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Timothy A. Yap
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Journal Articles

BRCA1-Mediated Dual Regulation of Ferroptosis Exposes a Vulnerability to GPX4 and PARP Co-Inhibition in BRCA1-Deficient Cancers

Guang Lei, Chao Mao, Amber D. Horbath, Yuelong Yan, Shirong Cai, Jun Yao, Yan Jiang, Mingchuang Sun, Xiaoguang Liu, Jun Cheng, Zhihao Xu, Hyemin Lee, Qidong Li, Zhengze Lu, Li Zhuang, Mei-Kuang Chen, Anagha Alapati, Timothy A. Yap, Mien-Chie Hung, Mingjian James You, Helen Piwnica-Worms, Boyi Gan
Journal: Cancer Discovery
Cancer Discov (2024) 14 (8): 1476–1495.
https://doi.org/10.1158/2159-8290.CD-23-1220
Published: 02 August 2024
View article titled, BRCA1-Mediated Dual Regulation of Ferroptosis Exposes a Vulnerability to GPX4 and PARP Co-Inhibition in <em>BRCA1</em>-Deficient Cancers
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Includes: Supplementary data
Journal Articles

SHP2 Inhibition Sensitizes Diverse Oncogene-Addicted Solid Tumors to Re-treatment with Targeted Therapy

Alexander Drilon, Manish R. Sharma, Melissa L. Johnson, Timothy A. Yap, Shirish Gadgeel, Dale Nepert, Gang Feng, Micaela B. Reddy, Allison S. Harney, Mohamed Elsayed, Adam W. Cook, Christina E. Wong, Ronald J. Hinklin, Yutong Jiang, Eric N. Brown, Nickolas A. Neitzel, Ellen R. Laird, Wen-I Wu, Anurag Singh, Ping Wei, Keith A. Ching, John J. Gaudino, Patrice A. Lee, Dylan P. Hartley, S. Michael Rothenberg
Journal: Cancer Discovery
Cancer Discov (2023) 13 (8): 1789–1801.
https://doi.org/10.1158/2159-8290.CD-23-0361
Published: 04 August 2023
View article titled, SHP2 Inhibition Sensitizes Diverse Oncogene-Addicted Solid Tumors to Re-treatment with Targeted Therapy
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Includes: Supplementary data
Journal Articles

Precision Combination Therapies Based on Recurrent Oncogenic Coalterations

Xubin Li, Elisabeth K. Dowling, Gonghong Yan, Zeynep Dereli, Behnaz Bozorgui, Parisa Imanirad, Jacob H. Elnaggar, Augustin Luna, David G. Menter, Patrick G. Pilié, Timothy A. Yap, Scott Kopetz, Chris Sander, Anil Korkut
Journal: Cancer Discovery
Cancer Discov (2022) 12 (6): 1542–1559.
https://doi.org/10.1158/2159-8290.CD-21-0832
Published: 02 June 2022
View article titled, Precision Combination Therapies Based on Recurrent Oncogenic Coalterations
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Includes: Supplementary data
Journal Articles

Development of Immunotherapy Combination Strategies in Cancer

Timothy A. Yap, Eileen E. Parkes, Weiyi Peng, Justin T. Moyers, Michael A. Curran, Hussein A. Tawbi
Journal: Cancer Discovery
Cancer Discov (2021) 11 (6): 1368–1397.
https://doi.org/10.1158/2159-8290.CD-20-1209
Published: 01 June 2021
View article titled, Development of Immunotherapy Combination Strategies in Cancer
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Journal Articles

First-in-Human Trial of the Oral Ataxia Telangiectasia and RAD3-Related (ATR) Inhibitor BAY 1895344 in Patients with Advanced Solid Tumors

Timothy A. Yap, David S.P. Tan, Angelika Terbuch, Reece Caldwell, Christina Guo, Boon Cher Goh, Valerie Heong, Noor R. Md. Haris, Saira Bashir, Yvette Drew, David S. Hong, Funda Meric-Bernstam, Gary Wilkinson, Joseph Hreiki, Antje M. Wengner, Friedhelm Bladt, Andreas Schlicker, Matthias Ludwig, Yinghui Zhou, Li Liu, Sonal Bordia, Ruth Plummer, Eleni Lagkadinou, Johann S. de Bono
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2021) 11 (1): 80–91.
https://doi.org/10.1158/2159-8290.CD-20-0868
Published: 06 January 2021
View article titled, First-in-Human Trial of the Oral Ataxia Telangiectasia and RAD3-Related (ATR) Inhibitor BAY 1895344 in Patients with Advanced Solid Tumors
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Includes: Supplementary data
Journal Articles

Triplet Therapy with Palbociclib, Taselisib, and Fulvestrant in PIK3CA-Mutant Breast Cancer and Doublet Palbociclib and Taselisib in Pathway-Mutant Solid Cancers

