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Stephen C. Mack
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Journal Articles

ZFTA–RELA Dictates Oncogenic Transcriptional Programs to Drive Aggressive Supratentorial Ependymoma

Amir Arabzade, Yanhua Zhao, Srinidhi Varadharajan, Hsiao-Chi Chen, Selin Jessa, Bryan Rivas, Austin J. Stuckert, Minerva Solis, Alisha Kardian, Dana Tlais, Brian J. Golbourn, Ann-Catherine J. Stanton, Yuen San Chan, Calla Olson, Kristen L. Karlin, Kathleen Kong, Robert Kupp, Baoli Hu, Sarah G. Injac, Madeline Ngo, Peter R. Wang, Luz A. De León, Felix Sahm, Daisuke Kawauchi, Stefan M. Pfister, Charles Y. Lin, H. Courtney Hodges, Irtisha Singh, Thomas F. Westbrook, Murali M. Chintagumpala, Susan M. Blaney, Donald W. Parsons, Kristian W. Pajtler, Sameer Agnihotri, Richard J. Gilbertson, Joanna Yi, Nada Jabado, Claudia L. Kleinman, Kelsey C. Bertrand, Benjamin Deneen, Stephen C. Mack
Journal: Cancer Discovery
Cancer Discov (2021) 11 (9): 2200–2215.
https://doi.org/10.1158/2159-8290.CD-20-1066
Published: 01 September 2021
View article titled, ZFTA–RELA Dictates Oncogenic Transcriptional Programs to Drive Aggressive Supratentorial Ependymoma
Open the PDF for ZFTA–RELA Dictates Oncogenic Transcriptional Programs to Drive Aggressive Supratentorial Ependymoma in another window
Includes: Supplementary data
Journal Articles

Cross-Species Genomics Reveals Oncogenic Dependencies in ZFTA/C11orf95 Fusion–Positive Supratentorial Ependymomas

Tuyu Zheng, David R. Ghasemi, Konstantin Okonechnikov, Andrey Korshunov, Martin Sill, Kendra K. Maass, Patricia Benites Goncalves da Silva, Marina Ryzhova, Johannes Gojo, Damian Stichel, Amir Arabzade, Robert Kupp, Julia Benzel, Shinichiro Taya, Toma Adachi, Ryo Shiraishi, Nicolas U. Gerber, Dominik Sturm, Jonas Ecker, Philipp Sievers, Florian Selt, Rebecca Chapman, Christine Haberler, Dominique Figarella-Branger, Guido Reifenberger, Gudrun Fleischhack, Stefan Rutkowski, Andrew M. Donson, Vijay Ramaswamy, David Capper, David W. Ellison, Christel C. Herold-Mende, Ulrich Schüller, Sebastian Brandner, Pablo Hernáiz Driever, Johan M. Kros, Matija Snuderl, Till Milde, Richard G. Grundy, Mikio Hoshino, Stephen C. Mack, Richard J. Gilbertson, David T.W. Jones, Marcel Kool, Andreas von Deimling, Stefan M. Pfister, Felix Sahm, Daisuke Kawauchi, Kristian W. Pajtler
Journal: Cancer Discovery
Cancer Discov (2021) 11 (9): 2230–2247.
https://doi.org/10.1158/2159-8290.CD-20-0963
Published: 01 September 2021
View article titled, Cross-Species Genomics Reveals Oncogenic Dependencies in ZFTA/C11orf95 Fusion–Positive Supratentorial Ependymomas
Open the PDF for Cross-Species Genomics Reveals Oncogenic Dependencies in ZFTA/C11orf95 Fusion–Positive Supratentorial Ependymomas in another window
Includes: Supplementary data
Journal Articles

ZFTA Translocations Constitute Ependymoma Chromatin Remodeling and Transcription Factors

Robert Kupp, Lisa Ruff, Sabrina Terranova, Erica Nathan, Stephane Ballereau, Rory Stark, Chandra Sekhar Reddy Chilamakuri, Nadin Hoffmann, Katherine Wickham-Rahrmann, Marcus Widdess, Amir Arabzade, Yanhua Zhao, Srinidhi Varadharajan, Tuyu Zheng, Mohankumar Murugesan, Stefan M. Pfister, Daisuke Kawauchi, Kristian W. Pajtler, Benjamin Deneen, Stephen C. Mack, Katherine E. Masih, Berkley E. Gryder, Javed Khan, Richard J. Gilbertson
Journal: Cancer Discovery
Cancer Discov (2021) 11 (9): 2216–2229.
https://doi.org/10.1158/2159-8290.CD-20-1052
Published: 01 September 2021
View article titled, <em>ZFTA</em> Translocations Constitute Ependymoma Chromatin Remodeling and Transcription Factors
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Includes: Supplementary data
Journal Articles

H3.3 G34W Promotes Growth and Impedes Differentiation of Osteoblast-Like Mesenchymal Progenitors in Giant Cell Tumor of Bone

