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Roger S. Lo
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Journal Articles

Expression of Concern: Exploiting Drug Addiction Mechanisms to Select against MAPKi-Resistant Melanoma

Free
Aayoung Hong, Gatien Moriceau, Lu Sun, Shirley Lomeli, Marco Piva, Robert Damoiseaux, Sheri L. Holmen, Norman E. Sharpless, Willy Hugo, Roger S. Lo
Journal: Cancer Discovery
Cancer Discov (2024) 14 (7): 1356.
https://doi.org/10.1158/2159-8290.CD-24-0612
Published: 01 July 2024
View articletitled, Expression of Concern: Exploiting Drug Addiction Mechanisms to Select against MAPKi-Resistant Melanoma
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Journal Articles

Expression of Concern: Durable Suppression of Acquired MEK Inhibitor Resistance in Cancer by Sequestering MEK from ERK and Promoting Antitumor T-cell Immunity

Free
Aayoung Hong, Marco Piva, Sixue Liu, Willy Hugo, Shirley H. Lomeli, Vincent Zoete, Christopher E. Randolph, Zhentao Yang, Yan Wang, Jordan J. Lee, Skylar J. Lo, Lu Sun, Agustin Vega-Crespo, Alejandro J. Garcia, David B. Shackelford, Steven M. Dubinett, Philip O. Scumpia, Stephanie D. Byrum, Alan J. Tackett, Timothy R. Donahue, Olivier Michielin, Sheri L. Holmen, Antoni Ribas, Gatien Moriceau, Roger S. Lo
Journal: Cancer Discovery
Cancer Discov (2024) 14 (7): 1357.
https://doi.org/10.1158/2159-8290.CD-24-0613
Published: 01 July 2024
View articletitled, Expression of Concern: Durable Suppression of Acquired MEK Inhibitor Resistance in Cancer by Sequestering MEK from ERK and Promoting Antitumor T-cell Immunity
Open the PDF for Expression of Concern: Durable Suppression of Acquired MEK Inhibitor Resistance in Cancer by Sequestering MEK from ERK and Promoting Antitumor T-cell Immunity in another window
Journal Articles

Blocking Genomic Instability Prevents Acquired Resistance to MAPK Inhibitor Therapy in Melanoma

Open Access
Prashanthi Dharanipragada, Xiao Zhang, Sixue Liu, Shirley H. Lomeli, Aayoung Hong, Yan Wang, Zhentao Yang, Kara Z. Lo, Agustin Vega-Crespo, Antoni Ribas, Stergios J. Moschos, Gatien Moriceau, Roger S. Lo
Journal: Cancer Discovery
Cancer Discov (2023) 13 (4): 880–909.
https://doi.org/10.1158/2159-8290.CD-22-0787
Published: 03 April 2023
View articletitled, Blocking Genomic Instability Prevents Acquired Resistance to MAPK Inhibitor Therapy in Melanoma
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Includes: Supplementary data
Journal Articles

Enhancing PD-L1 Degradation by ITCH during MAPK Inhibitor Therapy Suppresses Acquired Resistance

Open Access
Zhentao Yang, Yan Wang, Sixue Liu, Weixian Deng, Shirley H. Lomeli, Gatien Moriceau, James Wohlschlegel, Marco Piva, Roger S. Lo
Journal: Cancer Discovery
Cancer Discov (2022) 12 (8): 1942–1959.
https://doi.org/10.1158/2159-8290.CD-21-1463
Published: 05 August 2022
View articletitled, Enhancing PD-L1 Degradation by ITCH during MAPK Inhibitor Therapy Suppresses Acquired Resistance
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Includes: Supplementary data
Journal Articles

Plasticity of Extrachromosomal and Intrachromosomal BRAF Amplifications in Overcoming Targeted Therapy Dosage Challenges

