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Omar Abdel-Wahab
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Journal Articles

The Impact of Inflammation-Induced Tumor Plasticity during Myeloid Transformation

Anna Yeaton, Geraldine Cayanan, Sanam Loghavi, Igor Dolgalev, Emmett M. Leddin, Christian E. Loo, Hedieh Torabifard, Deedra Nicolet, Jingjing Wang, Kate Corrigan, Varvara Paraskevopoulou, Daniel T Starczynowski, Eric Wang, Omar Abdel-Wahab, Aaron D Viny, Richard M. Stone, John C. Byrd, Olga A. Guryanova, Rahul M. Kohli, G. Andrés Cisneros, Aristotelis Tsirigos, Ann-Kathrin Eisfeld, Iannis Aifantis, Maria Guillamot
Journal: Cancer Discovery
Cancer Discov (2022) 12 (10): 2392–2413.
https://doi.org/10.1158/2159-8290.CD-21-1146
Published: 05 October 2022
View article titled, The Impact of Inflammation-Induced Tumor Plasticity during Myeloid Transformation
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Includes: Supplementary data
Journal Articles

Impaired Proteolysis of Noncanonical RAS Proteins Drives Clonal Hematopoietic Transformation

Sisi Chen, Rahul S. Vedula, Antonio Cuevas-Navarro, Bin Lu, Simon J. Hogg, Eric Wang, Salima Benbarche, Katherine Knorr, Won Jun Kim, Robert F. Stanley, Hana Cho, Caroline Erickson, Michael Singer, Dan Cui, Steven Tittley, Benjamin H. Durham, Tatiana S. Pavletich, Elise Fiala, Michael F. Walsh, Daichi Inoue, Sebastien Monette, Justin Taylor, Neal Rosen, Frank McCormick, R. Coleman Lindsley, Pau Castel, Omar Abdel-Wahab
Journal: Cancer Discovery
Cancer Discov (2022) 12 (10): 2434–2453.
https://doi.org/10.1158/2159-8290.CD-21-1631
Published: 05 October 2022
View article titled, Impaired Proteolysis of Noncanonical RAS Proteins Drives Clonal Hematopoietic Transformation
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Includes: Supplementary data
Journal Articles

Sex-Biased ZRSR2 Mutations in Myeloid Malignancies Impair Plasmacytoid Dendritic Cell Activation and Apoptosis

Katsuhiro Togami, Sun Sook Chung, Vikas Madan, Christopher A.G. Booth, Christopher M. Kenyon, Lucia Cabal-Hierro, Justin Taylor, Sunhee S. Kim, Gabriel K. Griffin, Mahmoud Ghandi, Jia Li, Yvonne Y. Li, Fanny Angelot-Delettre, Sabeha Biichle, Michael Seiler, Silvia Buonamici, Scott B. Lovitch, Abner Louissaint, Jr, Elizabeth A. Morgan, Fabrice Jardin, Pier Paolo Piccaluga, David M. Weinstock, Peter S. Hammerman, Henry Yang, Marina Konopleva, Naveen Pemmaraju, Francine Garnache-Ottou, Omar Abdel-Wahab, H. Phillip Koeffler, Andrew A. Lane
Journal: Cancer Discovery
Cancer Discov (2022) 12 (2): 522–541.
https://doi.org/10.1158/2159-8290.CD-20-1513
Published: 01 February 2022
View article titled, Sex-Biased <em>ZRSR2</em> Mutations in Myeloid Malignancies Impair Plasmacytoid Dendritic Cell Activation and Apoptosis
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Includes: Supplementary data
Journal Articles

AXL Inhibition in Macrophages Stimulates Host-versus-Leukemia Immunity and Eradicates Naïve and Treatment-Resistant Leukemia

Irene Tirado-Gonzalez, Arnaud Descot, Devona Soetopo, Aleksandra Nevmerzhitskaya, Alexander Schäffer, Ivan-Maximilano Kur, Ewelina Czlonka, Carolin Wachtel, Ioanna Tsoukala, Luise Müller, Anna-Lena Schäfer, Maresa Weitmann, Petra Dinse, Emily Alberto, Michèle C. Buck, Jonathan JM. Landry, Bianka Baying, Julia Slotta-Huspenina, Jenny Roesler, Patrick N. Harter, Anne-Sophie Kubasch, Jörn Meinel, Eiman Elwakeel, Elisabeth Strack, Christine Tran Quang, Omar Abdel-Wahab, Marc Schmitz, Andreas Weigert, Tobias Schmid, Uwe Platzbecker, Vladimir Benes, Jacques Ghysdael, Halvard Bonig, Katharina S. Götze, Carla V. Rothlin, Sourav Ghosh, Hind Medyouf
Journal: Cancer Discovery
Cancer Discov (2021) 11 (11): 2924–2943.
https://doi.org/10.1158/2159-8290.CD-20-1378
Published: 01 November 2021
View article titled, AXL Inhibition in Macrophages Stimulates Host-versus-Leukemia Immunity and Eradicates Naïve and Treatment-Resistant Leukemia
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Includes: Supplementary data
Journal Articles

mRNA Export as a Novel Cancer-Specific Dependency

Eric Wang, Omar Abdel-Wahab
Journal: Cancer Discovery
Cancer Discov (2021) 11 (9): 2129–2131.
https://doi.org/10.1158/2159-8290.CD-21-0862
Published: 01 September 2021
View article titled, mRNA Export as a Novel Cancer-Specific Dependency
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Journal Articles