Sima Khazaei, Nicolas De Jay, Shriya Deshmukh, Liam D. Hendrikse, Wajih Jawhar, Carol C.L. Chen, Leonie G. Mikael, Damien Faury, Dylan M. Marchione, Joel Lanoix, Éric Bonneil, Takeaki Ishii, Siddhant U. Jain, Kateryna Rossokhata, Tianna S. Sihota, Robert Eveleigh, Véronique Lisi, Ashot S. Harutyunyan, Sungmi Jung, Jason Karamchandani, Brendan C. Dickson, Robert Turcotte, Jay S. Wunder, Pierre Thibault, Peter W. Lewis, Benjamin A. Garcia, Stephen C. Mack, Michael D. Taylor, Livia Garzia, Claudia L. Kleinman, Nada Jabado
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2020) 10 (12): 1968–1987.
https://doi.org/10.1158/2159-8290.CD-20-0461
Published: 01 December 2020
View article titled, H3.3 G34W Promotes Growth and Impedes Differentiation of Osteoblast-Like Mesenchymal Progenitors in Giant Cell Tumor of Bone
Open the PDF for H3.3 G34W Promotes Growth and Impedes Differentiation of Osteoblast-Like Mesenchymal Progenitors in Giant Cell Tumor of Bone in another window
Includes: Supplementary data
Journal Articles

The Meningioma Enhancer Landscape Delineates Novel Subgroups and Drives Druggable Dependencies

Briana C. Prager, Harish N. Vasudevan, Deobrat Dixit, Jean A. Bernatchez, Qiulian Wu, Lisa C. Wallace, Shruti Bhargava, Derrick Lee, Bradley H. King, Andrew R. Morton, Ryan C. Gimple, Melike Pekmezci, Zhe Zhu, Jair L. Siqueira-Neto, Xiuxing Wang, Qi Xie, Clark Chen, Gene H. Barnett, Michael A. Vogelbaum, Stephen C. Mack, Lukas Chavez, Arie Perry, David R. Raleigh, Jeremy N. Rich
Journal: Cancer Discovery
Cancer Discov (2020) 10 (11): 1722–1741.
https://doi.org/10.1158/2159-8290.CD-20-0160
Published: 02 November 2020
View article titled, The Meningioma Enhancer Landscape Delineates Novel Subgroups and Drives Druggable Dependencies
Open the PDF for The Meningioma Enhancer Landscape Delineates Novel Subgroups and Drives Druggable Dependencies in another window
Includes: Supplementary data
Journal Articles

Targeting Glioblastoma Stem Cells through Disruption of the Circadian Clock

Zhen Dong, Guoxin Zhang, Meng Qu, Ryan C. Gimple, Qiulian Wu, Zhixin Qiu, Briana C. Prager, Xiuxing Wang, Leo J.Y. Kim, Andrew R. Morton, Deobrat Dixit, Wenchao Zhou, Haidong Huang, Bin Li, Zhe Zhu, Shideng Bao, Stephen C. Mack, Lukas Chavez, Steve A. Kay, Jeremy N. Rich
Journal: Cancer Discovery
Cancer Discov (2019) 9 (11): 1556–1573.
https://doi.org/10.1158/2159-8290.CD-19-0215
Published: 01 November 2019
View article titled, Targeting Glioblastoma Stem Cells through Disruption of the Circadian Clock
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Includes: Supplementary data
Journal Articles

Glioma Stem Cell–Specific Superenhancer Promotes Polyunsaturated Fatty-Acid Synthesis to Support EGFR Signaling

Ryan C. Gimple, Reilly L. Kidwell, Leo J.Y. Kim, Tengqian Sun, Anthony D. Gromovsky, Qiulian Wu, Megan Wolf, Deguan Lv, Shruti Bhargava, Li Jiang, Briana C. Prager, Xiuxing Wang, Qing Ye, Zhe Zhu, Guoxin Zhang, Zhen Dong, Linjie Zhao, Derrick Lee, Junfeng Bi, Andrew E. Sloan, Paul S. Mischel, J. Mark Brown, Hu Cang, Tao Huan, Stephen C. Mack, Qi Xie, Jeremy N. Rich
Journal: Cancer Discovery
Cancer Discov (2019) 9 (9): 1248–1267.
https://doi.org/10.1158/2159-8290.CD-19-0061
Published: 03 September 2019
View article titled, Glioma Stem Cell–Specific Superenhancer Promotes Polyunsaturated Fatty-Acid Synthesis to Support EGFR Signaling
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Includes: Supplementary data
Journal Articles

“PEAR-ing” Genomic and Epigenomic Analyses for Cancer Gene Discovery

Stephen C. Mack, Jeremy N. Rich, Peter C. Scacheri
Journal: Cancer Discovery
Cancer Discov (2015) 5 (10): 1018–1020.
https://doi.org/10.1158/2159-8290.CD-15-0985
Published: 30 September 2015
View article titled, “PEAR-ing” Genomic and Epigenomic Analyses for Cancer Gene Discovery
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