Available to Purchase
Kai Song, Jenna K. Minami, Arthur Huang, Siavash R. Dehkordi, Shirley H. Lomeli, Jens Luebeck, Mark H. Goodman, Gatien Moriceau, Oscar Krijgsman, Prashanthi Dharanipragada, Trevor Ridgley, William P. Crosson, Jesus Salazar, Eli Pazol, Gabriel Karin, Rachana Jayaraman, Nikolas G. Balanis, Salwan Alhani, Kyle Sheu, Johanna ten Hoeve, Amelia Palermo, Stephen E. Motika, T. Niroshi Senaratne, Kim H. Paraiso, Paul J. Hergenrother, P. Nagesh Rao, Asha S. Multani, Daniel S. Peeper, Vineet Bafna, Roger S. Lo, Thomas G. Graeber
Journal: Cancer Discovery
Cancer Discov (2022) 12 (4): 1046–1069.
https://doi.org/10.1158/2159-8290.CD-20-0936
Published: 01 April 2022
View articletitled, Plasticity of Extrachromosomal and Intrachromosomal BRAF Amplifications in Overcoming Targeted Therapy Dosage Challenges
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Includes: Supplementary data
Journal Articles

Durable Suppression of Acquired MEK Inhibitor Resistance in Cancer by Sequestering MEK from ERK and Promoting Antitumor T-cell Immunity

Free
Aayoung Hong, Marco Piva, Sixue Liu, Willy Hugo, Shirley H. Lomeli, Vincent Zoete, Christopher E. Randolph, Zhentao Yang, Yan Wang, Jordan J. Lee, Skylar J. Lo, Lu Sun, Agustin Vega-Crespo, Alejandro J. Garcia, David B. Shackelford, Steven M. Dubinett, Philip O. Scumpia, Stephanie D. Byrum, Alan J. Tackett, Timothy R. Donahue, Olivier Michielin, Sheri L. Holmen, Antoni Ribas, Gatien Moriceau, Roger S. Lo
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2021) 11 (3): 714–735.
https://doi.org/10.1158/2159-8290.CD-20-0873
Published: 02 March 2021
View articletitled, Durable Suppression of Acquired MEK Inhibitor Resistance in Cancer by Sequestering MEK from ERK and Promoting Antitumor T-cell Immunity
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Includes: Supplementary data
Journal Articles

Trying for a BRAF Slam Dunk

Available to Purchase
Antoni Ribas, Roger S. Lo
Journal: Cancer Discovery
Cancer Discov (2020) 10 (5): 640–642.
https://doi.org/10.1158/2159-8290.CD-20-0231
Published: 01 May 2020
View articletitled, Trying for a BRAF Slam Dunk
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Journal Articles

Exploiting Drug Addiction Mechanisms to Select against MAPKi-Resistant Melanoma

Free
Aayoung Hong, Gatien Moriceau, Lu Sun, Shirley Lomeli, Marco Piva, Robert Damoiseaux, Sheri L. Holmen, Norman E. Sharpless, Willy Hugo, Roger S. Lo
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2018) 8 (1): 74–93.
https://doi.org/10.1158/2159-8290.CD-17-0682
Published: 07 January 2018
View articletitled, Exploiting Drug Addiction Mechanisms to Select against MAPKi-Resistant Melanoma
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Includes: Supplementary data
Journal Articles

Recurrent Tumor Cell–Intrinsic and –Extrinsic Alterations during MAPKi-Induced Melanoma Regression and Early Adaptation

Free
Chunying Song, Marco Piva, Lu Sun, Aayoung Hong, Gatien Moriceau, Xiangju Kong, Hong Zhang, Shirley Lomeli, Jin Qian, Clarissa C. Yu, Robert Damoiseaux, Mark C. Kelley, Kimberley B. Dahlman, Philip O. Scumpia, Jeffrey A. Sosman, Douglas B. Johnson, Antoni Ribas, Willy Hugo, Roger S. Lo
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2017) 7 (11): 1248–1265.
https://doi.org/10.1158/2159-8290.CD-17-0401
Published: 01 November 2017
View articletitled, Recurrent Tumor Cell–Intrinsic and –Extrinsic Alterations during MAPKi-Induced Melanoma Regression and Early Adaptation
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Includes: Supplementary data
Journal Articles

Primary Resistance to PD-1 Blockade Mediated by JAK1/2 Mutations

Free
Daniel Sanghoon Shin, Jesse M. Zaretsky, Helena Escuin-Ordinas, Angel Garcia-Diaz, Siwen Hu-Lieskovan, Anusha Kalbasi, Catherine S. Grasso, Willy Hugo, Salemiz Sandoval, Davis Y. Torrejon, Nicolaos Palaskas, Gabriel Abril Rodriguez, Giulia Parisi, Ariel Azhdam, Bartosz Chmielowski, Grace Cherry, Elizabeth Seja, Beata Berent-Maoz, I. Peter Shintaku, Dung T. Le, Drew M. Pardoll, Luis A. Diaz, Jr, Paul C. Tumeh, Thomas G. Graeber, Roger S. Lo, Begoña Comin-Anduix, Antoni Ribas
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2017) 7 (2): 188–201.
https://doi.org/10.1158/2159-8290.CD-16-1223
Published: 05 February 2017
View articletitled, Primary Resistance to PD-1 Blockade Mediated by JAK1/2 Mutations
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Includes: Supplementary data
Journal Articles

