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Richard P. Koche
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Journal Articles

CRISPR Dependency Screens in Primary Hematopoietic Stem Cells Identify KDM3B as a Genotype-specific Vulnerability in IDH2- and TET2-mutant Cells

Michael R. Waarts, Shoron Mowla, Meaghan Boileau, Anthony R. Martinez Benitez, Junya Sango, Maya Bagish, Inés Fernández-Maestre, Yufan Shan, Shira E. Eisman, Young C. Park, Matthew Wereski, Isabelle Csete, Kavi O’Connor, Angelica C. Romero-Vega, Linde A. Miles, Wenbin Xiao, Xiaodi Wu, Richard P. Koche, Scott A. Armstrong, Alan H. Shih, Eirini P. Papapetrou, Jason M. Butler, Sheng F. Cai, Robert L. Bowman, Ross L. Levine
Journal: Cancer Discovery
Cancer Discov OF1–OF19.
https://doi.org/10.1158/2159-8290.CD-23-1092
Published: 13 August 2024
View article titled, CRISPR Dependency Screens in Primary Hematopoietic Stem Cells Identify <em>KDM3B</em> as a Genotype-specific Vulnerability in <em>IDH2</em>- and <em>TET2</em>-mutant Cells
Open the PDF for CRISPR Dependency Screens in Primary Hematopoietic Stem Cells Identify <em>KDM3B</em> as a Genotype-specific Vulnerability in <em>IDH2</em>- and <em>TET2</em>-mutant Cells in another window
Includes: Supplementary data
Journal Articles

Jak2V617F Reversible Activation Shows Its Essential Requirement in Myeloproliferative Neoplasms

Andrew J. Dunbar, Robert L. Bowman, Young C. Park, Kavi O'Connor, Franco Izzo, Robert M. Myers, Abdul Karzai, Zachary Zaroogian, Won Jun Kim, Inés Fernández-Maestre, Michael R. Waarts, Abbas Nazir, Wenbin Xiao, Tamara Codilupi, Max Brodsky, Mirko Farina, Louise Cai, Sheng F. Cai, Benjamin Wang, Wenbin An, Julie L. Yang, Shoron Mowla, Shira E. Eisman, Amritha Varshini Hanasoge Somasundara, Jacob L. Glass, Tanmay Mishra, Remie Houston, Emily Guzzardi, Anthony R. Martinez Benitez, Aaron D. Viny, Richard P. Koche, Sara C. Meyer, Dan A. Landau, Ross L. Levine
Journal: Cancer Discovery
Cancer Discov (2024) 14 (5): 737–751.
https://doi.org/10.1158/2159-8290.CD-22-0952
Published: 01 May 2024
View article titled, Jak2<sup>V617F</sup> Reversible Activation Shows Its Essential Requirement in Myeloproliferative Neoplasms
Open the PDF for Jak2<sup>V617F</sup> Reversible Activation Shows Its Essential Requirement in Myeloproliferative Neoplasms in another window
Includes: Supplementary data
Journal Articles

Passenger Gene Coamplifications Create Collateral Therapeutic Vulnerabilities in Cancer

Yi Bei, Luca Bramé, Marieluise Kirchner, Raphaela Fritsche-Guenther, Severine Kunz, Animesh Bhattacharya, Mara-Camelia Rusu, Dennis Gürgen, Frank P.B. Dubios, Julia K.C. Köppke, Jutta Proba, Nadine Wittstruck, Olga Alexandra Sidorova, Rocío Chamorro González, Heathcliff Dorado Garcia, Lotte Brückner, Robin Xu, Mădălina Giurgiu, Elias Rodriguez-Fos, Qinghao Yu, Bastiaan Spanjaard, Richard P. Koche, Clemens A. Schmitt, Johannes H. Schulte, Angelika Eggert, Kerstin Haase, Jennifer Kirwan, Anja I.H. Hagemann, Philipp Mertins, Jan R. Dörr, Anton G. Henssen
Journal: Cancer Discovery
Cancer Discov (2024) 14 (3): 492–507.
https://doi.org/10.1158/2159-8290.CD-23-1189
Published: 01 March 2024
View article titled, Passenger Gene Coamplifications Create Collateral Therapeutic Vulnerabilities in Cancer
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Includes: Supplementary data
Journal Articles

