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Timothy P. Heffernan
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Journal Articles

Mechanisms of Resistance to Oncogenic KRAS Inhibition in Pancreatic Cancer

Open Access
Julien Dilly, Megan T. Hoffman, Laleh Abbassi, Ziyue Li, Francesca Paradiso, Brendan D. Parent, Connor J. Hennessey, Alexander C. Jordan, Micaela Morgado, Shatavisha Dasgupta, Giselle A. Uribe, Annan Yang, Kevin S. Kapner, Felix P. Hambitzer, Li Qiang, Hanrong Feng, Jacob Geisberg, Junning Wang, Kyle E. Evans, Hengyu Lyu, Aislyn Schalck, Ningping Feng, Anastasia M. Lopez, Christopher A. Bristow, Michael P. Kim, Kimal I. Rajapakshe, Vahid Bahrambeigi, Jennifer A. Roth, Kavita Garg, Paola A. Guerrero, Ben Z. Stanger, Simona Cristea, Scott W. Lowe, Timour Baslan, Eliezer M. Van Allen, Joseph D. Mancias, Emily Chan, Abraham Anderson, Yuliya V. Katlinskaya, Alex K. Shalek, David S. Hong, Shubham Pant, Jill Hallin, Kenna Anderes, Peter Olson, Timothy P. Heffernan, Seema Chugh, James G. Christensen, Anirban Maitra, Brian M. Wolpin, Srivatsan Raghavan, Jonathan A. Nowak, Peter S. Winter, Stephanie K. Dougan, Andrew J. Aguirre
Journal: Cancer Discovery
Cancer Discov (2024) 14 (11): 2135–2161.
https://doi.org/10.1158/2159-8290.CD-24-0177
Published: 01 November 2024
View articletitled, Mechanisms of Resistance to Oncogenic KRAS Inhibition in Pancreatic Cancer
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Includes: Supplementary data
Journal Articles

Oncogenic KRAS Recruits an Expansive Transcriptional Network through Mutant p53 to Drive Pancreatic Cancer Metastasis

Available to Purchase
Michael P. Kim, Xinqun Li, Jenying Deng, Yun Zhang, Bingbing Dai, Kendra L. Allton, Tara G. Hughes, Christian Siangco, Jithesh J. Augustine, Ya'an Kang, Joy M. McDaniel, Shunbin Xiong, Eugene J. Koay, Florencia McAllister, Christopher A. Bristow, Timothy P. Heffernan, Anirban Maitra, Bin Liu, Michelle C. Barton, Amanda R. Wasylishen, Jason B. Fleming, Guillermina Lozano
Journal: Cancer Discovery
Cancer Discov (2021) 11 (8): 2094–2111.
https://doi.org/10.1158/2159-8290.CD-20-1228
Published: 01 August 2021
View articletitled, Oncogenic KRAS Recruits an Expansive Transcriptional Network through Mutant p53 to Drive Pancreatic Cancer Metastasis
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Includes: Supplementary data
Journal Articles

BI-3406, a Potent and Selective SOS1–KRAS Interaction Inhibitor, Is Effective in KRAS-Driven Cancers through Combined MEK Inhibition

Free
Marco H. Hofmann, Michael Gmachl, Juergen Ramharter, Fabio Savarese, Daniel Gerlach, Joseph R. Marszalek, Michael P. Sanderson, Dirk Kessler, Francesca Trapani, Heribert Arnhof, Klaus Rumpel, Dana-Adriana Botesteanu, Peter Ettmayer, Thomas Gerstberger, Christiane Kofink, Tobias Wunberg, Andreas Zoephel, Szu-Chin Fu, Jessica L. Teh, Jark Böttcher, Nikolai Pototschnig, Franziska Schachinger, Katharina Schipany, Simone Lieb, Christopher P. Vellano, Jonathan C. O'Connell, Rachel L. Mendes, Jurgen Moll, Mark Petronczki, Timothy P. Heffernan, Mark Pearson, Darryl B. McConnell, Norbert Kraut
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2021) 11 (1): 142–157.
https://doi.org/10.1158/2159-8290.CD-20-0142
Published: 06 January 2021
View articletitled, BI-3406, a Potent and Selective SOS1–KRAS Interaction Inhibitor, Is Effective in KRAS-Driven Cancers through Combined MEK Inhibition
Open the PDF for BI-3406, a Potent and Selective SOS1–KRAS Interaction Inhibitor, Is Effective in KRAS-Driven Cancers through Combined MEK Inhibition in another window
Includes: Supplementary data
Journal Articles

In Vivo Genetic Screens of Patient-Derived Tumors Revealed Unexpected Frailty of the Transformed Phenotype