Response of BRAF-Mutant Melanoma to BRAF Inhibition Is Mediated by a Network of Transcriptional Regulators of Glycolysis

Free
Tiffany J. Parmenter, Margarete Kleinschmidt, Kathryn M. Kinross, Simon T. Bond, Jason Li, Mohan R. Kaadige, Aparna Rao, Karen E. Sheppard, Willy Hugo, Gulietta M. Pupo, Richard B. Pearson, Sean L. McGee, Georgina V. Long, Richard A. Scolyer, Helen Rizos, Roger S. Lo, Carleen Cullinane, Donald E. Ayer, Antoni Ribas, Ricky W. Johnstone, Rodney J. Hicks, Grant A. McArthur
Journal: Cancer Discovery
Cancer Discov (2014) 4 (4): 423–433.
https://doi.org/10.1158/2159-8290.CD-13-0440
Published: 03 April 2014
View articletitled, Response of BRAF-Mutant Melanoma to BRAF Inhibition Is Mediated by a Network of Transcriptional Regulators of Glycolysis
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Includes: Supplementary data
Journal Articles

Acquired Resistance and Clonal Evolution in Melanoma during BRAF Inhibitor Therapy

Free
Hubing Shi, Willy Hugo, Xiangju Kong, Aayoung Hong, Richard C. Koya, Gatien Moriceau, Thinle Chodon, Rongqing Guo, Douglas B. Johnson, Kimberly B. Dahlman, Mark C. Kelley, Richard F. Kefford, Bartosz Chmielowski, John A. Glaspy, Jeffrey A. Sosman, Nicolas van Baren, Georgina V. Long, Antoni Ribas, Roger S. Lo
Journal: Cancer Discovery
Cancer Discov (2014) 4 (1): 80–93.
https://doi.org/10.1158/2159-8290.CD-13-0642
Published: 07 January 2014
View articletitled, Acquired Resistance and Clonal Evolution in Melanoma during BRAF Inhibitor Therapy
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Includes: Supplementary data
Journal Articles

A Novel AKT1 Mutant Amplifies an Adaptive Melanoma Response to BRAF Inhibition

Free
Hubing Shi, Aayoung Hong, Xiangju Kong, Richard C. Koya, Chunying Song, Gatien Moriceau, Willy Hugo, Clarissa C. Yu, Charles Ng, Thinle Chodon, Richard A. Scolyer, Richard F. Kefford, Antoni Ribas, Georgina V. Long, Roger S. Lo
Journal: Cancer Discovery
Cancer Discov (2014) 4 (1): 69–79.
https://doi.org/10.1158/2159-8290.CD-13-0279
Published: 07 January 2014
View articletitled, A Novel AKT1 Mutant Amplifies an Adaptive Melanoma Response to BRAF Inhibition
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Includes: Supplementary data
Journal Articles

Preexisting MEK1 Exon 3 Mutations in V600E/KBRAF Melanomas Do Not Confer Resistance to BRAF Inhibitors

Free
Hubing Shi, Gatien Moriceau, Xiangju Kong, Richard C. Koya, Ramin Nazarian, Gulietta M. Pupo, Antonella Bacchiocchi, Kimberly B. Dahlman, Bartosz Chmielowski, Jeffrey A. Sosman, Ruth Halaban, Richard F. Kefford, Georgina V. Long, Antoni Ribas, Roger S. Lo
Journal: Cancer Discovery
Cancer Discov (2012) 2 (5): 414–424.
https://doi.org/10.1158/2159-8290.CD-12-0022
Published: 09 May 2012
View articletitled, Preexisting MEK1 Exon 3 Mutations in V600E/KBRAF Melanomas Do Not Confer Resistance to BRAF Inhibitors
Open the PDF for Preexisting MEK1 Exon 3 Mutations in V600E/KBRAF Melanomas Do Not Confer Resistance to BRAF Inhibitors in another window
Includes: Supplementary data