Disruption of SUV39H1-Mediated H3K9 Methylation Sustains CAR T-cell Function

Nayan Jain, Zeguo Zhao, Richard P. Koche, Chenling Antelope, Yosi Gozlan, Antonino Montalbano, David Brocks, Michael Lopez, Anton Dobrin, Yuzhe Shi, Gertrude Gunset, Theodoros Giavridis, Michel Sadelain
Journal: Cancer Discovery
Cancer Discov (2024) 14 (1): 142–157.
https://doi.org/10.1158/2159-8290.CD-22-1319
Published: 12 January 2024
View article titled, Disruption of <em>SUV39H1</em>-Mediated H3K9 Methylation Sustains CAR T-cell Function
Open the PDF for Disruption of <em>SUV39H1</em>-Mediated H3K9 Methylation Sustains CAR T-cell Function in another window
Includes: Supplementary data
Journal Articles

GABA Regulates Electrical Activity and Tumor Initiation in Melanoma

Mohita Tagore, Emiliano Hergenreder, Sarah C. Perlee, Nelly M. Cruz, Laura Menocal, Shruthy Suresh, Eric Chan, Maayan Baron, Stephanie Melendez, Asim Dave, Walid K. Chatila, Jeremie Nsengimana, Richard P. Koche, Travis J. Hollmann, Trey Ideker, Lorenz Studer, Andrea Schietinger, Richard M. White
Journal: Cancer Discovery
Cancer Discov (2023) 13 (10): 2270–2291.
https://doi.org/10.1158/2159-8290.CD-23-0389
Published: 05 October 2023
View article titled, GABA Regulates Electrical Activity and Tumor Initiation in Melanoma
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Includes: Multimedia, Supplementary data
Journal Articles

PRC2-Inactivating Mutations in Cancer Enhance Cytotoxic Response to DNMT1-Targeted Therapy via Enhanced Viral Mimicry

Amish J. Patel, Sarah Warda, Jesper L.V. Maag, Rohan Misra, Miguel A. Miranda-Román, Mohini R. Pachai, Cindy J. Lee, Dan Li, Naitao Wang, Gabriella Bayshtok, Eve Fishinevich, Yinuo Meng, Elissa W.P. Wong, Juan Yan, Emily Giff, Melissa B. Pappalardi, Michael T. McCabe, Jonathan A. Fletcher, Charles M. Rudin, Sarat Chandarlapaty, Joseph M. Scandura, Richard P. Koche, Jacob L. Glass, Cristina R. Antonescu, Deyou Zheng, Yu Chen, Ping Chi
Journal: Cancer Discovery
Cancer Discov (2022) 12 (9): 2120–2139.
https://doi.org/10.1158/2159-8290.CD-21-1671
Published: 02 September 2022
View article titled, PRC2-Inactivating Mutations in Cancer Enhance Cytotoxic Response to DNMT1-Targeted Therapy via Enhanced Viral Mimicry
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Includes: Supplementary data
Journal Articles

Multiomic Analysis of Lung Tumors Defines Pathways Activated in Neuroendocrine Transformation

Alvaro Quintanal-Villalonga, Hirokazu Taniguchi, Yingqian A. Zhan, Maysun M. Hasan, Shweta S. Chavan, Fanli Meng, Fathema Uddin, Parvathy Manoj, Mark T.A. Donoghue, Helen H. Won, Joseph M. Chan, Metamia Ciampricotti, Andrew Chow, Michael Offin, Jason C. Chang, Jordana Ray-Kirton, Sam E. Tischfield, Jacklynn Egger, Umesh K. Bhanot, Irina Linkov, Marina Asher, Sonali Sinha, Joachim Silber, Christine A. Iacobuzio-Donahue, Michael H. Roehrl, Travis J. Hollmann, Helena A. Yu, Juan Qiu, Elisa de Stanchina, Marina K. Baine, Natasha Rekhtman, John T. Poirier, Brian Loomis, Richard P. Koche, Charles M. Rudin, Triparna Sen
Journal: Cancer Discovery
Cancer Discov (2021) 11 (12): 3028–3047.
https://doi.org/10.1158/2159-8290.CD-20-1863
Published: 02 December 2021
View article titled, Multiomic Analysis of Lung Tumors Defines Pathways Activated in Neuroendocrine Transformation
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Includes: Supplementary data
Journal Articles

