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Samuel J. Klempner
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Journal Articles

Efficacy and Safety of Adagrasib plus Cetuximab in Patients with KRASG12C-Mutated Metastatic Colorectal Cancer

Rona Yaeger, Nataliya V. Uboha, Meredith S. Pelster, Tanios S. Bekaii-Saab, Minal Barve, Joel Saltzman, Joshua K. Sabari, Julio A. Peguero, Andrew Scott Paulson, Pasi A. Jänne, Marcia Cruz-Correa, Kenna Anderes, Karen Velastegui, Xiaohong Yan, Hirak Der-Torossian, Samuel J. Klempner, Scott E. Kopetz
Journal: Cancer Discovery
Cancer Discov (2024) 14 (6): 982–993.
https://doi.org/10.1158/2159-8290.CD-24-0217
Published: 03 June 2024
View articletitled, Efficacy and Safety of Adagrasib plus Cetuximab in Patients with KRASG12C-Mutated Metastatic Colorectal Cancer
Open the PDF for Efficacy and Safety of Adagrasib plus Cetuximab in Patients with KRASG12C-Mutated Metastatic Colorectal Cancer in another window
Includes: Supplementary data
Journal Articles

Early Immune Remodeling Steers Clinical Response to First-Line Chemoimmunotherapy in Advanced Gastric Cancer

Minae An, Arnav Mehta, Byung Hoon Min, You Jeong Heo, Samuel J. Wright, Milan Parikh, Lynn Bi, Hyuk Lee, Tae Jun Kim, Song-Yi Lee, Jeonghyeon Moon, Ryan J. Park, Matthew R. Strickland, Woong-Yang Park, Won Ki Kang, Kyoung-Mee Kim, Seung Tae Kim, Samuel J. Klempner, Jeeyun Lee
Journal: Cancer Discovery
Cancer Discov (2024) 14 (5): 766–785.
https://doi.org/10.1158/2159-8290.CD-23-0857
Published: 01 May 2024
View articletitled, Early Immune Remodeling Steers Clinical Response to First-Line Chemoimmunotherapy in Advanced Gastric Cancer
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Includes: Supplementary data
Journal Articles

Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker

Martin S. Taylor, Connie Wu, Peter C. Fridy, Stephanie J. Zhang, Yasmeen Senussi, Justina C. Wolters, Tatiana Cajuso, Wen-Chih Cheng, John D. Heaps, Bryant D. Miller, Kei Mori, Limor Cohen, Hua Jiang, Kelly R. Molloy, Brian T. Chait, Michael G. Goggins, Irun Bhan, Joseph W. Franses, Xiaoyu Yang, Mary-Ellen Taplin, Xinan Wang, David C. Christiani, Bruce E. Johnson, Matthew Meyerson, Ravindra Uppaluri, Ann Marie Egloff, Elyssa N. Denault, Laura M. Spring, Tian-Li Wang, Ie-Ming Shih, Jennifer E. Fairman, Euihye Jung, Kshitij S. Arora, Osman H. Yilmaz, Sonia Cohen, Tatyana Sharova, Gary Chi, Bryanna L. Norden, Yuhui Song, Linda T. Nieman, Leontios Pappas, Aparna R. Parikh, Matthew R. Strickland, Ryan B. Corcoran, Tomas Mustelin, George Eng, Ömer H. Yilmaz, Ursula A. Matulonis, Andrew T. Chan, Steven J. Skates, Bo R. Rueda, Ronny Drapkin, Samuel J. Klempner, Vikram Deshpande, David T. Ting, Michael P. Rout, John LaCava, David R. Walt, Kathleen H. Burns
Journal: Cancer Discovery
Cancer Discov (2023) 13 (12): 2532–2547.
https://doi.org/10.1158/2159-8290.CD-23-0313
Published: 12 December 2023
View articletitled, Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker
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Includes: Supplementary data
Journal Articles

The Genomics of Colorectal Cancer in Populations with African and European Ancestry

Parvathi A. Myer, Jessica K. Lee, Russell W. Madison, Kith Pradhan, Justin Y. Newberg, Carmen R. Isasi, Samuel J. Klempner, Garrett M. Frampton, Jeffery S. Ross, Jeffrey M. Venstrom, Alexa B. Schrock, Sudipto Das, Leonard Augenlicht, Amit Verma, John M. Greally, Srilakshmi M. Raj, Sanjay Goel, Siraj M. Ali
Journal: Cancer Discovery
Cancer Discov (2022) 12 (5): 1282–1293.
https://doi.org/10.1158/2159-8290.CD-21-0813
Published: 02 May 2022
View articletitled, The Genomics of Colorectal Cancer in Populations with African and European Ancestry
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Includes: Supplementary data
Journal Articles

Early Tumor–Immune Microenvironmental Remodeling and Response to First-Line Fluoropyrimidine and Platinum Chemotherapy in Advanced Gastric Cancer

Ryul Kim, Minae An, Hyuk Lee, Arnav Mehta, You Jeong Heo, Kyoung-Mee Kim, Song-Yi Lee, Jeonghyeon Moon, Seung Tae Kim, Byung-Hoon Min, Tae Jun Kim, Sun Young Rha, Won Ki Kang, Woong-Yang Park, Samuel J. Klempner, Jeeyun Lee
Journal: Cancer Discovery
Cancer Discov (2022) 12 (4): 984–1001.
https://doi.org/10.1158/2159-8290.CD-21-0888
Published: 01 April 2022
View articletitled, Early Tumor–Immune Microenvironmental Remodeling and Response to First-Line Fluoropyrimidine and Platinum Chemotherapy in Advanced Gastric Cancer
Open the PDF for Early Tumor–Immune Microenvironmental Remodeling and Response to First-Line Fluoropyrimidine and Platinum Chemotherapy in Advanced Gastric Cancer in another window
Includes: Supplementary data
Journal Articles

