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Peter Olson
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Journal Articles

Mechanisms of Resistance to Oncogenic KRAS Inhibition in Pancreatic Cancer

Julien Dilly, Megan T. Hoffman, Laleh Abbassi, Ziyue Li, Francesca Paradiso, Brendan D. Parent, Connor J. Hennessey, Alexander C. Jordan, Micaela Morgado, Shatavisha Dasgupta, Giselle A. Uribe, Annan Yang, Kevin S. Kapner, Felix P. Hambitzer, Li Qiang, Hanrong Feng, Jacob Geisberg, Junning Wang, Kyle E. Evans, Hengyu Lyu, Aislyn Schalck, Ningping Feng, Anastasia M. Lopez, Christopher A. Bristow, Michael P. Kim, Kimal I. Rajapakshe, Vahid Bahrambeigi, Jennifer A. Roth, Kavita Garg, Paola A. Guerrero, Ben Z. Stanger, Simona Cristea, Scott W. Lowe, Timour Baslan, Eliezer M. Van Allen, Joseph D. Mancias, Emily Chan, Abraham Anderson, Yuliya V. Katlinskaya, Alex K. Shalek, David S. Hong, Shubham Pant, Jill Hallin, Kenna Anderes, Peter Olson, Timothy P. Heffernan, Seema Chugh, James G. Christensen, Anirban Maitra, Brian M. Wolpin, Srivatsan Raghavan, Jonathan A. Nowak, Peter S. Winter, Stephanie K. Dougan, Andrew J. Aguirre
Journal: Cancer Discovery
Cancer Discov OF1–OF27.
https://doi.org/10.1158/2159-8290.CD-24-0177
Published: 03 October 2024
View article titled, Mechanisms of Resistance to Oncogenic KRAS Inhibition in Pancreatic Cancer
Open the PDF for Mechanisms of Resistance to Oncogenic KRAS Inhibition in Pancreatic Cancer in another window
Includes: Supplementary data
Journal Articles

MRTX1719 Is an MTA-Cooperative PRMT5 Inhibitor That Exhibits Synthetic Lethality in Preclinical Models and Patients with MTAP-Deleted Cancer

Lars D. Engstrom, Ruth Aranda, Laura Waters, Krystal Moya, Vickie Bowcut, Laura Vegar, David Trinh, Allan Hebbert, Christopher R. Smith, Svitlana Kulyk, J. David Lawson, Leo He, Laura D. Hover, Julio Fernandez-Banet, Jill Hallin, Darin Vanderpool, David M. Briere, Alice Blaj, Matthew A. Marx, Jordi Rodon, Michael Offin, Kathryn C. Arbour, Melissa L. Johnson, David J. Kwiatkowski, Pasi A. Jänne, Candace L. Haddox, Kyriakos P. Papadopoulos, Jason T. Henry, Konstantinos Leventakos, James G. Christensen, Ronald Shazer, Peter Olson
Journal: Cancer Discovery
Cancer Discov (2023) 13 (11): 2412–2431.
https://doi.org/10.1158/2159-8290.CD-23-0669
Published: 01 November 2023
View article titled, MRTX1719 Is an MTA-Cooperative PRMT5 Inhibitor That Exhibits Synthetic Lethality in Preclinical Models and Patients with <em>MTAP</em>-Deleted Cancer
Open the PDF for MRTX1719 Is an MTA-Cooperative PRMT5 Inhibitor That Exhibits Synthetic Lethality in Preclinical Models and Patients with <em>MTAP</em>-Deleted Cancer in another window
Includes: Supplementary data
Journal Articles

Combined Inhibition of SHP2 and CXCR1/2 Promotes Antitumor T-cell Response in NSCLC

Kwan Ho Tang, Shuai Li, Alireza Khodadadi-Jamayran, Jayu Jen, Han Han, Kayla Guidry, Ting Chen, Yuan Hao, Carmine Fedele, John A. Zebala, Dean Y. Maeda, James G. Christensen, Peter Olson, Argus Athanas, Cynthia A. Loomis, Aristotelis Tsirigos, Kwok-Kin Wong, Benjamin G. Neel
Journal: Cancer Discovery
Cancer Discov (2022) 12 (1): 47–61.
https://doi.org/10.1158/2159-8290.CD-21-0369
Published: 01 January 2022
View article titled, Combined Inhibition of SHP2 and CXCR1/2 Promotes Antitumor T-cell Response in NSCLC
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Includes: Supplementary data
Journal Articles

The KRASG12C Inhibitor MRTX849 Provides Insight toward Therapeutic Susceptibility of KRAS-Mutant Cancers in Mouse Models and Patients

Jill Hallin, Lars D. Engstrom, Lauren Hargis, Andrew Calinisan, Ruth Aranda, David M. Briere, Niranjan Sudhakar, Vickie Bowcut, Brian R. Baer, Joshua A. Ballard, Michael R. Burkard, Jay B. Fell, John P. Fischer, Guy P. Vigers, Yaohua Xue, Sole Gatto, Julio Fernandez-Banet, Adam Pavlicek, Karen Velastagui, Richard C. Chao, Jeremy Barton, Mariaelena Pierobon, Elisa Baldelli, Emanuel F. Patricoin, III, Douglas P. Cassidy, Matthew A. Marx, Igor I. Rybkin, Melissa L. Johnson, Sai-Hong Ignatius Ou, Piro Lito, Kyriakos P. Papadopoulos, Pasi A. Jänne, Peter Olson, James G. Christensen
Journal: Cancer Discovery
Cancer Discov (2020) 10 (1): 54–71.
https://doi.org/10.1158/2159-8290.CD-19-1167
Published: 09 January 2020
View article titled, The KRAS<sup>G12C</sup> Inhibitor MRTX849 Provides Insight toward Therapeutic Susceptibility of KRAS-Mutant Cancers in Mouse Models and Patients
Open the PDF for The KRAS<sup>G12C</sup> Inhibitor MRTX849 Provides Insight toward Therapeutic Susceptibility of KRAS-Mutant Cancers in Mouse Models and Patients in another window
Includes: Supplementary data
Journal Articles

Bruton Tyrosine Kinase–Dependent Immune Cell Cross-talk Drives Pancreas Cancer

Andrew J. Gunderson, Megan M. Kaneda, Takahiro Tsujikawa, Abraham V. Nguyen, Nesrine I. Affara, Brian Ruffell, Sara Gorjestani, Shannon M. Liudahl, Morgan Truitt, Peter Olson, Grace Kim, Douglas Hanahan, Margaret A. Tempero, Brett Sheppard, Bryan Irving, Betty Y. Chang, Judith A. Varner, Lisa M. Coussens
Journal: Cancer Discovery
Cancer Discov (2016) 6 (3): 270–285.
https://doi.org/10.1158/2159-8290.CD-15-0827
Published: 06 March 2016
View article titled, Bruton Tyrosine Kinase–Dependent Immune Cell Cross-talk Drives Pancreas Cancer
Open the PDF for Bruton Tyrosine Kinase–Dependent Immune Cell Cross-talk Drives Pancreas Cancer in another window
Includes: Supplementary data