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Padmanee Sharma
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Journal Articles

The Next Decade of Immune Checkpoint Therapy

Padmanee Sharma, Bilal A. Siddiqui, Swetha Anandhan, Shalini S. Yadav, Sumit K. Subudhi, Jianjun Gao, Sangeeta Goswami, James P. Allison
Journal: Cancer Discovery
Cancer Discov (2021) 11 (4): 838–857.
https://doi.org/10.1158/2159-8290.CD-20-1680
Published: 01 April 2021
View article titled, The Next Decade of Immune Checkpoint Therapy
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Journal Articles

A Genetic Mouse Model Recapitulates Immune Checkpoint Inhibitor–Associated Myocarditis and Supports a Mechanism-Based Therapeutic Intervention

Spencer C. Wei, Wouter C. Meijers, Margaret L. Axelrod, Nana-Ama A.S. Anang, Elles M. Screever, Elizabeth C. Wescott, Douglas B. Johnson, Elizabeth Whitley, Lorenz Lehmann, Pierre-Yves Courand, James J. Mancuso, Lauren E. Himmel, Benedicte Lebrun-Vignes, Matthew J. Wleklinski, Bjorn C. Knollmann, Jayashree Srinivasan, Yu Li, Oluwatomisin T. Atolagbe, Xiayu Rao, Yang Zhao, Jing Wang, Lauren I.R. Ehrlich, Padmanee Sharma, Joe-Elie Salem, Justin M. Balko, Javid J. Moslehi, James P. Allison
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2021) 11 (3): 614–625.
https://doi.org/10.1158/2159-8290.CD-20-0856
Published: 02 March 2021
View article titled, A Genetic Mouse Model Recapitulates Immune Checkpoint Inhibitor–Associated Myocarditis and Supports a Mechanism-Based Therapeutic Intervention
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Includes: Supplementary data
Journal Articles

Efficacy, Safety, and Biomarkers of Response to Azacitidine and Nivolumab in Relapsed/Refractory Acute Myeloid Leukemia: A Nonrandomized, Open-Label, Phase II Study

Naval Daver, Guillermo Garcia-Manero, Sreyashi Basu, Prajwal C. Boddu, Mansour Alfayez, Jorge E. Cortes, Marina Konopleva, Farhad Ravandi-Kashani, Elias Jabbour, Tapan Kadia, Graciela M. Nogueras-Gonzalez, Jing Ning, Naveen Pemmaraju, Courtney D. DiNardo, Michael Andreeff, Sherry A. Pierce, Tauna Gordon, Steven M. Kornblau, Wilmer Flores, Zainab Alhamal, Carlos Bueso-Ramos, Jeffrey L. Jorgensen, Keyur P. Patel, Jorge Blando, James P. Allison, Padmanee Sharma, Hagop Kantarjian
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2019) 9 (3): 370–383.
https://doi.org/10.1158/2159-8290.CD-18-0774
Published: 01 March 2019
View article titled, Efficacy, Safety, and Biomarkers of Response to Azacitidine and Nivolumab in Relapsed/Refractory Acute Myeloid Leukemia: A Nonrandomized, Open-Label, Phase II Study
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Includes: Supplementary data
Journal Articles

TCR Repertoire Intratumor Heterogeneity in Localized Lung Adenocarcinomas: An Association with Predicted Neoantigen Heterogeneity and Postsurgical Recurrence

Alexandre Reuben, Rachel Gittelman, Jianjun Gao, Jiexin Zhang, Erik C. Yusko, Chang-Jiun Wu, Ryan Emerson, Jianhua Zhang, Christopher Tipton, Jun Li, Kelly Quek, Vancheswaran Gopalakrishnan, Runzhe Chen, Luis M. Vence, Tina Cascone, Marissa Vignali, Junya Fujimoto, Jaime Rodriguez-Canales, Edwin R. Parra, Latasha D. Little, Curtis Gumbs, Marie-Andrée Forget, Lorenzo Federico, Cara Haymaker, Carmen Behrens, Sharon Benzeno, Chantale Bernatchez, Boris Sepesi, Don L. Gibbons, Jennifer A. Wargo, William N. William, Jr, Stephen Swisher, John V. Heymach, Harlan Robins, J. Jack Lee, Padmanee Sharma, James P. Allison, P. Andrew Futreal, Ignacio I. Wistuba, Jianjun Zhang
Journal: Cancer Discovery
Cancer Discov (2017) 7 (10): 1088–1097.
https://doi.org/10.1158/2159-8290.CD-17-0256
Published: 02 October 2017
View article titled, TCR Repertoire Intratumor Heterogeneity in Localized Lung Adenocarcinomas: An Association with Predicted Neoantigen Heterogeneity and Postsurgical Recurrence
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Includes: Supplementary data
Journal Articles

