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Olivier Elemento
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Journal Articles

Noninvasive Detection of Neuroendocrine Prostate Cancer through Targeted Cell-free DNA Methylation

Gian Marco Franceschini, Orsetta Quaini, Kei Mizuno, Francesco Orlando, Yari Ciani, Sheng-Yu Ku, Michael Sigouros, Emily Rothmann, Alicia Alonso, Matteo Benelli, Caterina Nardella, Joonghoon Auh, Dory Freeman, Brian Hanratty, Mohamed Adil, Olivier Elemento, Scott T. Tagawa, Felix Y. Feng, Orazio Caffo, Consuelo Buttigliero, Umberto Basso, Peter S. Nelson, Eva Corey, Michael C. Haffner, Gerhardt Attard, Ana Aparicio, Francesca Demichelis, Himisha Beltran
Journal: Cancer Discovery
Cancer Discov (2024) 14 (3): 424–445.
https://doi.org/10.1158/2159-8290.CD-23-0754
Published: 01 March 2024
View article titled, Noninvasive Detection of Neuroendocrine Prostate Cancer through Targeted Cell-free DNA Methylation
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Includes: Supplementary data
Journal Articles

African Ancestry–Associated Gene Expression Profiles in Triple-Negative Breast Cancer Underlie Altered Tumor Biology and Clinical Outcome in Women of African Descent

Rachel Martini, Princesca Delpe, Timothy R. Chu, Kanika Arora, Brittany Lord, Akanksha Verma, Deepa Bedi, Balasubramanyam Karanam, Isra Elhussin, Yalei Chen, Endale Gebregzabher, Joseph K. Oppong, Ernest K. Adjei, Aisha Jibril Suleiman, Baffour Awuah, Mahteme Bekele Muleta, Engida Abebe, Ishmael Kyei, Frances S. Aitpillah, Michael O. Adinku, Kwasi Ankomah, Ernest Baawuah Osei-Bonsu, Dhananjay A. Chitale, Jessica M. Bensenhaver, David S. Nathanson, LaToya Jackson, Lindsay F. Petersen, Erica Proctor, Brian Stonaker, Kofi K. Gyan, Lee D. Gibbs, Zarko Monojlovic, Rick A. Kittles, Jason White, Clayton C. Yates, Upender Manne, Kevin Gardner, Nigel Mongan, Esther Cheng, Paula Ginter, Syed Hoda, Olivier Elemento, Nicolas Robine, Andrea Sboner, John D. Carpten, Lisa Newman, Melissa B. Davis
Journal: Cancer Discovery
Cancer Discov (2022) 12 (11): 2530–2551.
https://doi.org/10.1158/2159-8290.CD-22-0138
Published: 02 November 2022
View article titled, African Ancestry–Associated Gene Expression Profiles in Triple-Negative Breast Cancer Underlie Altered Tumor Biology and Clinical Outcome in Women of African Descent
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Includes: Supplementary data
Journal Articles

Discovery of Candidate DNA Methylation Cancer Driver Genes

Heng Pan, Loïc Renaud, Ronan Chaligne, Johannes Bloehdorn, Eugen Tausch, Daniel Mertens, Anna Maria Fink, Kirsten Fischer, Chao Zhang, Doron Betel, Andreas Gnirke, Marcin Imielinski, Jérôme Moreaux, Michael Hallek, Alexander Meissner, Stephan Stilgenbauer, Catherine J. Wu, Olivier Elemento, Dan A. Landau
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2021) 11 (9): 2266–2281.
https://doi.org/10.1158/2159-8290.CD-20-1334
Published: 01 September 2021
View article titled, Discovery of Candidate DNA Methylation Cancer Driver Genes
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Includes: Supplementary data
Journal Articles