Javier Pascual, Joline S.J. Lim, Iain R. Macpherson, Anne C. Armstrong, Alistair Ring, Alicia F.C. Okines, Rosalind J. Cutts, Maria Teresa Herrera-Abreu, Isaac Garcia-Murillas, Alex Pearson, Sarah Hrebien, Heidrun Gevensleben, Paula Z. Proszek, Michael Hubank, Margaret Hills, Jenny King, Mona Parmar, Toby Prout, Laura Finneran, Jason Malia, Karen E. Swales, Ruth Ruddle, Florence I. Raynaud, Alison Turner, Emma Hall, Timothy A. Yap, Juanita S. Lopez, Nicholas C. Turner
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2021) 11 (1): 92–107.
https://doi.org/10.1158/2159-8290.CD-20-0553
Published: 06 January 2021
View article titled, Triplet Therapy with Palbociclib, Taselisib, and Fulvestrant in <em>PIK3CA</em>-Mutant Breast Cancer and Doublet Palbociclib and Taselisib in Pathway-Mutant Solid Cancers
Open the PDF for Triplet Therapy with Palbociclib, Taselisib, and Fulvestrant in <em>PIK3CA</em>-Mutant Breast Cancer and Doublet Palbociclib and Taselisib in Pathway-Mutant Solid Cancers in another window
Includes: Supplementary data
Journal Articles

Phase I Trial of the PARP Inhibitor Olaparib and AKT Inhibitor Capivasertib in Patients with BRCA1/2- and Non–BRCA1/2-Mutant Cancers

Timothy A. Yap, Rebecca Kristeleit, Vasiliki Michalarea, Stephen J. Pettitt, Joline S.J. Lim, Suzanne Carreira, Desamparados Roda, Rowan Miller, Ruth Riisnaes, Susana Miranda, Ines Figueiredo, Daniel Nava Rodrigues, Sarah Ward, Ruth Matthews, Mona Parmar, Alison Turner, Nina Tunariu, Neha Chopra, Heidrun Gevensleben, Nicholas C. Turner, Ruth Ruddle, Florence I. Raynaud, Shaun Decordova, Karen E. Swales, Laura Finneran, Emma Hall, Paul Rugman, Justin P.O. Lindemann, Andrew Foxley, Christopher J. Lord, Udai Banerji, Ruth Plummer, Bristi Basu, Juanita S. Lopez, Yvette Drew, Johann S. de Bono
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2020) 10 (10): 1528–1543.
https://doi.org/10.1158/2159-8290.CD-20-0163
Published: 01 October 2020
View article titled, Phase I Trial of the PARP Inhibitor Olaparib and AKT Inhibitor Capivasertib in Patients with <em>BRCA1/2</em>- and Non–<em>BRCA1/2</em>-Mutant Cancers
Open the PDF for Phase I Trial of the PARP Inhibitor Olaparib and AKT Inhibitor Capivasertib in Patients with <em>BRCA1/2</em>- and Non–<em>BRCA1/2</em>-Mutant Cancers in another window
Includes: Supplementary data
Journal Articles

Clinical BRCA1/2 Reversion Analysis Identifies Hotspot Mutations and Predicted Neoantigens Associated with Therapy Resistance

Stephen J. Pettitt, Jessica R. Frankum, Marco Punta, Stefano Lise, John Alexander, Yi Chen, Timothy A. Yap, Syed Haider, Andrew N.J. Tutt, Christopher J. Lord
Journal: Cancer Discovery
Cancer Discov (2020) 10 (10): 1475–1488.
https://doi.org/10.1158/2159-8290.CD-19-1485
Published: 01 October 2020
View article titled, Clinical <em>BRCA1/2</em> Reversion Analysis Identifies Hotspot Mutations and Predicted Neoantigens Associated with Therapy Resistance
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Includes: Supplementary data
Journal Articles

Targeting BRAF-Mutant Colorectal Cancer: Progress in Combination Strategies

Raghav Sundar, David S. Hong, Scott Kopetz, Timothy A. Yap
Journal: Cancer Discovery
Cancer Discov (2017) 7 (6): 558–560.
https://doi.org/10.1158/2159-8290.CD-17-0087
Published: 01 June 2017
View article titled, Targeting <em>BRAF</em>-Mutant Colorectal Cancer: Progress in Combination Strategies
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Journal Articles

Targeting DNA Repair in Cancer: Beyond PARP Inhibitors

Jessica S. Brown, Brent O'Carrigan, Stephen P. Jackson, Timothy A. Yap
Journal: Cancer Discovery
Cancer Discov (2017) 7 (1): 20–37.
https://doi.org/10.1158/2159-8290.CD-16-0860
Published: 05 January 2017
View article titled, Targeting DNA Repair in Cancer: Beyond PARP Inhibitors
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Journal Articles

CDK4/6 Inhibitors: Promising Opportunities beyond Breast Cancer

Joline S.J. Lim, Nicholas C. Turner, Timothy A. Yap
Journal: Cancer Discovery
Cancer Discov (2016) 6 (7): 697–699.
https://doi.org/10.1158/2159-8290.CD-16-0563
Published: 30 June 2016
View article titled, CDK4/6 Inhibitors: Promising Opportunities beyond Breast Cancer
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