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Sheng F. Cai
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Journal Articles

CRISPR Dependency Screens in Primary Hematopoietic Stem Cells Identify KDM3B as a Genotype-specific Vulnerability in IDH2- and TET2-mutant Cells

Michael R. Waarts, Shoron Mowla, Meaghan Boileau, Anthony R. Martinez Benitez, Junya Sango, Maya Bagish, Inés Fernández-Maestre, Yufan Shan, Shira E. Eisman, Young C. Park, Matthew Wereski, Isabelle Csete, Kavi O’Connor, Angelica C. Romero-Vega, Linde A. Miles, Wenbin Xiao, Xiaodi Wu, Richard P. Koche, Scott A. Armstrong, Alan H. Shih, Eirini P. Papapetrou, Jason M. Butler, Sheng F. Cai, Robert L. Bowman, Ross L. Levine
Journal: Cancer Discovery
Cancer Discov (2024) 14 (10): 1860–1878.
https://doi.org/10.1158/2159-8290.CD-23-1092
Published: 04 October 2024
View article titled, CRISPR Dependency Screens in Primary Hematopoietic Stem Cells Identify <em>KDM3B</em> as a Genotype-specific Vulnerability in <em>IDH2</em>- and <em>TET2</em>-mutant Cells
Open the PDF for CRISPR Dependency Screens in Primary Hematopoietic Stem Cells Identify <em>KDM3B</em> as a Genotype-specific Vulnerability in <em>IDH2</em>- and <em>TET2</em>-mutant Cells in another window
Includes: Supplementary data
Journal Articles

Jak2V617F Reversible Activation Shows Its Essential Requirement in Myeloproliferative Neoplasms

Andrew J. Dunbar, Robert L. Bowman, Young C. Park, Kavi O'Connor, Franco Izzo, Robert M. Myers, Abdul Karzai, Zachary Zaroogian, Won Jun Kim, Inés Fernández-Maestre, Michael R. Waarts, Abbas Nazir, Wenbin Xiao, Tamara Codilupi, Max Brodsky, Mirko Farina, Louise Cai, Sheng F. Cai, Benjamin Wang, Wenbin An, Julie L. Yang, Shoron Mowla, Shira E. Eisman, Amritha Varshini Hanasoge Somasundara, Jacob L. Glass, Tanmay Mishra, Remie Houston, Emily Guzzardi, Anthony R. Martinez Benitez, Aaron D. Viny, Richard P. Koche, Sara C. Meyer, Dan A. Landau, Ross L. Levine
Journal: Cancer Discovery
Cancer Discov (2024) 14 (5): 737–751.
https://doi.org/10.1158/2159-8290.CD-22-0952
Published: 01 May 2024
View article titled, Jak2<sup>V617F</sup> Reversible Activation Shows Its Essential Requirement in Myeloproliferative Neoplasms
Open the PDF for Jak2<sup>V617F</sup> Reversible Activation Shows Its Essential Requirement in Myeloproliferative Neoplasms in another window
Includes: Supplementary data
Journal Articles

Disabling Uncompetitive Inhibition of Oncogenic IDH Mutations Drives Acquired Resistance

Junhua Lyu, Yuxuan Liu, Lihu Gong, Mingyi Chen, Yazan F. Madanat, Yuannyu Zhang, Feng Cai, Zhimin Gu, Hui Cao, Pranita Kaphle, Yoon Jung Kim, Fatma N. Kalkan, Helen Stephens, Kathryn E. Dickerson, Min Ni, Weina Chen, Prapti Patel, Alice S. Mims, Uma Borate, Amy Burd, Sheng F. Cai, C. Cameron Yin, M. James You, Stephen S. Chung, Robert H. Collins, Ralph J. DeBerardinis, Xin Liu, Jian Xu
Journal: Cancer Discovery
Cancer Discov (2023) 13 (1): 170–193.
https://doi.org/10.1158/2159-8290.CD-21-1661
Published: 09 January 2023
View article titled, Disabling Uncompetitive Inhibition of Oncogenic IDH Mutations Drives Acquired Resistance
Open the PDF for Disabling Uncompetitive Inhibition of Oncogenic IDH Mutations Drives Acquired Resistance in another window
Includes: Supplementary data
Journal Articles

Leukemia Cell of Origin Influences Apoptotic Priming and Sensitivity to LSD1 Inhibition

Sheng F. Cai, S. Haihua Chu, Aaron D. Goldberg, Salma Parvin, Richard P. Koche, Jacob L. Glass, Eytan M. Stein, Martin S. Tallman, Filiz Sen, Christopher A. Famulare, Monica Cusan, Chun-Hao Huang, Chun-Wei Chen, Lihua Zou, Keith B. Cordner, Nicole L. DelGaudio, Vidushi Durani, Mitali Kini, Madison Rex, Helen S. Tian, Johannes Zuber, Timour Baslan, Scott W. Lowe, Hugh Y. Rienhoff, Jr, Anthony Letai, Ross L. Levine, Scott A. Armstrong
Journal: Cancer Discovery
Cancer Discov (2020) 10 (10): 1500–1513.
https://doi.org/10.1158/2159-8290.CD-19-1469
Published: 01 October 2020
View article titled, Leukemia Cell of Origin Influences Apoptotic Priming and Sensitivity to LSD1 Inhibition
Open the PDF for Leukemia Cell of Origin Influences Apoptotic Priming and Sensitivity to LSD1 Inhibition in another window
Includes: Supplementary data