Mutations in the RNA Splicing Factor SF3B1 Promote Tumorigenesis through MYC Stabilization

Zhaoqi Liu, Akihide Yoshimi, Jiguang Wang, Hana Cho, Stanley Chun-Wei Lee, Michelle Ki, Lillian Bitner, Timothy Chu, Harshal Shah, Bo Liu, Anthony R. Mato, Peter Ruvolo, Giulia Fabbri, Laura Pasqualucci, Omar Abdel-Wahab, Raul Rabadan
Journal: Cancer Discovery
Cancer Discov (2020) 10 (6): 806–821.
https://doi.org/10.1158/2159-8290.CD-19-1330
Published: 01 June 2020
View article titled, Mutations in the RNA Splicing Factor SF3B1 Promote Tumorigenesis through MYC Stabilization
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Includes: Supplementary data
Journal Articles

Altered RNA Processing in Cancer Pathogenesis and Therapy

Esther A. Obeng, Connor Stewart, Omar Abdel-Wahab
Journal: Cancer Discovery
Cancer Discov (2019) 9 (11): 1493–1510.
https://doi.org/10.1158/2159-8290.CD-19-0399
Published: 01 November 2019
View article titled, Altered RNA Processing in Cancer Pathogenesis and Therapy
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Journal Articles

Altered Nuclear Export Signal Recognition as a Driver of Oncogenesis

Justin Taylor, Maria Sendino, Alexander N. Gorelick, Alessandro Pastore, Matthew T. Chang, Alexander V. Penson, Elena I. Gavrila, Connor Stewart, Ella M. Melnik, Florisela Herrejon Chavez, Lillian Bitner, Akihide Yoshimi, Stanley Chun-Wei Lee, Daichi Inoue, Bo Liu, Xiao J. Zhang, Anthony R. Mato, Ahmet Dogan, Michael G. Kharas, Yuhong Chen, Demin Wang, Rajesh K. Soni, Ronald C. Hendrickson, Gorka Prieto, Jose A. Rodriguez, Barry S. Taylor, Omar Abdel-Wahab
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2019) 9 (10): 1452–1467.
https://doi.org/10.1158/2159-8290.CD-19-0298
Published: 01 October 2019
View article titled, Altered Nuclear Export Signal Recognition as a Driver of Oncogenesis
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Includes: Supplementary data
Journal Articles

Rational Targeting of Cooperating Layers of the Epigenome Yields Enhanced Therapeutic Efficacy against AML

Cihangir Duy, Matt Teater, Francine E. Garrett-Bakelman, Tak C. Lee, Cem Meydan, Jacob L. Glass, Meng Li, Johannes C. Hellmuth, Helai P. Mohammad, Kimberly N. Smitheman, Alan H. Shih, Omar Abdel-Wahab, Martin S. Tallman, Monica L. Guzman, David Muench, H. Leighton Grimes, Gail J. Roboz, Ryan G. Kruger, Caretha L. Creasy, Elisabeth M. Paietta, Ross L. Levine, Martin Carroll, Ari M. Melnick
Journal: Cancer Discovery
Cancer Discov (2019) 9 (7): 872–889.
https://doi.org/10.1158/2159-8290.CD-19-0106
Published: 01 July 2019
View article titled, Rational Targeting of Cooperating Layers of the Epigenome Yields Enhanced Therapeutic Efficacy against AML
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Includes: Supplementary data
Journal Articles

Allele-Specific Mechanisms of Activation of MEK1 Mutants Determine Their Properties

Yijun Gao, Matthew T. Chang, Daniel McKay, Na Na, Bing Zhou, Rona Yaeger, Neilawattie M. Torres, Keven Muniz, Matthias Drosten, Mariano Barbacid, Giordano Caponigro, Darrin Stuart, Henrik Moebitz, David B. Solit, Omar Abdel-Wahab, Barry S. Taylor, Zhan Yao, Neal Rosen
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2018) 8 (5): 648–661.
https://doi.org/10.1158/2159-8290.CD-17-1452
Published: 30 April 2018
View article titled, Allele-Specific Mechanisms of Activation of MEK1 Mutants Determine Their Properties
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Includes: Supplementary data
Journal Articles