Metastasis and Immune Evasion from Extracellular cGAMP Hydrolysis

Jun Li, Mercedes A. Duran, Ninjit Dhanota, Walid K. Chatila, Sarah E. Bettigole, John Kwon, Roshan K. Sriram, Matthew P. Humphries, Manuel Salto-Tellez, Jacqueline A. James, Matthew G. Hanna, Johannes C. Melms, Sreeram Vallabhaneni, Kevin Litchfield, Ieva Usaite, Dhruva Biswas, Rohan Bareja, Hao Wei Li, Maria Laura Martin, Princesca Dorsaint, Julie-Ann Cavallo, Peng Li, Chantal Pauli, Lee Gottesdiener, Benjamin J. DiPardo, Travis J. Hollmann, Taha Merghoub, Hannah Y. Wen, Jorge S. Reis-Filho, Nadeem Riaz, Shin-San Michael Su, Anusha Kalbasi, Neil Vasan, Simon N. Powell, Jedd D. Wolchok, Olivier Elemento, Charles Swanton, Alexander N. Shoushtari, Eileen E. Parkes, Benjamin Izar, Samuel F. Bakhoum
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2021) 11 (5): 1212–1227.
https://doi.org/10.1158/2159-8290.CD-20-0387
Published: 01 May 2021
View article titled, Metastasis and Immune Evasion from Extracellular cGAMP Hydrolysis
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Includes: Supplementary data
Journal Articles

Artificial Intelligence in Cancer Research and Precision Medicine

Bhavneet Bhinder, Coryandar Gilvary, Neel S. Madhukar, Olivier Elemento
Journal: Cancer Discovery
Cancer Discov (2021) 11 (4): 900–915.
https://doi.org/10.1158/2159-8290.CD-21-0090
Published: 01 April 2021
View article titled, Artificial Intelligence in Cancer Research and Precision Medicine
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Journal Articles

Lineage Reversion Drives WNT Independence in Intestinal Cancer

Teng Han, Sukanya Goswami, Yang Hu, Fanying Tang, Maria Paz Zafra, Charles Murphy, Zhen Cao, John T. Poirier, Ekta Khurana, Olivier Elemento, Jaclyn F. Hechtman, Karuna Ganesh, Rona Yaeger, Lukas E. Dow
Journal: Cancer Discovery
Cancer Discov (2020) 10 (10): 1590–1609.
https://doi.org/10.1158/2159-8290.CD-19-1536
Published: 01 October 2020
View article titled, Lineage Reversion Drives WNT Independence in Intestinal Cancer
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Includes: Supplementary data
Journal Articles

The INPP4B Tumor Suppressor Modulates EGFR Trafficking and Promotes Triple-Negative Breast Cancer

Hui Liu, Marcia N. Paddock, Haibin Wang, Charles J. Murphy, Renee C. Geck, Adrija J. Navarro, Gerburg M. Wulf, Olivier Elemento, Volker Haucke, Lewis C. Cantley, Alex Toker
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2020) 10 (8): 1226–1239.
https://doi.org/10.1158/2159-8290.CD-19-1262
Published: 03 August 2020
View article titled, The INPP4B Tumor Suppressor Modulates EGFR Trafficking and Promotes Triple-Negative Breast Cancer
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Includes: Supplementary data
Journal Articles

Tumor Microenvironment Is Critical for the Maintenance of Cellular States Found in Primary Glioblastomas

Allison R. Pine, Stefano M. Cirigliano, James G. Nicholson, Yang Hu, Amanda Linkous, Ken Miyaguchi, Lincoln Edwards, Richa Singhania, Theodore H. Schwartz, Rohan Ramakrishna, David J. Pisapia, Matija Snuderl, Olivier Elemento, Howard A. Fine
Journal: Cancer Discovery
Cancer Discov (2020) 10 (7): 964–979.
https://doi.org/10.1158/2159-8290.CD-20-0057
Published: 01 July 2020
View article titled, Tumor Microenvironment Is Critical for the Maintenance of Cellular States Found in Primary Glioblastomas
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Includes: Supplementary data
Journal Articles

