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Robert H. Vonderheide
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Journal Articles

T-cell dependency of tumor regressions and complete responses with RAS(ON) multi-selective inhibition in preclinical models of PDAC

Margo I. Orlen, William P. Vostrejs, Rina Sor, Jayne C. McDevitt, Samantha B. Kemp, Il-Kyu Kim, Adam B. Kramer, Nataliya Tovbis Shifrin, Nune Markosyan, Cynthia Clendenin, Mallika Singh, Elsa Quintana, Marie Menard, Robert H. Vonderheide, Ben Z. Stanger
Journal: Cancer Discovery
Cancer Discov (2025)
https://doi.org/10.1158/2159-8290.CD-24-1475
Published: 07 March 2025
View articletitled, T-cell dependency of tumor regressions and complete responses with RAS(ON) multi-selective inhibition in preclinical models of PDAC
Open the PDF for T-cell dependency of tumor regressions and complete responses with RAS(ON) multi-selective inhibition in preclinical models of PDAC in another window
Includes: Supplementary data
Journal Articles

Advancing Cancer Interception

Susan M. Domchek, Robert H. Vonderheide
Journal: Cancer Discovery
Cancer Discov (2024) 14 (4): 600–604.
https://doi.org/10.1158/2159-8290.CD-24-0015
Published: 04 April 2024
View articletitled, Advancing Cancer Interception
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Journal Articles

Efficacy of a Small-Molecule Inhibitor of KrasG12D in Immunocompetent Models of Pancreatic Cancer

Samantha B. Kemp, Noah Cheng, Nune Markosyan, Rina Sor, Il-Kyu Kim, Jill Hallin, Jason Shoush, Liz Quinones, Natalie V. Brown, Jared B. Bassett, Nikhil Joshi, Salina Yuan, Molly Smith, William P. Vostrejs, Kia Z. Perez-Vale, Benjamin Kahn, Feiyan Mo, Timothy R. Donahue, Caius G. Radu, Cynthia Clendenin, James G. Christensen, Robert H. Vonderheide, Ben Z. Stanger
Journal: Cancer Discovery
Cancer Discov (2023) 13 (2): 298–311.
https://doi.org/10.1158/2159-8290.CD-22-1066
Published: 06 February 2023
View articletitled, Efficacy of a Small-Molecule Inhibitor of KrasG12D in Immunocompetent Models of Pancreatic Cancer
Open the PDF for Efficacy of a Small-Molecule Inhibitor of KrasG12D in Immunocompetent Models of Pancreatic Cancer in another window
Includes: Supplementary data
Journal Articles

Leukocyte Heterogeneity in Pancreatic Ductal Adenocarcinoma: Phenotypic and Spatial Features Associated with Clinical Outcome

Shannon M. Liudahl, Courtney B. Betts, Shamilene Sivagnanam, Vicente Morales-Oyarvide, Annacarolina da Silva, Chen Yuan, Samuel Hwang, Alison Grossblatt-Wait, Kenna R. Leis, William Larson, Meghan B. Lavoie, Padraic Robinson, Andressa Dias Costa, Sara A. Väyrynen, Thomas E. Clancy, Douglas A. Rubinson, Jason Link, Dove Keith, Wesley Horton, Margaret A. Tempero, Robert H. Vonderheide, Elizabeth M. Jaffee, Brett Sheppard, Jeremy Goecks, Rosalie C. Sears, Byung S. Park, Motomi Mori, Jonathan A. Nowak, Brian M. Wolpin, Lisa M. Coussens
Journal: Cancer Discovery
Cancer Discov (2021) 11 (8): 2014–2031.
https://doi.org/10.1158/2159-8290.CD-20-0841
Published: 01 August 2021
View articletitled, Leukocyte Heterogeneity in Pancreatic Ductal Adenocarcinoma: Phenotypic and Spatial Features Associated with Clinical Outcome
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Includes: Supplementary data
Journal Articles

Epigenetic and Transcriptional Control of the Epidermal Growth Factor Receptor Regulates the Tumor Immune Microenvironment in Pancreatic Cancer

Jinyang Li, Salina Yuan, Robert J. Norgard, Fangxue Yan, Yu H. Sun, Il-Kyu Kim, Allyson J. Merrell, Yogev Sela, Yanqing Jiang, Natarajan V. Bhanu, Benjamin A. Garcia, Robert H. Vonderheide, Andrés Blanco, Ben Z. Stanger
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2021) 11 (3): 736–753.
https://doi.org/10.1158/2159-8290.CD-20-0519
Published: 02 March 2021
View articletitled, Epigenetic and Transcriptional Control of the Epidermal Growth Factor Receptor Regulates the Tumor Immune Microenvironment in Pancreatic Cancer
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Includes: Supplementary data
Journal Articles

Hif1a Deletion Reveals Pro-Neoplastic Function of B Cells in Pancreatic Neoplasia

Kyoung Eun Lee, Michelle Spata, Lauren J. Bayne, Elizabeth L. Buza, Amy C. Durham, David Allman, Robert H. Vonderheide, M. Celeste Simon
Journal: Cancer Discovery
Cancer Discov (2016) 6 (3): 256–269.
https://doi.org/10.1158/2159-8290.CD-15-0822
Published: 06 March 2016
View articletitled, Hif1a Deletion Reveals Pro-Neoplastic Function of B Cells in Pancreatic Neoplasia
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Includes: Supplementary data
Journal Articles

Dynamic Interplay of Oncogenes and T Cells Induces PD-L1 in the Tumor Microenvironment

Andrew J. Rech, Robert H. Vonderheide
Journal: Cancer Discovery
Cancer Discov (2013) 3 (12): 1330–1332.
https://doi.org/10.1158/2159-8290.CD-13-0775
Published: 10 December 2013
View articletitled, Dynamic Interplay of Oncogenes and T Cells Induces PD-L1 in the Tumor Microenvironment
Open the PDF for Dynamic Interplay of Oncogenes and T Cells Induces PD-L1 in the Tumor Microenvironment in another window