1-16 of 16
Ross L. Levine
Close
Save search
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles

Quantifying the Expanding Landscape of Clinical Actionability for Patients with Cancer

Sarah P. Suehnholz, Moriah H. Nissan, Hongxin Zhang, Ritika Kundra, Subhiksha Nandakumar, Calvin Lu, Stephanie Carrero, Amanda Dhaneshwar, Nicole Fernandez, Benjamin W. Xu, Maria E. Arcila, Ahmet ZEHIR, Aijazuddin Syed, A. Rose Brannon, Julia E. Rudolph, Eder Paraiso, Paul J. Sabbatini, Ross L. Levine, Ahmet Dogan, Jianjiong Gao, Marc Ladanyi, Alexander Drilon, Michael F. Berger, David B. Solit, Nikolaus Schultz, Debyani Chakravarty
Journal: Cancer Discovery
Cancer Discov (2023)
https://doi.org/10.1158/2159-8290.CD-23-0467
Published: 18 October 2023
View article titled, Quantifying the Expanding Landscape of Clinical Actionability for Patients with Cancer
Open the PDF for Quantifying the Expanding Landscape of Clinical Actionability for Patients with Cancer in another window
Includes: Supplementary data
Journal Articles

Oncogenic IDH1 Mutation Imparts Therapeutically Targetable Metabolic Dysfunction in Multiple Tumor Types

Troy M. Robinson, Ross L. Levine
Journal: Cancer Discovery
Cancer Discov (2023) 13 (2): 266–268.
https://doi.org/10.1158/2159-8290.CD-22-1325
Published: 06 February 2023
View article titled, Oncogenic <em>IDH1</em> Mutation Imparts Therapeutically Targetable Metabolic Dysfunction in Multiple Tumor Types
Open the PDF for Oncogenic <em>IDH1</em> Mutation Imparts Therapeutically Targetable Metabolic Dysfunction in Multiple Tumor Types in another window
Journal Articles

LKB1/STK11 Is a Tumor Suppressor in the Progression of Myeloproliferative Neoplasms

Christian Marinaccio, Praveen Suraneni, Hamza Celik, Andrew Volk, Qiang Jeremy Wen, Te Ling, Marinka Bulic, Terra Lasho, Richard P. Koche, Christopher A. Famulare, Noushin Farnoud, Brady Stein, Michael Schieber, Sandeep Gurbuxani, David E. Root, Scott T. Younger, Ronald Hoffman, Naseema Gangat, Panagiotis Ntziachristos, Navdeep S. Chandel, Ross L. Levine, Raajit K. Rampal, Grant A. Challen, Ayalew Tefferi, John D. Crispino
Journal: Cancer Discovery
Cancer Discov (2021) 11 (6): 1398–1410.
https://doi.org/10.1158/2159-8290.CD-20-1353
Published: 01 June 2021
View article titled, LKB1/<em>STK11</em> Is a Tumor Suppressor in the Progression of Myeloproliferative Neoplasms
Open the PDF for LKB1/<em>STK11</em> Is a Tumor Suppressor in the Progression of Myeloproliferative Neoplasms in another window
Includes: Supplementary data
Journal Articles

Somatic Mutations Drive Specific, but Reversible, Epigenetic Heterogeneity States in AML

Sheng Li, Xiaowen Chen, Jiahui Wang, Cem Meydan, Jacob L. Glass, Alan H. Shih, Ruud Delwel, Ross L. Levine, Christopher E. Mason, Ari M. Melnick
Journal: Cancer Discovery
Cancer Discov (2020) 10 (12): 1934–1949.
https://doi.org/10.1158/2159-8290.CD-19-0897
Published: 01 December 2020
View article titled, Somatic Mutations Drive Specific, but Reversible, Epigenetic Heterogeneity States in AML
Open the PDF for Somatic Mutations Drive Specific, but Reversible, Epigenetic Heterogeneity States in AML in another window
Includes: Supplementary data
Journal Articles

PRMT5 Inhibition Modulates E2F1 Methylation and Gene-Regulatory Networks Leading to Therapeutic Efficacy in JAK2V617F-Mutant MPN

Friederike Pastore, Neha Bhagwat, Alessandro Pastore, Aliaksandra Radzisheuskaya, Abdul Karzai, Aishwarya Krishnan, Bing Li, Robert L. Bowman, Wenbin Xiao, Aaron D. Viny, Anouar Zouak, Young C. Park, Keith B. Cordner, Stephanie Braunstein, Jesper L. Maag, Alexander Grego, Jaanvi Mehta, Min Wang, Hong Lin, Benjamin H. Durham, Richard P. Koche, Raajit K. Rampal, Kristian Helin, Peggy Scherle, Kris Vaddi, Ross L. Levine
Journal: Cancer Discovery
Cancer Discov (2020) 10 (11): 1742–1757.
https://doi.org/10.1158/2159-8290.CD-20-0026
Published: 02 November 2020
View article titled, PRMT5 Inhibition Modulates E2F1 Methylation and Gene-Regulatory Networks Leading to Therapeutic Efficacy in JAK2<sup>V617F</sup>-Mutant MPN
Open the PDF for PRMT5 Inhibition Modulates E2F1 Methylation and Gene-Regulatory Networks Leading to Therapeutic Efficacy in JAK2<sup>V617F</sup>-Mutant MPN in another window
Includes: Supplementary data
Journal Articles

