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William R. Sellers
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Journal Articles

Discovery and Optimization of HKT288, a Cadherin-6–Targeting ADC for the Treatment of Ovarian and Renal Cancers

Carl U. Bialucha, Scott D. Collins, Xiao Li, Parmita Saxena, Xiamei Zhang, Clemens Dürr, Bruno Lafont, Pierric Prieur, Yeonju Shim, Rebecca Mosher, David Lee, Lance Ostrom, Tiancen Hu, Sanela Bilic, Ivana Liric Rajlic, Vladimir Capka, Wei Jiang, Joel P. Wagner, GiNell Elliott, Artur Veloso, Jessica C. Piel, Meghan M. Flaherty, Keith G. Mansfield, Emily K. Meseck, Tina Rubic-Schneider, Anne Serdakowski London, William R. Tschantz, Markus Kurz, Duc Nguyen, Aaron Bourret, Matthew J. Meyer, Jason E. Faris, Mary J. Janatpour, Vivien W. Chan, Nicholas C. Yoder, Kalli C. Catcott, Molly A. McShea, Xiuxia Sun, Hui Gao, Juliet Williams, Francesco Hofmann, Jeffrey A. Engelman, Seth A. Ettenberg, William R. Sellers, Emma Lees
Journal: Cancer Discovery
Cancer Discov (2017) 7 (9): 1030–1045.
https://doi.org/10.1158/2159-8290.CD-16-1414
Published: 31 August 2017
View article titled, Discovery and Optimization of HKT288, a Cadherin-6–Targeting ADC for the Treatment of Ovarian and Renal Cancers
Open the PDF for Discovery and Optimization of HKT288, a Cadherin-6–Targeting ADC for the Treatment of Ovarian and Renal Cancers in another window
Includes: Supplementary data
Journal Articles

CRISPR Screens Provide a Comprehensive Assessment of Cancer Vulnerabilities but Generate False-Positive Hits for Highly Amplified Genomic Regions

Diana M. Munoz, Pamela J. Cassiani, Li Li, Eric Billy, Joshua M. Korn, Michael D. Jones, Javad Golji, David A. Ruddy, Kristine Yu, Gregory McAllister, Antoine DeWeck, Dorothee Abramowski, Jessica Wan, Matthew D. Shirley, Sarah Y. Neshat, Daniel Rakiec, Rosalie de Beaumont, Odile Weber, Audrey Kauffmann, E. Robert McDonald, III, Nicholas Keen, Francesco Hofmann, William R. Sellers, Tobias Schmelzle, Frank Stegmeier, Michael R. Schlabach
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2016) 6 (8): 900–913.
https://doi.org/10.1158/2159-8290.CD-16-0178
Published: 01 August 2016
View article titled, CRISPR Screens Provide a Comprehensive Assessment of Cancer Vulnerabilities but Generate False-Positive Hits for Highly Amplified Genomic Regions
Open the PDF for CRISPR Screens Provide a Comprehensive Assessment of Cancer Vulnerabilities but Generate False-Positive Hits for Highly Amplified Genomic Regions in another window
Includes: Supplementary data
Journal Articles

An F876L Mutation in Androgen Receptor Confers Genetic and Phenotypic Resistance to MDV3100 (Enzalutamide)

Manav Korpal, Joshua M. Korn, Xueliang Gao, Daniel P. Rakiec, David A. Ruddy, Shivang Doshi, Jing Yuan, Steve G. Kovats, Sunkyu Kim, Vesselina G. Cooke, John E. Monahan, Frank Stegmeier, Thomas M. Roberts, William R. Sellers, Wenlai Zhou, Ping Zhu
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2013) 3 (9): 1030–1043.
https://doi.org/10.1158/2159-8290.CD-13-0142
Published: 09 September 2013
View article titled, An F876L Mutation in Androgen Receptor Confers Genetic and Phenotypic Resistance to MDV3100 (Enzalutamide)
Open the PDF for An F876L Mutation in Androgen Receptor Confers Genetic and Phenotypic Resistance to MDV3100 (Enzalutamide) in another window
Includes: Supplementary data
Journal Articles

