1-6 of 6
Ophélia Maertens
Close
Save search
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles

MAPK Pathway Suppression Unmasks Latent DNA Repair Defects and Confers a Chemical Synthetic Vulnerability in BRAF-, NRAS-, and NF1-Mutant Melanomas

Ophélia Maertens, Ryan Kuzmickas, Haley E. Manchester, Chloe E. Emerson, Alessandra G. Gavin, Caroline J. Guild, Terence C. Wong, Thomas De Raedt, Christian Bowman-Colin, Elodie Hatchi, Levi A. Garraway, Keith T. Flaherty, Shailja Pathania, Stephen J. Elledge, Karen Cichowski
Journal: Cancer Discovery
Cancer Discov (2019) 9 (4): 526–545.
https://doi.org/10.1158/2159-8290.CD-18-0879
Published: 01 April 2019
View article titled, MAPK Pathway Suppression Unmasks Latent DNA Repair Defects and Confers a Chemical Synthetic Vulnerability in <em>BRAF-, NRAS</em>-, and <em>NF1</em>-Mutant Melanomas
Open the PDF for MAPK Pathway Suppression Unmasks Latent DNA Repair Defects and Confers a Chemical Synthetic Vulnerability in <em>BRAF-, NRAS</em>-, and <em>NF1</em>-Mutant Melanomas in another window
Includes: Supplementary data
Journal Articles

mTOR and HDAC Inhibitors Converge on the TXNIP/Thioredoxin Pathway to Cause Catastrophic Oxidative Stress and Regression of RAS-Driven Tumors

Clare F. Malone, Chloe Emerson, Rachel Ingraham, William Barbosa, Stephanie Guerra, Haejin Yoon, Lin L. Liu, Franziska Michor, Marcia Haigis, Kay F. Macleod, Ophélia Maertens, Karen Cichowski
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2017) 7 (12): 1450–1463.
https://doi.org/10.1158/2159-8290.CD-17-0177
Published: 04 December 2017
View article titled, mTOR and HDAC Inhibitors Converge on the TXNIP/Thioredoxin Pathway to Cause Catastrophic Oxidative Stress and Regression of RAS-Driven Tumors
Open the PDF for mTOR and HDAC Inhibitors Converge on the TXNIP/Thioredoxin Pathway to Cause Catastrophic Oxidative Stress and Regression of RAS-Driven Tumors in another window
Includes: Supplementary data
Journal Articles

Defining Key Signaling Nodes and Therapeutic Biomarkers in NF1-Mutant Cancers

Clare F. Malone, Jody A. Fromm, Ophélia Maertens, Thomas DeRaedt, Rachel Ingraham, Karen Cichowski
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2014) 4 (9): 1062–1073.
https://doi.org/10.1158/2159-8290.CD-14-0159
Published: 01 September 2014
View article titled, Defining Key Signaling Nodes and Therapeutic Biomarkers in <em>NF1</em>-Mutant Cancers
Open the PDF for Defining Key Signaling Nodes and Therapeutic Biomarkers in <em>NF1</em>-Mutant Cancers in another window
Includes: Supplementary data
Journal Articles

Paths of Resistance to EGFR Inhibitors: Is NF Enough?

Ophélia Maertens, Karen Cichowski
Journal: Cancer Discovery
Cancer Discov (2014) 4 (5): 519–521.
https://doi.org/10.1158/2159-8290.CD-14-0286
Published: 01 May 2014
View article titled, Paths of Resistance to EGFR Inhibitors: Is NF Enough?
Open the PDF for Paths of Resistance to EGFR Inhibitors: Is NF Enough? in another window
Journal Articles

Elucidating Distinct Roles for NF1 in Melanomagenesis

Ophélia Maertens, Bryan Johnson, Pablo Hollstein, Dennie T. Frederick, Zachary A. Cooper, Ludwine Messiaen, Roderick T. Bronson, Martin McMahon, Scott Granter, Keith Flaherty, Jennifer A. Wargo, Richard Marais, Karen Cichowski
Journal: Cancer Discovery
Cancer Discov (2013) 3 (3): 338–349.
https://doi.org/10.1158/2159-8290.CD-12-0313
Published: 07 March 2013
View article titled, Elucidating Distinct Roles for <em>NF1</em> in Melanomagenesis
Open the PDF for Elucidating Distinct Roles for <em>NF1</em> in Melanomagenesis in another window
Includes: Supplementary data
Journal Articles

Reactivation of ERK Signaling Causes Resistance to EGFR Kinase Inhibitors

Dalia Ercan, Chunxiao Xu, Masahiko Yanagita, Calixte S. Monast, Christine A. Pratilas, Joan Montero, Mohit Butaney, Takeshi Shimamura, Lynette Sholl, Elena V. Ivanova, Madhavi Tadi, Andrew Rogers, Claire Repellin, Marzia Capelletti, Ophélia Maertens, Eva M. Goetz, Anthony Letai, Levi A. Garraway, Matthew J. Lazzara, Neal Rosen, Nathanael S. Gray, Kwok-Kin Wong, Pasi A. Jänne
Journal: Cancer Discovery
Cancer Discov (2012) 2 (10): 934–947.
https://doi.org/10.1158/2159-8290.CD-12-0103
Published: 14 October 2012
View article titled, Reactivation of ERK Signaling Causes Resistance to EGFR Kinase Inhibitors
Open the PDF for Reactivation of ERK Signaling Causes Resistance to EGFR Kinase Inhibitors in another window
Includes: Supplementary data