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Journal Articles

PRC2-Inactivating Mutations in Cancer Enhance Cytotoxic Response to DNMT1-Targeted Therapy via Enhanced Viral Mimicry

Amish J. Patel, Sarah Warda, Jesper L.V. Maag, Rohan Misra, Miguel A. Miranda-Román, Mohini R. Pachai, Cindy J. Lee, Dan Li, Naitao Wang, Gabriella Bayshtok, Eve Fishinevich, Yinuo Meng, Elissa W.P. Wong, Juan Yan, Emily Giff, Melissa B. Pappalardi, Michael T. McCabe, Jonathan A. Fletcher, Charles M. Rudin, Sarat Chandarlapaty, Joseph M. Scandura, Richard P. Koche, Jacob L. Glass, Cristina R. Antonescu, Deyou Zheng, Yu Chen, Ping Chi
Journal: Cancer Discovery
Cancer Discov (2022) 12 (9): 2120–2139.
https://doi.org/10.1158/2159-8290.CD-21-1671
Published: 02 September 2022
View article titled, PRC2-Inactivating Mutations in Cancer Enhance Cytotoxic Response to DNMT1-Targeted Therapy via Enhanced Viral Mimicry
Open the PDF for PRC2-Inactivating Mutations in Cancer Enhance Cytotoxic Response to DNMT1-Targeted Therapy via Enhanced Viral Mimicry in another window
Includes: Supplementary data
Journal Articles

SWI/SNF Complex Mutations Promote Thyroid Tumor Progression and Insensitivity to Redifferentiation Therapies

Mahesh Saqcena, Luis Javier Leandro-Garcia, Jesper L.V. Maag, Vatche Tchekmedyian, Gnana P. Krishnamoorthy, Prasanna P. Tamarapu, Vera Tiedje, Vincent Reuter, Jeffrey A. Knauf, Elisa de Stanchina, Bin Xu, Xiao-Hui Liao, Samuel Refetoff, Ronald Ghossein, Ping Chi, Alan L. Ho, Richard P. Koche, James A. Fagin
Journal: Cancer Discovery
Cancer Discov (2021) 11 (5): 1158–1175.
https://doi.org/10.1158/2159-8290.CD-20-0735
Published: 01 May 2021
View article titled, SWI/SNF Complex Mutations Promote Thyroid Tumor Progression and Insensitivity to Redifferentiation Therapies
Open the PDF for SWI/SNF Complex Mutations Promote Thyroid Tumor Progression and Insensitivity to Redifferentiation Therapies in another window
Includes: Supplementary data
Journal Articles

FOXF1 Defines the Core-Regulatory Circuitry in Gastrointestinal Stromal Tumor

Leili Ran, Yuedan Chen, Jessica Sher, Elissa W.P. Wong, Devan Murphy, Jenny Q. Zhang, Dan Li, Kemal Deniz, Inna Sirota, Zhen Cao, Shangqian Wang, Youxin Guan, Shipra Shukla, Katie Yang Li, Alan Chramiec, Yuanyuan Xie, Deyou Zheng, Richard P. Koche, Cristina R. Antonescu, Yu Chen, Ping Chi
Journal: Cancer Discovery
Cancer Discov (2018) 8 (2): 234–251.
https://doi.org/10.1158/2159-8290.CD-17-0468
Published: 04 February 2018
View article titled, FOXF1 Defines the Core-Regulatory Circuitry in Gastrointestinal Stromal Tumor
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Includes: Supplementary data
Journal Articles

Combined Inhibition of MAP Kinase and KIT Signaling Synergistically Destabilizes ETV1 and Suppresses GIST Tumor Growth

Leili Ran, Inna Sirota, Zhen Cao, Devan Murphy, Yuedan Chen, Shipra Shukla, Yuanyuan Xie, Michael C. Kaufmann, Dong Gao, Sinan Zhu, Ferdinando Rossi, John Wongvipat, Takahiro Taguchi, William D. Tap, Ingo K. Mellinghoff, Peter Besmer, Cristina R. Antonescu, Yu Chen, Ping Chi
Journal: Cancer Discovery
Cancer Discov (2015) 5 (3): 304–315.
https://doi.org/10.1158/2159-8290.CD-14-0985
Published: 05 March 2015
View article titled, Combined Inhibition of MAP Kinase and KIT Signaling Synergistically Destabilizes ETV1 and Suppresses GIST Tumor Growth
Open the PDF for Combined Inhibition of MAP Kinase and KIT Signaling Synergistically Destabilizes ETV1 and Suppresses GIST Tumor Growth in another window
Includes: Supplementary data