Leukemia Cell of Origin Influences Apoptotic Priming and Sensitivity to LSD1 Inhibition

Sheng F. Cai, S. Haihua Chu, Aaron D. Goldberg, Salma Parvin, Richard P. Koche, Jacob L. Glass, Eytan M. Stein, Martin S. Tallman, Filiz Sen, Christopher A. Famulare, Monica Cusan, Chun-Hao Huang, Chun-Wei Chen, Lihua Zou, Keith B. Cordner, Nicole L. DelGaudio, Vidushi Durani, Mitali Kini, Madison Rex, Helen S. Tian, Johannes Zuber, Timour Baslan, Scott W. Lowe, Hugh Y. Rienhoff, Jr, Anthony Letai, Ross L. Levine, Scott A. Armstrong
Journal: Cancer Discovery
Cancer Discov (2020) 10 (10): 1500–1513.
https://doi.org/10.1158/2159-8290.CD-19-1469
Published: 01 October 2020
View article titled, Leukemia Cell of Origin Influences Apoptotic Priming and Sensitivity to LSD1 Inhibition
Open the PDF for Leukemia Cell of Origin Influences Apoptotic Priming and Sensitivity to LSD1 Inhibition in another window
Includes: Supplementary data
Journal Articles

Rational Targeting of Cooperating Layers of the Epigenome Yields Enhanced Therapeutic Efficacy against AML

Cihangir Duy, Matt Teater, Francine E. Garrett-Bakelman, Tak C. Lee, Cem Meydan, Jacob L. Glass, Meng Li, Johannes C. Hellmuth, Helai P. Mohammad, Kimberly N. Smitheman, Alan H. Shih, Omar Abdel-Wahab, Martin S. Tallman, Monica L. Guzman, David Muench, H. Leighton Grimes, Gail J. Roboz, Ryan G. Kruger, Caretha L. Creasy, Elisabeth M. Paietta, Ross L. Levine, Martin Carroll, Ari M. Melnick
Journal: Cancer Discovery
Cancer Discov (2019) 9 (7): 872–889.
https://doi.org/10.1158/2159-8290.CD-19-0106
Published: 01 July 2019
View article titled, Rational Targeting of Cooperating Layers of the Epigenome Yields Enhanced Therapeutic Efficacy against AML
Open the PDF for Rational Targeting of Cooperating Layers of the Epigenome Yields Enhanced Therapeutic Efficacy against AML in another window
Includes: Supplementary data
Journal Articles

Cytokine-Regulated Phosphorylation and Activation of TET2 by JAK2 in Hematopoiesis

Jong Jin Jeong, Xiaorong Gu, Ji Nie, Sriram Sundaravel, Hui Liu, Wen-Liang Kuo, Tushar D. Bhagat, Kith Pradhan, John Cao, Sangeeta Nischal, Kathy L. McGraw, Sanchari Bhattacharyya, Michael R. Bishop, Andrew Artz, Michael J. Thirman, Alison Moliterno, Peng Ji, Ross L. Levine, Lucy A. Godley, Ulrich Steidl, James J. Bieker, Alan F. List, Yogen Saunthararajah, Chuan He, Amit Verma, Amittha Wickrema
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2019) 9 (6): 778–795.
https://doi.org/10.1158/2159-8290.CD-18-1138
Published: 03 June 2019
View article titled, Cytokine-Regulated Phosphorylation and Activation of TET2 by JAK2 in Hematopoiesis
Open the PDF for Cytokine-Regulated Phosphorylation and Activation of TET2 by JAK2 in Hematopoiesis in another window
Journal Articles

Mutant and Wild-Type Isocitrate Dehydrogenase 1 Share Enhancing Mechanisms Involving Distinct Tyrosine Kinase Cascades in Cancer

