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Samuel J. Klempner
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Journal Articles

Ultrasensitive detection of circulating LINE-1 ORF1p as a specific multi-cancer biomarker

Martin S. Taylor, Connie Wu, Peter C. Fridy, Stephanie J. Zhang, Yasmeen Senussi, Justina C. Wolters, Tatiana Cajuso, Wen-Chih Cheng, John D. Heaps, Bryant D. Miller, Kei Mori, Limor Cohen, Hua Jiang, Kelly R. Molloy, Brian T. Chait, Michael G. Goggins, Irun Bhan, Joseph W. Franses, Xiaoyu Yang, Mary-Ellen Taplin, Xinan Wang, David C. Christiani, Bruce E. Johnson, Matthew Meyerson, Ravindra Uppaluri, Ann Marie Egloff, Elyssa N. Denault, Laura M. Spring, Tian-Li Wang, Ie-Ming Shih, Jennifer E. Fairman, Euihye Jung, Kshitij S. Arora, Osman H. Yilmaz, Sonia Cohen, Tatyana Sharova, Gary Chi, Bryanna L. Norden, Yuhui Song, Linda T. Nieman, Leontios Pappas, Aparna R. Parikh, Matthew R. Strickland, Ryan B. Corcoran, Tomas Mustelin, George Eng, Omer H. Yilmaz, Ursula A. Matulonis, Steven J. Skates, Bo R. Rueda, Ronny Drapkin, Samuel J. Klempner, Vikram Deshpande, David T. Ting, Michael P. Rout, John LaCava, David R. Walt, Kathleen H. Burns
Journal: Cancer Discovery
Cancer Discov (2023)
https://doi.org/10.1158/2159-8290.CD-23-0313
Published: 12 September 2023
View article titled, Ultrasensitive detection of circulating LINE-1 ORF1p as a specific multi-cancer biomarker
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Includes: Supplementary data
Journal Articles

The Genomics of Colorectal Cancer in Populations with African and European Ancestry

Parvathi A. Myer, Jessica K. Lee, Russell W. Madison, Kith Pradhan, Justin Y. Newberg, Carmen R. Isasi, Samuel J. Klempner, Garrett M. Frampton, Jeffery S. Ross, Jeffrey M. Venstrom, Alexa B. Schrock, Sudipto Das, Leonard Augenlicht, Amit Verma, John M. Greally, Srilakshmi M. Raj, Sanjay Goel, Siraj M. Ali
Journal: Cancer Discovery
Cancer Discov (2022) 12 (5): 1282–1293.
https://doi.org/10.1158/2159-8290.CD-21-0813
Published: 02 May 2022
View article titled, The Genomics of Colorectal Cancer in Populations with African and European Ancestry
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Includes: Supplementary data
Journal Articles

Early Tumor–Immune Microenvironmental Remodeling and Response to First-Line Fluoropyrimidine and Platinum Chemotherapy in Advanced Gastric Cancer

Ryul Kim, Minae An, Hyuk Lee, Arnav Mehta, You Jeong Heo, Kyoung-Mee Kim, Song-Yi Lee, Jeonghyeon Moon, Seung Tae Kim, Byung-Hoon Min, Tae Jun Kim, Sun Young Rha, Won Ki Kang, Woong-Yang Park, Samuel J. Klempner, Jeeyun Lee
Journal: Cancer Discovery
Cancer Discov (2022) 12 (4): 984–1001.
https://doi.org/10.1158/2159-8290.CD-21-0888
Published: 01 April 2022
View article titled, Early Tumor–Immune Microenvironmental Remodeling and Response to First-Line Fluoropyrimidine and Platinum Chemotherapy in Advanced Gastric Cancer
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Includes: Supplementary data
Journal Articles

Are You a TMBeliever? Mutations and Atezolizumab Response in Solid Tumors

Steven B. Maron, Samuel J. Klempner
Journal: Cancer Discovery
Cancer Discov (2022) 12 (3): 602–603.
https://doi.org/10.1158/2159-8290.CD-21-1642
Published: 08 March 2022
View article titled, Are You a TMBeliever? Mutations and Atezolizumab Response in Solid Tumors
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Journal Articles

Determinants of Response and Intrinsic Resistance to PD-1 Blockade in Microsatellite Instability–High Gastric Cancer