A Recurrent Activating Missense Mutation in Waldenström Macroglobulinemia Affects the DNA Binding of the ETS Transcription Factor SPI1 and Enhances Proliferation

Damien Roos-Weil, Camille Decaudin, Marine Armand, Véronique Della-Valle, M'boyba K. Diop, Hussein Ghamlouch, Virginie Ropars, Cécile Hérate, Diane Lara, Eric Durot, Rima Haddad, Elena Mylonas, Frederik Damm, Francoise Pflumio, Bilyana Stoilova, Marlen Metzner, Olivier Elemento, Philippe Dessen, Valérie Camara-Clayette, François-Loïc Cosset, Els Verhoeyen, Véronique Leblond, Vincent Ribrag, Pascale Cornillet-Lefebvre, Philippe Rameau, Nabih Azar, Frédéric Charlotte, Pierre Morel, Jean-Baptiste Charbonnier, Paresh Vyas, Thomas Mercher, Said Aoufouchi, Nathalie Droin, Christel Guillouf, Florence Nguyen-Khac, Olivier A. Bernard
Journal: Cancer Discovery
Cancer Discov (2019) 9 (6): 796–811.
https://doi.org/10.1158/2159-8290.CD-18-0873
Published: 01 June 2019
View article titled, A Recurrent Activating Missense Mutation in Waldenström Macroglobulinemia Affects the DNA Binding of the ETS Transcription Factor SPI1 and Enhances Proliferation
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Includes: Supplementary data
Journal Articles

TET2 Deficiency Causes Germinal Center Hyperplasia, Impairs Plasma Cell Differentiation, and Promotes B-cell Lymphomagenesis

Pilar M. Dominguez, Hussein Ghamlouch, Wojciech Rosikiewicz, Parveen Kumar, Wendy Béguelin, Lorena Fontán, Martín A. Rivas, Patrycja Pawlikowska, Marine Armand, Enguerran Mouly, Miguel Torres-Martin, Ashley S. Doane, María T. Calvo Fernandez, Matt Durant, Veronique Della-Valle, Matt Teater, Luisa Cimmino, Nathalie Droin, Saber Tadros, Samaneh Motanagh, Alan H. Shih, Mark A. Rubin, Wayne Tam, Iannis Aifantis, Ross L. Levine, Olivier Elemento, Giorgio Inghirami, Michael R. Green, Maria E. Figueroa, Olivier A. Bernard, Said Aoufouchi, Sheng Li, Rita Shaknovich, Ari M. Melnick
Journal: Cancer Discovery
Cancer Discov (2018) 8 (12): 1632–1653.
https://doi.org/10.1158/2159-8290.CD-18-0657
Published: 03 December 2018
View article titled, TET2 Deficiency Causes Germinal Center Hyperplasia, Impairs Plasma Cell Differentiation, and Promotes B-cell Lymphomagenesis
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Includes: Supplementary data
Journal Articles

Identifying and Targeting Sporadic Oncogenic Genetic Aberrations in Mouse Models of Triple-Negative Breast Cancer

Hui Liu, Charles J. Murphy, Florian A. Karreth, Kristina B. Emdal, Forest M. White, Olivier Elemento, Alex Toker, Gerburg M. Wulf, Lewis C. Cantley
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2018) 8 (3): 354–369.
https://doi.org/10.1158/2159-8290.CD-17-0679
Published: 01 March 2018
View article titled, Identifying and Targeting Sporadic Oncogenic Genetic Aberrations in Mouse Models of Triple-Negative Breast Cancer
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Includes: Supplementary data
Journal Articles

Epigenetic Identity in AML Depends on Disruption of Nonpromoter Regulatory Elements and Is Affected by Antagonistic Effects of Mutations in Epigenetic Modifiers