Dong Chen, Siyuan Xia, Mei Wang, Ruiting Lin, Yuancheng Li, Hui Mao, Mike Aguiar, Christopher A. Famulare, Alan H. Shih, Cameron W. Brennan, Xue Gao, Yaozhu Pan, Shuangping Liu, Jun Fan, Lingtao Jin, Lina Song, An Zhou, Joydeep Mukherjee, Russell O. Pieper, Ashutosh Mishra, Junmin Peng, Martha Arellano, William G. Blum, Sagar Lonial, Titus J. Boggon, Ross L. Levine, Jing Chen
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2019) 9 (6): 756–777.
https://doi.org/10.1158/2159-8290.CD-18-1040
Published: 03 June 2019
View article titled, Mutant and Wild-Type Isocitrate Dehydrogenase 1 Share Enhancing Mechanisms Involving Distinct Tyrosine Kinase Cascades in Cancer
Open the PDF for Mutant and Wild-Type Isocitrate Dehydrogenase 1 Share Enhancing Mechanisms Involving Distinct Tyrosine Kinase Cascades in Cancer in another window
Journal Articles

TET2 Deficiency Causes Germinal Center Hyperplasia, Impairs Plasma Cell Differentiation, and Promotes B-cell Lymphomagenesis

Pilar M. Dominguez, Hussein Ghamlouch, Wojciech Rosikiewicz, Parveen Kumar, Wendy Béguelin, Lorena Fontán, Martín A. Rivas, Patrycja Pawlikowska, Marine Armand, Enguerran Mouly, Miguel Torres-Martin, Ashley S. Doane, María T. Calvo Fernandez, Matt Durant, Veronique Della-Valle, Matt Teater, Luisa Cimmino, Nathalie Droin, Saber Tadros, Samaneh Motanagh, Alan H. Shih, Mark A. Rubin, Wayne Tam, Iannis Aifantis, Ross L. Levine, Olivier Elemento, Giorgio Inghirami, Michael R. Green, Maria E. Figueroa, Olivier A. Bernard, Said Aoufouchi, Sheng Li, Rita Shaknovich, Ari M. Melnick
Journal: Cancer Discovery
Cancer Discov (2018) 8 (12): 1632–1653.
https://doi.org/10.1158/2159-8290.CD-18-0657
Published: 03 December 2018
View article titled, TET2 Deficiency Causes Germinal Center Hyperplasia, Impairs Plasma Cell Differentiation, and Promotes B-cell Lymphomagenesis
Open the PDF for TET2 Deficiency Causes Germinal Center Hyperplasia, Impairs Plasma Cell Differentiation, and Promotes B-cell Lymphomagenesis in another window
Includes: Supplementary data
Journal Articles

Isoform Switching as a Mechanism of Acquired Resistance to Mutant Isocitrate Dehydrogenase Inhibition

James J. Harding, Maeve A. Lowery, Alan H. Shih, Juan M. Schvartzman, Shengqi Hou, Christopher Famulare, Minal Patel, Mikhail Roshal, Richard K. Do, Ahmet Zehir, Daoqi You, S. Duygu Selcuklu, Agnes Viale, Martin S. Tallman, David M. Hyman, Ed Reznik, Lydia W.S. Finley, Elli Papaemmanuil, Alessandra Tosolini, Mark G. Frattini, Kyle J. MacBeth, Guowen Liu, Bin Fan, Sung Choe, Bin Wu, Yelena Y. Janjigian, Ingo K. Mellinghoff, Luis A. Diaz, Ross L. Levine, Ghassan K. Abou-Alfa, Eytan M. Stein, Andrew M. Intlekofer
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2018) 8 (12): 1540–1547.
https://doi.org/10.1158/2159-8290.CD-18-0877
Published: 03 December 2018
View article titled, Isoform Switching as a Mechanism of Acquired Resistance to Mutant Isocitrate Dehydrogenase Inhibition
Open the PDF for Isoform Switching as a Mechanism of Acquired Resistance to Mutant Isocitrate Dehydrogenase Inhibition in another window
Includes: Supplementary data
Journal Articles

Combination Targeted Therapy to Disrupt Aberrant Oncogenic Signaling and Reverse Epigenetic Dysfunction in IDH2- and TET2-Mutant Acute Myeloid Leukemia

Alan H. Shih, Cem Meydan, Kaitlyn Shank, Francine E. Garrett-Bakelman, Patrick S. Ward, Andrew M. Intlekofer, Abbas Nazir, Eytan M. Stein, Kristina Knapp, Jacob Glass, Jeremy Travins, Kim Straley, Camelia Gliser, Christopher E. Mason, Katharine Yen, Craig B. Thompson, Ari Melnick, Ross L. Levine
Journal: Cancer Discovery
Cancer Discov (2017) 7 (5): 494–505.
https://doi.org/10.1158/2159-8290.CD-16-1049
Published: 30 April 2017
View article titled, Combination Targeted Therapy to Disrupt Aberrant Oncogenic Signaling and Reverse Epigenetic Dysfunction in <em>IDH2</em>- and <em>TET2</em>-Mutant Acute Myeloid Leukemia
Open the PDF for Combination Targeted Therapy to Disrupt Aberrant Oncogenic Signaling and Reverse Epigenetic Dysfunction in <em>IDH2</em>- and <em>TET2</em>-Mutant Acute Myeloid Leukemia in another window
Includes: Supplementary data
Journal Articles

