CD-RW2023-083
Published: 02 June 2023
... of patients with GBM. Nassiri F, Patil V, Yefet LS, Singh O, Liu J, Dang RMA, et al. Oncolytic DNX-2401 virotherapy plus pembrolizumab in recurrent glioblastoma: a phase 1/2 trial. Nat Med 2023 May 15 [Epub ahead of print] . Note: Research Watch is written by Cancer...
View article titled, DNX-2401 plus Pembrolizumab Is Safe in Recurrent Glioblastoma
Journal Articles

Estrogen-Induced Translocations Precede Amplification in Breast Cancer

Journal: Cancer Discovery
Cancer Discov OF1.
DOI: https://doi.org/10.1158/2159-8290.CD-RW2023-084
Published: 02 June 2023
...] . Note: Research Watch is written by Cancer Discovery editorial staff. Readers are encouraged to consult the original articles for full details. For more Research Watch, visit Cancer Discovery online at http://cancerdiscovery.aacrjournals.org/CDNews . ...
View article titled, Estrogen-Induced Translocations Precede Amplification in Breast Cancer
Journal Articles

Genomic Profiling of Neuroblastoma Reveals Key Evolutionary Features

Journal: Cancer Discovery
Cancer Discov OF1.
DOI: https://doi.org/10.1158/2159-8290.CD-RW2023-077
Published: 26 May 2023
... evolution during metastatic spread in high-risk neuroblastoma. Nat Genet 2023 May 11 [Epub ahead of print] . Note: Research Watch is written by Cancer Discovery editorial staff. Readers are encouraged to consult the original articles for full details. For more Research Watch...
View article titled, Genomic Profiling of Neuroblastoma Reveals Key Evolutionary Features
Journal Articles

AAV-Mediated Gene Delivery of LIGHT Prolongs Survival in Glioblastoma

Journal: Cancer Discovery
Cancer Discov OF1.
DOI: https://doi.org/10.1158/2159-8290.CD-RW2023-078
Published: 26 May 2023
... promotes anti-tumor immunity in glioma. Cancer Cell 2023 May 11 [Epub ahead of print] . Note: Research Watch is written by Cancer Discovery editorial staff. Readers are encouraged to consult the original articles for full details. For more Research Watch, visit Cancer...
View article titled, AAV-Mediated Gene Delivery of LIGHT Prolongs Survival in Glioblastoma