Jacob L. Glass, Duane Hassane, Bas J. Wouters, Hiroyoshi Kunimoto, Roberto Avellino, Francine E. Garrett-Bakelman, Olga A. Guryanova, Robert Bowman, Shira Redlich, Andrew M. Intlekofer, Cem Meydan, Tingting Qin, Mame Fall, Alicia Alonso, Monica L. Guzman, Peter J.M. Valk, Craig B. Thompson, Ross Levine, Olivier Elemento, Ruud Delwel, Ari Melnick, Maria E. Figueroa
Journal: Cancer Discovery
Cancer Discov (2017) 7 (8): 868–883.
https://doi.org/10.1158/2159-8290.CD-16-1032
Published: 01 August 2017
View article titled, Epigenetic Identity in AML Depends on Disruption of Nonpromoter Regulatory Elements and Is Affected by Antagonistic Effects of Mutations in Epigenetic Modifiers
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Includes: Supplementary data
Journal Articles

Cabozantinib Eradicates Advanced Murine Prostate Cancer by Activating Antitumor Innate Immunity

Akash Patnaik, Kenneth D. Swanson, Eva Csizmadia, Aniruddh Solanki, Natalie Landon-Brace, Marina P. Gehring, Katja Helenius, Brian M. Olson, Athalia R. Pyzer, Lily C. Wang, Olivier Elemento, Jesse Novak, Thomas B. Thornley, John M. Asara, Laleh Montaser, Joshua J. Timmons, Todd M. Morgan, Yugang Wang, Elena Levantini, John G. Clohessy, Kathleen Kelly, Pier Paolo Pandolfi, Jacalyn M. Rosenblatt, David E. Avigan, Huihui Ye, Jeffrey M. Karp, Sabina Signoretti, Steven P. Balk, Lewis C. Cantley
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2017) 7 (7): 750–765.
https://doi.org/10.1158/2159-8290.CD-16-0778
Published: 05 July 2017
View article titled, Cabozantinib Eradicates Advanced Murine Prostate Cancer by Activating Antitumor Innate Immunity
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Includes: Supplementary data
Journal Articles

Personalized In Vitro and In Vivo Cancer Models to Guide Precision Medicine

Chantal Pauli, Benjamin D. Hopkins, Davide Prandi, Reid Shaw, Tarcisio Fedrizzi, Andrea Sboner, Verena Sailer, Michael Augello, Loredana Puca, Rachele Rosati, Terra J. McNary, Yelena Churakova, Cynthia Cheung, Joanna Triscott, David Pisapia, Rema Rao, Juan Miguel Mosquera, Brian Robinson, Bishoy M. Faltas, Brooke E. Emerling, Vijayakrishna K. Gadi, Brady Bernard, Olivier Elemento, Himisha Beltran, Francesca Demichelis, Christopher J. Kemp, Carla Grandori, Lewis C. Cantley, Mark A. Rubin
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2017) 7 (5): 462–477.
https://doi.org/10.1158/2159-8290.CD-16-1154
Published: 30 April 2017
View article titled, Personalized <em>In Vitro</em> and <em>In Vivo</em> Cancer Models to Guide Precision Medicine
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Includes: Supplementary data
Journal Articles

BCL6 Antagonizes NOTCH2 to Maintain Survival of Human Follicular Lymphoma Cells

Ester Valls, Camille Lobry, Huimin Geng, Ling Wang, Mariano Cardenas, Martín Rivas, Leandro Cerchietti, Philmo Oh, Shao Ning Yang, Erin Oswald, Camille W. Graham, Yanwen Jiang, Katerina Hatzi, Xabier Agirre, Eric Perkey, Zhuoning Li, Wayne Tam, Kamala Bhatt, John P. Leonard, Patrick A. Zweidler-McKay, Ivan Maillard, Olivier Elemento, Weimin Ci, Iannis Aifantis, Ari Melnick
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2017) 7 (5): 506–521.
https://doi.org/10.1158/2159-8290.CD-16-1189
Published: 30 April 2017
View article titled, BCL6 Antagonizes NOTCH2 to Maintain Survival of Human Follicular Lymphoma Cells
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Includes: Supplementary data
Journal Articles