JAK–STAT Pathway Activation in Malignant and Nonmalignant Cells Contributes to MPN Pathogenesis and Therapeutic Response

Maria Kleppe, Minsuk Kwak, Priya Koppikar, Markus Riester, Matthew Keller, Lennart Bastian, Todd Hricik, Neha Bhagwat, Anna Sophia McKenney, Efthymia Papalexi, Omar Abdel-Wahab, Raajit Rampal, Sachie Marubayashi, Jonathan J. Chen, Vincent Romanet, Jordan S. Fridman, Jacqueline Bromberg, Julie Teruya-Feldstein, Masato Murakami, Thomas Radimerski, Franziska Michor, Rong Fan, Ross L. Levine
Journal: Cancer Discovery
Cancer Discov (2015) 5 (3): 316–331.
https://doi.org/10.1158/2159-8290.CD-14-0736
Published: 05 March 2015
View article titled, JAK–STAT Pathway Activation in Malignant and Nonmalignant Cells Contributes to MPN Pathogenesis and Therapeutic Response
Open the PDF for JAK–STAT Pathway Activation in Malignant and Nonmalignant Cells Contributes to MPN Pathogenesis and Therapeutic Response in another window
Includes: Supplementary data
Journal Articles

Efficacy of Intermittent Combined RAF and MEK Inhibition in a Patient with Concurrent BRAF- and NRAS-Mutant Malignancies

Omar Abdel-Wahab, Virginia M. Klimek, Alisa A. Gaskell, Agnes Viale, Donavan Cheng, Eunhee Kim, Raajit Rampal, Mark Bluth, James J. Harding, Margaret K. Callahan, Taha Merghoub, Michael F. Berger, David B. Solit, Neal Rosen, Ross L. Levine, Paul B. Chapman
Journal: Cancer Discovery
Cancer Discov (2014) 4 (5): 538–545.
https://doi.org/10.1158/2159-8290.CD-13-1038
Published: 01 May 2014
View article titled, Efficacy of Intermittent Combined RAF and MEK Inhibition in a Patient with Concurrent BRAF- and NRAS-Mutant Malignancies
Open the PDF for Efficacy of Intermittent Combined RAF and MEK Inhibition in a Patient with Concurrent BRAF- and NRAS-Mutant Malignancies in another window
Includes: Supplementary data
Journal Articles

TYK2–STAT1–BCL2 Pathway Dependence in T-cell Acute Lymphoblastic Leukemia

Takaomi Sanda, Jeffrey W. Tyner, Alejandro Gutierrez, Vu N. Ngo, Jason Glover, Bill H. Chang, Arla Yost, Wenxue Ma, Angela G. Fleischman, Wenjun Zhou, Yandan Yang, Maria Kleppe, Yebin Ahn, Jessica Tatarek, Michelle A. Kelliher, Donna S. Neuberg, Ross L. Levine, Richard Moriggl, Mathias Müller, Nathanael S. Gray, Catriona H.M. Jamieson, Andrew P. Weng, Louis M. Staudt, Brian J. Druker, A. Thomas Look
Journal: Cancer Discovery
Cancer Discov (2013) 3 (5): 564–577.
https://doi.org/10.1158/2159-8290.CD-12-0504
Published: 08 May 2013
View article titled, TYK2–STAT1–BCL2 Pathway Dependence in T-cell Acute Lymphoblastic Leukemia
Open the PDF for TYK2–STAT1–BCL2 Pathway Dependence in T-cell Acute Lymphoblastic Leukemia in another window
Includes: Supplementary data
Journal Articles

Modulation of Activation-Loop Phosphorylation by JAK Inhibitors Is Binding Mode Dependent

Rita Andraos, Zhiyan Qian, Débora Bonenfant, Joëlle Rubert, Eric Vangrevelinghe, Clemens Scheufler, Fanny Marque, Catherine H. Régnier, Alain De Pover, Hugues Ryckelynck, Neha Bhagwat, Priya Koppikar, Aviva Goel, Lorenza Wyder, Gisele Tavares, Fabienne Baffert, Carole Pissot-Soldermann, Paul W. Manley, Christoph Gaul, Hans Voshol, Ross L. Levine, William R. Sellers, Francesco Hofmann, Thomas Radimerski
Journal: Cancer Discovery
Cancer Discov (2012) 2 (6): 512–523.
https://doi.org/10.1158/2159-8290.CD-11-0324
Published: 07 June 2012
View article titled, Modulation of Activation-Loop Phosphorylation by JAK Inhibitors Is Binding Mode Dependent
Open the PDF for Modulation of Activation-Loop Phosphorylation by JAK Inhibitors Is Binding Mode Dependent in another window
Includes: Supplementary data