LKB1/STK11 Is a Tumor Suppressor in the Progression of Myeloproliferative Neoplasms

Christian Marinaccio, Praveen Suraneni, Hamza Celik, Andrew Volk, Qiang Jeremy Wen, Te Ling, Marinka Bulic, Terra Lasho, Richard P. Koche, Christopher A. Famulare, Noushin Farnoud, Brady Stein, Michael Schieber, Sandeep Gurbuxani, David E. Root, Scott T. Younger, Ronald Hoffman, Naseema Gangat, Panagiotis Ntziachristos, Navdeep S. Chandel, Ross L. Levine, Raajit K. Rampal, Grant A. Challen, Ayalew Tefferi, John D. Crispino
Journal: Cancer Discovery
Cancer Discov (2021) 11 (6): 1398–1410.
https://doi.org/10.1158/2159-8290.CD-20-1353
Published: 01 June 2021
View article titled, LKB1/<em>STK11</em> Is a Tumor Suppressor in the Progression of Myeloproliferative Neoplasms
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Includes: Supplementary data
Journal Articles

SWI/SNF Complex Mutations Promote Thyroid Tumor Progression and Insensitivity to Redifferentiation Therapies

Mahesh Saqcena, Luis Javier Leandro-Garcia, Jesper L.V. Maag, Vatche Tchekmedyian, Gnana P. Krishnamoorthy, Prasanna P. Tamarapu, Vera Tiedje, Vincent Reuter, Jeffrey A. Knauf, Elisa de Stanchina, Bin Xu, Xiao-Hui Liao, Samuel Refetoff, Ronald Ghossein, Ping Chi, Alan L. Ho, Richard P. Koche, James A. Fagin
Journal: Cancer Discovery
Cancer Discov (2021) 11 (5): 1158–1175.
https://doi.org/10.1158/2159-8290.CD-20-0735
Published: 01 May 2021
View article titled, SWI/SNF Complex Mutations Promote Thyroid Tumor Progression and Insensitivity to Redifferentiation Therapies
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Includes: Supplementary data
Journal Articles

PRMT5 Inhibition Modulates E2F1 Methylation and Gene-Regulatory Networks Leading to Therapeutic Efficacy in JAK2V617F-Mutant MPN

Friederike Pastore, Neha Bhagwat, Alessandro Pastore, Aliaksandra Radzisheuskaya, Abdul Karzai, Aishwarya Krishnan, Bing Li, Robert L. Bowman, Wenbin Xiao, Aaron D. Viny, Anouar Zouak, Young C. Park, Keith B. Cordner, Stephanie Braunstein, Jesper L. Maag, Alexander Grego, Jaanvi Mehta, Min Wang, Hong Lin, Benjamin H. Durham, Richard P. Koche, Raajit K. Rampal, Kristian Helin, Peggy Scherle, Kris Vaddi, Ross L. Levine
Journal: Cancer Discovery
Cancer Discov (2020) 10 (11): 1742–1757.
https://doi.org/10.1158/2159-8290.CD-20-0026
Published: 02 November 2020
View article titled, PRMT5 Inhibition Modulates E2F1 Methylation and Gene-Regulatory Networks Leading to Therapeutic Efficacy in JAK2<sup>V617F</sup>-Mutant MPN
Open the PDF for PRMT5 Inhibition Modulates E2F1 Methylation and Gene-Regulatory Networks Leading to Therapeutic Efficacy in JAK2<sup>V617F</sup>-Mutant MPN in another window
Includes: Supplementary data
Journal Articles

Leukemia Cell of Origin Influences Apoptotic Priming and Sensitivity to LSD1 Inhibition