FGFR Genetic Alterations Predict for Sensitivity to NVP-BGJ398, a Selective Pan-FGFR Inhibitor

Vito Guagnano, Audrey Kauffmann, Simon Wöhrle, Christelle Stamm, Moriko Ito, Louise Barys, Astrid Pornon, Yao Yao, Fang Li, Yun Zhang, Zhi Chen, Christopher J. Wilson, Vincent Bordas, Mickaël Le Douget, L. Alex Gaither, Jason Borawski, John E. Monahan, Kavitha Venkatesan, Thomas Brümmendorf, David M. Thomas, Carlos Garcia-Echeverria, Francesco Hofmann, William R. Sellers, Diana Graus-Porta
Journal: Cancer Discovery
Cancer Discov (2012) 2 (12): 1118–1133.
https://doi.org/10.1158/2159-8290.CD-12-0210
Published: 09 December 2012
View article titled, FGFR Genetic Alterations Predict for Sensitivity to NVP-BGJ398, a Selective Pan-FGFR Inhibitor
Open the PDF for FGFR Genetic Alterations Predict for Sensitivity to NVP-BGJ398, a Selective Pan-FGFR Inhibitor in another window
Includes: Supplementary data
Journal Articles

Rescue Screens with Secreted Proteins Reveal Compensatory Potential of Receptor Tyrosine Kinases in Driving Cancer Growth

Fred Harbinski, Vanessa J. Craig, Sneha Sanghavi, Douglas Jeffery, Lijuan Liu, Kelly Ann Sheppard, Sabrina Wagner, Christelle Stamm, Andreas Buness, Christian Chatenay-Rivauday, Yao Yao, Feng He, Chris X. Lu, Vito Guagnano, Thomas Metz, Peter M. Finan, Francesco Hofmann, William R. Sellers, Jeffrey A. Porter, Vic E. Myer, Diana Graus-Porta, Christopher J. Wilson, Alan Buckler, Ralph Tiedt
Journal: Cancer Discovery
Cancer Discov (2012) 2 (10): 948–959.
https://doi.org/10.1158/2159-8290.CD-12-0237
Published: 14 October 2012
View article titled, Rescue Screens with Secreted Proteins Reveal Compensatory Potential of Receptor Tyrosine Kinases in Driving Cancer Growth
Open the PDF for Rescue Screens with Secreted Proteins Reveal Compensatory Potential of Receptor Tyrosine Kinases in Driving Cancer Growth in another window
Includes: Supplementary data
Journal Articles

Modulation of Activation-Loop Phosphorylation by JAK Inhibitors Is Binding Mode Dependent

Rita Andraos, Zhiyan Qian, Débora Bonenfant, Joëlle Rubert, Eric Vangrevelinghe, Clemens Scheufler, Fanny Marque, Catherine H. Régnier, Alain De Pover, Hugues Ryckelynck, Neha Bhagwat, Priya Koppikar, Aviva Goel, Lorenza Wyder, Gisele Tavares, Fabienne Baffert, Carole Pissot-Soldermann, Paul W. Manley, Christoph Gaul, Hans Voshol, Ross L. Levine, William R. Sellers, Francesco Hofmann, Thomas Radimerski
Journal: Cancer Discovery
Cancer Discov (2012) 2 (6): 512–523.
https://doi.org/10.1158/2159-8290.CD-11-0324
Published: 07 June 2012
View article titled, Modulation of Activation-Loop Phosphorylation by JAK Inhibitors Is Binding Mode Dependent
Open the PDF for Modulation of Activation-Loop Phosphorylation by JAK Inhibitors Is Binding Mode Dependent in another window
Includes: Supplementary data