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Patricia Greninger
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Journal Articles

EGFR Inhibition Potentiates FGFR Inhibitor Therapy and Overcomes Resistance in FGFR2 Fusion–Positive Cholangiocarcinoma

Qibiao Wu, Yuanli Zhen, Lei Shi, Phuong Vu, Patricia Greninger, Ramzi Adil, Joshua Merritt, Regina Egan, Meng-Ju Wu, Xunqin Yin, Cristina R. Ferrone, Vikram Deshpande, Islam Baiev, Christopher J. Pinto, Daniel E. McLoughlin, Charlotte S. Walmsley, James R. Stone, John D. Gordan, Andrew X. Zhu, Dejan Juric, Lipika Goyal, Cyril H. Benes, Nabeel Bardeesy
Journal: Cancer Discovery
Cancer Discov (2022) 12 (5): 1378–1395.
https://doi.org/10.1158/2159-8290.CD-21-1168
Published: 02 May 2022
View article titled, EGFR Inhibition Potentiates FGFR Inhibitor Therapy and Overcomes Resistance in FGFR2 Fusion–Positive Cholangiocarcinoma
Open the PDF for EGFR Inhibition Potentiates FGFR Inhibitor Therapy and Overcomes Resistance in FGFR2 Fusion–Positive Cholangiocarcinoma in another window
Includes: Supplementary data
Journal Articles

AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies

Sean Caenepeel, Sean P. Brown, Brian Belmontes, Gordon Moody, Kathleen S. Keegan, Danny Chui, Douglas A. Whittington, Xin Huang, Leszek Poppe, Alan C. Cheng, Mario Cardozo, Jonathan Houze, Yunxiao Li, Brian Lucas, Nick A. Paras, Xianghong Wang, Joshua P. Taygerly, Marc Vimolratana, Manuel Zancanella, Liusheng Zhu, Elaina Cajulis, Tao Osgood, Jan Sun, Leah Damon, Regina K. Egan, Patricia Greninger, Joseph D. McClanaghan, Jianan Gong, Donia Moujalled, Giovanna Pomilio, Pedro Beltran, Cyril H. Benes, Andrew W. Roberts, David C. Huang, Andrew Wei, Jude Canon, Angela Coxon, Paul E. Hughes
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2018) 8 (12): 1582–1597.
https://doi.org/10.1158/2159-8290.CD-18-0387
Published: 03 December 2018
View article titled, AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies
Open the PDF for AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies in another window
Includes: Multimedia, Supplementary data
Journal Articles

Isocitrate Dehydrogenase Mutations Confer Dasatinib Hypersensitivity and SRC Dependence in Intrahepatic Cholangiocarcinoma

Supriya K. Saha, John D. Gordan, Benjamin P. Kleinstiver, Phuong Vu, Mortada S. Najem, Jia-Chi Yeo, Lei Shi, Yasutaka Kato, Rebecca S. Levin, James T. Webber, Leah J. Damon, Regina K. Egan, Patricia Greninger, Ultan McDermott, Mathew J. Garnett, Roger L. Jenkins, Kimberly M. Rieger-Christ, Travis B. Sullivan, Aram F. Hezel, Andrew S. Liss, Yusuke Mizukami, Lipika Goyal, Cristina R. Ferrone, Andrew X. Zhu, J. Keith Joung, Kevan M. Shokat, Cyril H. Benes, Nabeel Bardeesy
Journal: Cancer Discovery
Cancer Discov (2016) 6 (7): 727–739.
https://doi.org/10.1158/2159-8290.CD-15-1442
Published: 30 June 2016
View article titled, Isocitrate Dehydrogenase Mutations Confer Dasatinib Hypersensitivity and SRC Dependence in Intrahepatic Cholangiocarcinoma
Open the PDF for Isocitrate Dehydrogenase Mutations Confer Dasatinib Hypersensitivity and SRC Dependence in Intrahepatic Cholangiocarcinoma in another window
Includes: Supplementary data
Journal Articles

A Coding Single-Nucleotide Polymorphism in Lysine Demethylase KDM4A Associates with Increased Sensitivity to mTOR Inhibitors

Capucine Van Rechem, Joshua C. Black, Patricia Greninger, Yang Zhao, Carlos Donado, Paul d. Burrowes, Brendon Ladd, David C. Christiani, Cyril H. Benes, Johnathan R. Whetstine
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2015) 5 (3): 245–254.
https://doi.org/10.1158/2159-8290.CD-14-1159
Published: 05 March 2015
View article titled, A Coding Single-Nucleotide Polymorphism in Lysine Demethylase <em>KDM4A</em> Associates with Increased Sensitivity to mTOR Inhibitors
Open the PDF for A Coding Single-Nucleotide Polymorphism in Lysine Demethylase <em>KDM4A</em> Associates with Increased Sensitivity to mTOR Inhibitors in another window
Includes: Supplementary data
Journal Articles

Targeting MYCN in Neuroblastoma by BET Bromodomain Inhibition

Alexandre Puissant, Stacey M. Frumm, Gabriela Alexe, Christopher F. Bassil, Jun Qi, Yvan H. Chanthery, Erin A. Nekritz, Rhamy Zeid, William Clay Gustafson, Patricia Greninger, Matthew J. Garnett, Ultan McDermott, Cyril H. Benes, Andrew L. Kung, William A. Weiss, James E. Bradner, Kimberly Stegmaier
Journal: Cancer Discovery
Cancer Discov (2013) 3 (3): 308–323.
https://doi.org/10.1158/2159-8290.CD-12-0418
Published: 07 March 2013
View article titled, Targeting MYCN in Neuroblastoma by BET Bromodomain Inhibition
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Includes: Supplementary data
Journal Articles

Mcl-1 and FBW7 Control a Dominant Survival Pathway Underlying HDAC and Bcl-2 Inhibitor Synergy in Squamous Cell Carcinoma

Lei He, Kristine Torres-Lockhart, Nicole Forster, Saranya Ramakrishnan, Patricia Greninger, Mathew J. Garnett, Ultan McDermott, Stephen M. Rothenberg, Cyril H. Benes, Leif W. Ellisen
Journal: Cancer Discovery
Cancer Discov (2013) 3 (3): 324–337.
https://doi.org/10.1158/2159-8290.CD-12-0417
Published: 07 March 2013
View article titled, Mcl-1 and FBW7 Control a Dominant Survival Pathway Underlying HDAC and Bcl-2 Inhibitor Synergy in Squamous Cell Carcinoma
Open the PDF for Mcl-1 and FBW7 Control a Dominant Survival Pathway Underlying HDAC and Bcl-2 Inhibitor Synergy in Squamous Cell Carcinoma in another window
Includes: Supplementary data