Free
Daniela Bossi, Angelo Cicalese, Gaetano I. Dellino, Lucilla Luzi, Laura Riva, Carolina D'Alesio, Giuseppe R. Diaferia, Alessandro Carugo, Elena Cavallaro, Rossana Piccioni, Massimo Barberis, Giovanni Mazzarol, Alessandro Testori, Simona Punzi, Isabella Pallavicini, Giulio Tosti, Luciano Giacó, Giorgio Melloni, Timothy P. Heffernan, Gioacchino Natoli, Giulio F. Draetta, Saverio Minucci, PierGiuseppe Pelicci, Luisa Lanfrancone
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2016) 6 (6): 650–663.
https://doi.org/10.1158/2159-8290.CD-15-1200
Published: 02 June 2016
View articletitled, In Vivo Genetic Screens of Patient-Derived Tumors Revealed Unexpected Frailty of the Transformed Phenotype
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Includes: Supplementary data
Journal Articles

Loss of PTEN Promotes Resistance to T Cell–Mediated Immunotherapy

Free
Weiyi Peng, Jie Qing Chen, Chengwen Liu, Shruti Malu, Caitlin Creasy, Michael T. Tetzlaff, Chunyu Xu, Jodi A. McKenzie, Chunlei Zhang, Xiaoxuan Liang, Leila J. Williams, Wanleng Deng, Guo Chen, Rina Mbofung, Alexander J. Lazar, Carlos A. Torres-Cabala, Zachary A. Cooper, Pei-Ling Chen, Trang N. Tieu, Stefani Spranger, Xiaoxing Yu, Chantale Bernatchez, Marie-Andree Forget, Cara Haymaker, Rodabe Amaria, Jennifer L. McQuade, Isabella C. Glitza, Tina Cascone, Haiyan S. Li, Lawrence N. Kwong, Timothy P. Heffernan, Jianhua Hu, Roland L. Bassett, Jr, Marcus W. Bosenberg, Scott E. Woodman, Willem W. Overwijk, Gregory Lizée, Jason Roszik, Thomas F. Gajewski, Jennifer A. Wargo, Jeffrey E. Gershenwald, Laszlo Radvanyi, Michael A. Davies, Patrick Hwu
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2016) 6 (2): 202–216.
https://doi.org/10.1158/2159-8290.CD-15-0283
Published: 04 February 2016
View articletitled, Loss of PTEN Promotes Resistance to T Cell–Mediated Immunotherapy
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Includes: Supplementary data
Journal Articles

Dual Roles of RNF2 in Melanoma Progression

Free
Kunal Rai, Kadir C. Akdemir, Lawrence N. Kwong, Petko Fiziev, Chang-Jiun Wu, Emily Z. Keung, Sneha Sharma, Neha S. Samant, Maura Williams, Jacob B. Axelrad, Amiksha Shah, Dong Yang, Elizabeth A. Grimm, Michelle C. Barton, Denai R. Milton, Timothy P. Heffernan, James W. Horner, Suhendan Ekmekcioglu, Alexander J. Lazar, Jason Ernst, Lynda Chin
Journal: Cancer Discovery
Cancer Discov (2015) 5 (12): 1314–1327.
https://doi.org/10.1158/2159-8290.CD-15-0493
Published: 03 December 2015
View articletitled, Dual Roles of RNF2 in Melanoma Progression
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Includes: Supplementary data
Journal Articles

Co-occurring Genomic Alterations Define Major Subsets of KRAS-Mutant Lung Adenocarcinoma with Distinct Biology, Immune Profiles, and Therapeutic Vulnerabilities

Free
Ferdinandos Skoulidis, Lauren A. Byers, Lixia Diao, Vassiliki A. Papadimitrakopoulou, Pan Tong, Julie Izzo, Carmen Behrens, Humam Kadara, Edwin R. Parra, Jaime Rodriguez Canales, Jianjun Zhang, Uma Giri, Jayanthi Gudikote, Maria A. Cortez, Chao Yang, Youhong Fan, Michael Peyton, Luc Girard, Kevin R. Coombes, Carlo Toniatti, Timothy P. Heffernan, Murim Choi, Garrett M. Frampton, Vincent Miller, John N. Weinstein, Roy S. Herbst, Kwok-Kin Wong, Jianhua Zhang, Padmanee Sharma, Gordon B. Mills, Waun K. Hong, John D. Minna, James P. Allison, Andrew Futreal, Jing Wang, Ignacio I. Wistuba, John V. Heymach
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2015) 5 (8): 860–877.
https://doi.org/10.1158/2159-8290.CD-14-1236
Published: 03 August 2015
View articletitled, Co-occurring Genomic Alterations Define Major Subsets of KRAS-Mutant Lung Adenocarcinoma with Distinct Biology, Immune Profiles, and Therapeutic Vulnerabilities
Open the PDF for Co-occurring Genomic Alterations Define Major Subsets of KRAS-Mutant Lung Adenocarcinoma with Distinct Biology, Immune Profiles, and Therapeutic Vulnerabilities in another window
Includes: Supplementary data
Journal Articles

A Systems Biology Approach to Personalizing Therapeutic Combinations

Free
Lawrence N. Kwong, Timothy P. Heffernan, Lynda Chin
Journal: Cancer Discovery
Cancer Discov (2013) 3 (12): 1339–1344.
https://doi.org/10.1158/2159-8290.CD-13-0394
Published: 10 December 2013
View articletitled, A Systems Biology Approach to Personalizing Therapeutic Combinations
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