Diverse and Targetable Kinase Alterations Drive Histiocytic Neoplasms

Eli L. Diamond, Benjamin H. Durham, Julien Haroche, Zhan Yao, Jing Ma, Sameer A. Parikh, Zhaoming Wang, John Choi, Eunhee Kim, Fleur Cohen-Aubart, Stanley Chun-Wei Lee, Yijun Gao, Jean-Baptiste Micol, Patrick Campbell, Michael P. Walsh, Brooke Sylvester, Igor Dolgalev, Olga Aminova, Adriana Heguy, Paul Zappile, Joy Nakitandwe, Chezi Ganzel, James D. Dalton, David W. Ellison, Juvianee Estrada-Veras, Mario Lacouture, William A. Gahl, Philip J. Stephens, Vincent A. Miller, Jeffrey S. Ross, Siraj M. Ali, Samuel R. Briggs, Omotayo Fasan, Jared Block, Sebastien Héritier, Jean Donadieu, David B. Solit, David M. Hyman, José Baselga, Filip Janku, Barry S. Taylor, Christopher Y. Park, Zahir Amoura, Ahmet Dogan, Jean-Francois Emile, Neal Rosen, Tanja A. Gruber, Omar Abdel-Wahab
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2016) 6 (2): 154–165.
https://doi.org/10.1158/2159-8290.CD-15-0913
Published: 04 February 2016
View article titled, Diverse and Targetable Kinase Alterations Drive Histiocytic Neoplasms
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Includes: Supplementary data
Journal Articles

JAK–STAT Pathway Activation in Malignant and Nonmalignant Cells Contributes to MPN Pathogenesis and Therapeutic Response

Maria Kleppe, Minsuk Kwak, Priya Koppikar, Markus Riester, Matthew Keller, Lennart Bastian, Todd Hricik, Neha Bhagwat, Anna Sophia McKenney, Efthymia Papalexi, Omar Abdel-Wahab, Raajit Rampal, Sachie Marubayashi, Jonathan J. Chen, Vincent Romanet, Jordan S. Fridman, Jacqueline Bromberg, Julie Teruya-Feldstein, Masato Murakami, Thomas Radimerski, Franziska Michor, Rong Fan, Ross L. Levine
Journal: Cancer Discovery
Cancer Discov (2015) 5 (3): 316–331.
https://doi.org/10.1158/2159-8290.CD-14-0736
Published: 05 March 2015
View article titled, JAK–STAT Pathway Activation in Malignant and Nonmalignant Cells Contributes to MPN Pathogenesis and Therapeutic Response
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Includes: Supplementary data
Journal Articles

Prospective Blinded Study of BRAFV600E Mutation Detection in Cell-Free DNA of Patients with Systemic Histiocytic Disorders

David M. Hyman, Eli L. Diamond, Cecile Rose T. Vibat, Latifa Hassaine, Jason C. Poole, Minal Patel, Veronica R. Holley, Goran Cabrilo, Timothy T. Lu, Maria E. Arcila, Young Rock Chung, Raajit Rampal, Mario E. Lacouture, Neal Rosen, Funda Meric-Bernstam, José Baselga, Razelle Kurzrock, Mark G. Erlander, Filip Janku, Omar Abdel-Wahab
Journal: Cancer Discovery
Cancer Discov (2015) 5 (1): 64–71.
https://doi.org/10.1158/2159-8290.CD-14-0742
Published: 11 January 2015
View article titled, Prospective Blinded Study of <em>BRAF</em><sup>V600E</sup> Mutation Detection in Cell-Free DNA of Patients with Systemic Histiocytic Disorders
Open the PDF for Prospective Blinded Study of <em>BRAF</em><sup>V600E</sup> Mutation Detection in Cell-Free DNA of Patients with Systemic Histiocytic Disorders in another window
Includes: Supplementary data
Journal Articles

Efficacy of Intermittent Combined RAF and MEK Inhibition in a Patient with Concurrent BRAF- and NRAS-Mutant Malignancies

Omar Abdel-Wahab, Virginia M. Klimek, Alisa A. Gaskell, Agnes Viale, Donavan Cheng, Eunhee Kim, Raajit Rampal, Mark Bluth, James J. Harding, Margaret K. Callahan, Taha Merghoub, Michael F. Berger, David B. Solit, Neal Rosen, Ross L. Levine, Paul B. Chapman
Journal: Cancer Discovery
Cancer Discov (2014) 4 (5): 538–545.
https://doi.org/10.1158/2159-8290.CD-13-1038
Published: 01 May 2014
View article titled, Efficacy of Intermittent Combined RAF and MEK Inhibition in a Patient with Concurrent BRAF- and NRAS-Mutant Malignancies
Open the PDF for Efficacy of Intermittent Combined RAF and MEK Inhibition in a Patient with Concurrent BRAF- and NRAS-Mutant Malignancies in another window
Includes: Supplementary data