Analysis of Immune Signatures in Longitudinal Tumor Samples Yields Insight into Biomarkers of Response and Mechanisms of Resistance to Immune Checkpoint Blockade

Pei-Ling Chen, Whijae Roh, Alexandre Reuben, Zachary A. Cooper, Christine N. Spencer, Peter A. Prieto, John P. Miller, Roland L. Bassett, Vancheswaran Gopalakrishnan, Khalida Wani, Mariana Petaccia De Macedo, Jacob L. Austin-Breneman, Hong Jiang, Qing Chang, Sangeetha M. Reddy, Wei-Shen Chen, Michael T. Tetzlaff, Russell J. Broaddus, Michael A. Davies, Jeffrey E. Gershenwald, Lauren Haydu, Alexander J. Lazar, Sapna P. Patel, Patrick Hwu, Wen-Jen Hwu, Adi Diab, Isabella C. Glitza, Scott E. Woodman, Luis M. Vence, Ignacio I. Wistuba, Rodabe N. Amaria, Lawrence N. Kwong, Victor Prieto, R. Eric Davis, Wencai Ma, Willem W. Overwijk, Arlene H. Sharpe, Jianhua Hu, P. Andrew Futreal, Jorge Blando, Padmanee Sharma, James P. Allison, Lynda Chin, Jennifer A. Wargo
Journal: Cancer Discovery
Cancer Discov (2016) 6 (8): 827–837.
https://doi.org/10.1158/2159-8290.CD-15-1545
Published: 01 August 2016
View article titled, Analysis of Immune Signatures in Longitudinal Tumor Samples Yields Insight into Biomarkers of Response and Mechanisms of Resistance to Immune Checkpoint Blockade
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Includes: Supplementary data
Journal Articles

Co-occurring Genomic Alterations Define Major Subsets of KRAS-Mutant Lung Adenocarcinoma with Distinct Biology, Immune Profiles, and Therapeutic Vulnerabilities

Ferdinandos Skoulidis, Lauren A. Byers, Lixia Diao, Vassiliki A. Papadimitrakopoulou, Pan Tong, Julie Izzo, Carmen Behrens, Humam Kadara, Edwin R. Parra, Jaime Rodriguez Canales, Jianjun Zhang, Uma Giri, Jayanthi Gudikote, Maria A. Cortez, Chao Yang, Youhong Fan, Michael Peyton, Luc Girard, Kevin R. Coombes, Carlo Toniatti, Timothy P. Heffernan, Murim Choi, Garrett M. Frampton, Vincent Miller, John N. Weinstein, Roy S. Herbst, Kwok-Kin Wong, Jianhua Zhang, Padmanee Sharma, Gordon B. Mills, Waun K. Hong, John D. Minna, James P. Allison, Andrew Futreal, Jing Wang, Ignacio I. Wistuba, John V. Heymach
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2015) 5 (8): 860–877.
https://doi.org/10.1158/2159-8290.CD-14-1236
Published: 03 August 2015
View article titled, Co-occurring Genomic Alterations Define Major Subsets of <em>KRAS</em>-Mutant Lung Adenocarcinoma with Distinct Biology, Immune Profiles, and Therapeutic Vulnerabilities
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Includes: Supplementary data
Journal Articles

Identification of Human Regulatory T Cells in the Setting of T-Cell Activation and Anti–CTLA-4 Immunotherapy on the Basis of Expression of Latency-Associated Peptide

Jingjing Sun, Derek Ng Tang, Tihui Fu, Padmanee Sharma
Journal: Cancer Discovery
Cancer Discov (2012) 2 (2): 122–130.
https://doi.org/10.1158/2159-8290.CD-11-0236
Published: 12 February 2012
View article titled, Identification of Human Regulatory T Cells in the Setting of T-Cell Activation and Anti–CTLA-4 Immunotherapy on the Basis of Expression of Latency-Associated Peptide
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