Sheng F. Cai, S. Haihua Chu, Aaron D. Goldberg, Salma Parvin, Richard P. Koche, Jacob L. Glass, Eytan M. Stein, Martin S. Tallman, Filiz Sen, Christopher A. Famulare, Monica Cusan, Chun-Hao Huang, Chun-Wei Chen, Lihua Zou, Keith B. Cordner, Nicole L. DelGaudio, Vidushi Durani, Mitali Kini, Madison Rex, Helen S. Tian, Johannes Zuber, Timour Baslan, Scott W. Lowe, Hugh Y. Rienhoff, Jr, Anthony Letai, Ross L. Levine, Scott A. Armstrong
Journal: Cancer Discovery
Cancer Discov (2020) 10 (10): 1500–1513.
https://doi.org/10.1158/2159-8290.CD-19-1469
Published: 01 October 2020
View article titled, Leukemia Cell of Origin Influences Apoptotic Priming and Sensitivity to LSD1 Inhibition
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Includes: Supplementary data
Journal Articles

A Gain-of-Function p53-Mutant Oncogene Promotes Cell Fate Plasticity and Myeloid Leukemia through the Pluripotency Factor FOXH1

Evangelia Loizou, Ana Banito, Geulah Livshits, Yu-Jui Ho, Richard P. Koche, Francisco J. Sánchez-Rivera, Allison Mayle, Chi-Chao Chen, Savvas Kinalis, Frederik O. Bagger, Edward R. Kastenhuber, Benjamin H. Durham, Scott W. Lowe
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2019) 9 (7): 962–979.
https://doi.org/10.1158/2159-8290.CD-18-1391
Published: 01 July 2019
View article titled, A Gain-of-Function p53-Mutant Oncogene Promotes Cell Fate Plasticity and Myeloid Leukemia through the Pluripotency Factor FOXH1
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Includes: Supplementary data
Journal Articles

MEF2C Phosphorylation Is Required for Chemotherapy Resistance in Acute Myeloid Leukemia

Fiona C. Brown, Eric Still, Richard P. Koche, Christina Y. Yim, Sumiko Takao, Paolo Cifani, Casie Reed, Shehana Gunasekera, Scott B. Ficarro, Peter Romanienko, Willie Mark, Craig McCarthy, Elisa de Stanchina, Mithat Gonen, Venkatraman Seshan, Patrick Bhola, Conor O'Donnell, Barbara Spitzer, Crystal Stutzke, Vincent-Philippe Lavallée, Josée Hébert, Andrei V. Krivtsov, Ari Melnick, Elisabeth M. Paietta, Martin S. Tallman, Anthony Letai, Guy Sauvageau, Gayle Pouliot, Ross Levine, Jarrod A Marto, Scott A. Armstrong, Alex Kentsis
Journal: Cancer Discovery
Cancer Discov (2018) 8 (4): 478–497.
https://doi.org/10.1158/2159-8290.CD-17-1271
Published: 01 April 2018
View article titled, MEF2C Phosphorylation Is Required for Chemotherapy Resistance in Acute Myeloid Leukemia
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Includes: Supplementary data
Journal Articles

FOXF1 Defines the Core-Regulatory Circuitry in Gastrointestinal Stromal Tumor

Leili Ran, Yuedan Chen, Jessica Sher, Elissa W.P. Wong, Devan Murphy, Jenny Q. Zhang, Dan Li, Kemal Deniz, Inna Sirota, Zhen Cao, Shangqian Wang, Youxin Guan, Shipra Shukla, Katie Yang Li, Alan Chramiec, Yuanyuan Xie, Deyou Zheng, Richard P. Koche, Cristina R. Antonescu, Yu Chen, Ping Chi
Journal: Cancer Discovery
Cancer Discov (2018) 8 (2): 234–251.
https://doi.org/10.1158/2159-8290.CD-17-0468
Published: 04 February 2018
View article titled, FOXF1 Defines the Core-Regulatory Circuitry in Gastrointestinal Stromal Tumor
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Includes: Supplementary data