Minsuk Kwon, Minae An, Samuel J. Klempner, Hyuk Lee, Kyoung-Mee Kim, Jason K. Sa, Hee Jin Cho, Jung Yong Hong, Taehyang Lee, Yang Won Min, Tae Jun Kim, Byung-Hoon Min, Woong-Yang Park, Won Ki Kang, Kyu-Tae Kim, Seung Tae Kim, Jeeyun Lee
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2021) 11 (9): 2168–2185.
https://doi.org/10.1158/2159-8290.CD-21-0219
Published: 01 September 2021
View article titled, Determinants of Response and Intrinsic Resistance to PD-1 Blockade in Microsatellite Instability–High Gastric Cancer
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Includes: Supplementary data
Journal Articles

Clinical Acquired Resistance to KRASG12C Inhibition through a Novel KRAS Switch-II Pocket Mutation and Polyclonal Alterations Converging on RAS–MAPK Reactivation

Noritaka Tanaka, Jessica J. Lin, Chendi Li, Meagan B. Ryan, Junbing Zhang, Lesli A. Kiedrowski, Alexa G. Michel, Mohammed U. Syed, Katerina A. Fella, Mustafa Sakhi, Islam Baiev, Dejan Juric, Justin F. Gainor, Samuel J. Klempner, Jochen K. Lennerz, Giulia Siravegna, Liron Bar-Peled, Aaron N. Hata, Rebecca S. Heist, Ryan B. Corcoran
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2021) 11 (8): 1913–1922.
https://doi.org/10.1158/2159-8290.CD-21-0365
Published: 01 August 2021
View article titled, Clinical Acquired Resistance to KRAS<sup>G12C</sup> Inhibition through a Novel KRAS Switch-II Pocket Mutation and Polyclonal Alterations Converging on RAS–MAPK Reactivation
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Includes: Supplementary data
Journal Articles

Can the Help Match the Hype? KRASG12C-Specific Inhibitors and Beyond

Samuel J. Klempner, Aaron N. Hata
Journal: Cancer Discovery
Cancer Discov (2020) 10 (1): 20–22.
https://doi.org/10.1158/2159-8290.CD-19-1255
Published: 09 January 2020
View article titled, Can the Help Match the Hype? KRAS<sup>G12C</sup>-Specific Inhibitors and Beyond
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Journal Articles

Variety Is the Spice of Life, but Maybe Not in Gastroesophageal Adenocarcinomas

Samuel J. Klempner, Daniel V.T. Catenacci
Journal: Cancer Discovery
Cancer Discov (2019) 9 (2): 166–168.
https://doi.org/10.1158/2159-8290.CD-18-1447
Published: 08 February 2019
View article titled, Variety Is the Spice of Life, but Maybe Not in Gastroesophageal Adenocarcinomas
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Journal Articles

BRAFV600E Mutations in High-Grade Colorectal Neuroendocrine Tumors May Predict Responsiveness to BRAF–MEK Combination Therapy

Samuel J. Klempner, Bruce Gershenhorn, Phu Tran, Thomas K. Lee, Mark G. Erlander, Kyle Gowen, Alexa B. Schrock, Deborah Morosini, Jeffrey S. Ross, Vincent A. Miller, Philip J. Stephens, Sai-Hong Ignatius Ou, Siraj M. Ali
Journal: Cancer Discovery
Cancer Discov (2016) 6 (6): 594–600.
https://doi.org/10.1158/2159-8290.CD-15-1192
Published: 02 June 2016
View article titled, <em>BRAF</em><sup>V600E</sup> Mutations in High-Grade Colorectal Neuroendocrine Tumors May Predict Responsiveness to BRAF–MEK Combination Therapy
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Journal Articles

What a Tangled Web We Weave: Emerging Resistance Mechanisms to Inhibition of the Phosphoinositide 3-Kinase Pathway

Samuel J. Klempner, Andrea P. Myers, Lewis C. Cantley
Journal: Cancer Discovery
Cancer Discov (2013) 3 (12): 1345–1354.
https://doi.org/10.1158/2159-8290.CD-13-0063
Published: 10 December 2013
View article titled, What a Tangled Web We Weave: Emerging Resistance Mechanisms to Inhibition of the Phosphoinositide 3-Kinase Pathway
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