Are You a TMBeliever? Mutations and Atezolizumab Response in Solid Tumors

Steven B. Maron, Samuel J. Klempner
Journal: Cancer Discovery
Cancer Discov (2022) 12 (3): 602–603.
https://doi.org/10.1158/2159-8290.CD-21-1642
Published: 08 March 2022
View articletitled, Are You a TMBeliever? Mutations and Atezolizumab Response in Solid Tumors
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Journal Articles

Determinants of Response and Intrinsic Resistance to PD-1 Blockade in Microsatellite Instability–High Gastric Cancer

Minsuk Kwon, Minae An, Samuel J. Klempner, Hyuk Lee, Kyoung-Mee Kim, Jason K. Sa, Hee Jin Cho, Jung Yong Hong, Taehyang Lee, Yang Won Min, Tae Jun Kim, Byung-Hoon Min, Woong-Yang Park, Won Ki Kang, Kyu-Tae Kim, Seung Tae Kim, Jeeyun Lee
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2021) 11 (9): 2168–2185.
https://doi.org/10.1158/2159-8290.CD-21-0219
Published: 01 September 2021
View articletitled, Determinants of Response and Intrinsic Resistance to PD-1 Blockade in Microsatellite Instability–High Gastric Cancer
Open the PDF for Determinants of Response and Intrinsic Resistance to PD-1 Blockade in Microsatellite Instability–High Gastric Cancer in another window
Includes: Supplementary data
Journal Articles

Clinical Acquired Resistance to KRASG12C Inhibition through a Novel KRAS Switch-II Pocket Mutation and Polyclonal Alterations Converging on RAS–MAPK Reactivation

Noritaka Tanaka, Jessica J. Lin, Chendi Li, Meagan B. Ryan, Junbing Zhang, Lesli A. Kiedrowski, Alexa G. Michel, Mohammed U. Syed, Katerina A. Fella, Mustafa Sakhi, Islam Baiev, Dejan Juric, Justin F. Gainor, Samuel J. Klempner, Jochen K. Lennerz, Giulia Siravegna, Liron Bar-Peled, Aaron N. Hata, Rebecca S. Heist, Ryan B. Corcoran
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2021) 11 (8): 1913–1922.
https://doi.org/10.1158/2159-8290.CD-21-0365
Published: 01 August 2021
View articletitled, Clinical Acquired Resistance to KRASG12C Inhibition through a Novel KRAS Switch-II Pocket Mutation and Polyclonal Alterations Converging on RAS–MAPK Reactivation
Open the PDF for Clinical Acquired Resistance to KRASG12C Inhibition through a Novel KRAS Switch-II Pocket Mutation and Polyclonal Alterations Converging on RAS–MAPK Reactivation in another window
Includes: Supplementary data
Journal Articles

Can the Help Match the Hype? KRASG12C-Specific Inhibitors and Beyond

Samuel J. Klempner, Aaron N. Hata
Journal: Cancer Discovery
Cancer Discov (2020) 10 (1): 20–22.
https://doi.org/10.1158/2159-8290.CD-19-1255
Published: 09 January 2020
View articletitled, Can the Help Match the Hype? KRASG12C-Specific Inhibitors and Beyond
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Journal Articles

Variety Is the Spice of Life, but Maybe Not in Gastroesophageal Adenocarcinomas

Samuel J. Klempner, Daniel V.T. Catenacci
Journal: Cancer Discovery
Cancer Discov (2019) 9 (2): 166–168.
https://doi.org/10.1158/2159-8290.CD-18-1447
Published: 08 February 2019
View articletitled, Variety Is the Spice of Life, but Maybe Not in Gastroesophageal Adenocarcinomas
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Journal Articles

BRAFV600E Mutations in High-Grade Colorectal Neuroendocrine Tumors May Predict Responsiveness to BRAF–MEK Combination Therapy

Samuel J. Klempner, Bruce Gershenhorn, Phu Tran, Thomas K. Lee, Mark G. Erlander, Kyle Gowen, Alexa B. Schrock, Deborah Morosini, Jeffrey S. Ross, Vincent A. Miller, Philip J. Stephens, Sai-Hong Ignatius Ou, Siraj M. Ali
Journal: Cancer Discovery
Cancer Discov (2016) 6 (6): 594–600.
https://doi.org/10.1158/2159-8290.CD-15-1192
Published: 02 June 2016
View articletitled, BRAFV600E Mutations in High-Grade Colorectal Neuroendocrine Tumors May Predict Responsiveness to BRAF–MEK Combination Therapy
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Journal Articles

What a Tangled Web We Weave: Emerging Resistance Mechanisms to Inhibition of the Phosphoinositide 3-Kinase Pathway

Samuel J. Klempner, Andrea P. Myers, Lewis C. Cantley
Journal: Cancer Discovery
Cancer Discov (2013) 3 (12): 1345–1354.
https://doi.org/10.1158/2159-8290.CD-13-0063
Published: 10 December 2013
View articletitled, What a Tangled Web We Weave: Emerging Resistance Mechanisms to Inhibition of the Phosphoinositide 3-Kinase Pathway
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