CREBBP Inactivation Promotes the Development of HDAC3-Dependent Lymphomas

Yanwen Jiang, Ana Ortega-Molina, Huimin Geng, Hsia-Yuan Ying, Katerina Hatzi, Sara Parsa, Dylan McNally, Ling Wang, Ashley S. Doane, Xabier Agirre, Matt Teater, Cem Meydan, Zhuoning Li, David Poloway, Shenqiu Wang, Daisuke Ennishi, David W. Scott, Kristy R. Stengel, Janice E. Kranz, Edward Holson, Sneh Sharma, James W. Young, Chi-Shuen Chu, Robert G. Roeder, Rita Shaknovich, Scott W. Hiebert, Randy D. Gascoyne, Wayne Tam, Olivier Elemento, Hans-Guido Wendel, Ari M. Melnick
Journal: Cancer Discovery
Cancer Discov (2017) 7 (1): 38–53.
https://doi.org/10.1158/2159-8290.CD-16-0975
Published: 05 January 2017
View article titled, <em>CREBBP</em> Inactivation Promotes the Development of HDAC3-Dependent Lymphomas
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Includes: Supplementary data
Journal Articles

Cell-Cycle Reprogramming for PI3K Inhibition Overrides a Relapse-Specific C481S BTK Mutation Revealed by Longitudinal Functional Genomics in Mantle Cell Lymphoma

David Chiron, Maurizio Di Liberto, Peter Martin, Xiangao Huang, Jeff Sharman, Pedro Blecua, Susan Mathew, Priyanka Vijay, Ken Eng, Siraj Ali, Amy Johnson, Betty Chang, Scott Ely, Olivier Elemento, Christopher E. Mason, John P. Leonard, Selina Chen-Kiang
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2014) 4 (9): 1022–1035.
https://doi.org/10.1158/2159-8290.CD-14-0098
Published: 01 September 2014
View article titled, Cell-Cycle Reprogramming for PI3K Inhibition Overrides a Relapse-Specific C481S <em>BTK</em> Mutation Revealed by Longitudinal Functional Genomics in Mantle Cell Lymphoma
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Includes: Supplementary data
Journal Articles

Tracing the Roots of Cancer Evolution

Yanwen Jiang, Olivier Elemento
Journal: Cancer Discovery
Cancer Discov (2014) 4 (9): 995–997.
https://doi.org/10.1158/2159-8290.CD-14-0743
Published: 01 September 2014
View article titled, Tracing the Roots of Cancer Evolution
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Journal Articles

Integrative Epigenomic Analysis Identifies Biomarkers and Therapeutic Targets in Adult B-Acute Lymphoblastic Leukemia

Huimin Geng, Sarah Brennan, Thomas A. Milne, Wei-Yi Chen, Yushan Li, Christian Hurtz, Soo-Mi Kweon, Lynette Zickl, Seyedmehdi Shojaee, Donna Neuberg, Chuanxin Huang, Debabrata Biswas, Yuan Xin, Janis Racevskis, Rhett P. Ketterling, Selina M. Luger, Hillard Lazarus, Martin S. Tallman, Jacob M. Rowe, Mark R. Litzow, Monica L. Guzman, C. David Allis, Robert G. Roeder, Markus Müschen, Elisabeth Paietta, Olivier Elemento, Ari M. Melnick
Journal: Cancer Discovery
Cancer Discov (2012) 2 (11): 1004–1023.
https://doi.org/10.1158/2159-8290.CD-12-0208
Published: 11 November 2012
View article titled, Integrative Epigenomic Analysis Identifies Biomarkers and Therapeutic Targets in Adult B-Acute Lymphoblastic Leukemia
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Includes: Supplementary data