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Nikhil Wagle
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Journal Articles

The Genomic Landscape of Intrinsic and Acquired Resistance to Cyclin-Dependent Kinase 4/6 Inhibitors in Patients with Hormone Receptor–Positive Metastatic Breast Cancer

Seth A. Wander, Ofir Cohen, Xueqian Gong, Gabriela N. Johnson, Jorge E. Buendia-Buendia, Maxwell R. Lloyd, Dewey Kim, Flora Luo, Pingping Mao, Karla Helvie, Kailey J. Kowalski, Utthara Nayar, Adrienne G. Waks, Stephen H. Parsons, Ricardo Martinez, Lacey M. Litchfield, Xiang S. Ye, Chunping Yu, Valerie M. Jansen, John R. Stille, Patricia S. Smith, Gerard J. Oakley, Quincy S. Chu, Gerald Batist, Melissa E. Hughes, Jill D. Kremer, Levi A. Garraway, Eric P. Winer, Sara M. Tolaney, Nancy U. Lin, Sean G. Buchanan, Nikhil Wagle
Journal: Cancer Discovery
Cancer Discov (2020) 10 (8): 1174–1193.
https://doi.org/10.1158/2159-8290.CD-19-1390
Published: 03 August 2020
View article titled, The Genomic Landscape of Intrinsic and Acquired Resistance to Cyclin-Dependent Kinase 4/6 Inhibitors in Patients with Hormone Receptor–Positive Metastatic Breast Cancer
Open the PDF for The Genomic Landscape of Intrinsic and Acquired Resistance to Cyclin-Dependent Kinase 4/6 Inhibitors in Patients with Hormone Receptor–Positive Metastatic Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Real-time Genomic Characterization of Advanced Pancreatic Cancer to Enable Precision Medicine

Andrew J. Aguirre, Jonathan A. Nowak, Nicholas D. Camarda, Richard A. Moffitt, Arezou A. Ghazani, Mehlika Hazar-Rethinam, Srivatsan Raghavan, Jaegil Kim, Lauren K. Brais, Dorisanne Ragon, Marisa W. Welch, Emma Reilly, Devin McCabe, Lori Marini, Kristin Anderka, Karla Helvie, Nelly Oliver, Ana Babic, Annacarolina Da Silva, Brandon Nadres, Emily E. Van Seventer, Heather A. Shahzade, Joseph P. St. Pierre, Kelly P. Burke, Thomas Clancy, James M. Cleary, Leona A. Doyle, Kunal Jajoo, Nadine J. McCleary, Jeffrey A. Meyerhardt, Janet E. Murphy, Kimmie Ng, Anuj K. Patel, Kimberly Perez, Michael H. Rosenthal, Douglas A. Rubinson, Marvin Ryou, Geoffrey I. Shapiro, Ewa Sicinska, Stuart G. Silverman, Rebecca J. Nagy, Richard B. Lanman, Deborah Knoerzer, Dean J. Welsch, Matthew B. Yurgelun, Charles S. Fuchs, Levi A. Garraway, Gad Getz, Jason L. Hornick, Bruce E. Johnson, Matthew H. Kulke, Robert J. Mayer, Jeffrey W. Miller, Paul B. Shyn, David A. Tuveson, Nikhil Wagle, Jen Jen Yeh, William C. Hahn, Ryan B. Corcoran, Scott L. Carter, Brian M. Wolpin
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2018) 8 (9): 1096–1111.
https://doi.org/10.1158/2159-8290.CD-18-0275
Published: 04 September 2018
View article titled, Real-time Genomic Characterization of Advanced Pancreatic Cancer to Enable Precision Medicine
Open the PDF for Real-time Genomic Characterization of Advanced Pancreatic Cancer to Enable Precision Medicine in another window
Includes: Supplementary data
Journal Articles

Clinical Acquired Resistance to RAF Inhibitor Combinations in BRAF-Mutant Colorectal Cancer through MAPK Pathway Alterations

Leanne G. Ahronian, Erin M. Sennott, Eliezer M. Van Allen, Nikhil Wagle, Eunice L. Kwak, Jason E. Faris, Jason T. Godfrey, Koki Nishimura, Kerry D. Lynch, Craig H. Mermel, Elizabeth L. Lockerman, Anuj Kalsy, Joseph M. Gurski, Jr, Samira Bahl, Kristin Anderka, Lisa M. Green, Niall J. Lennon, Tiffany G. Huynh, Mari Mino-Kenudson, Gad Getz, Dora Dias-Santagata, A. John Iafrate, Jeffrey A. Engelman, Levi A. Garraway, Ryan B. Corcoran
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2015) 5 (4): 358–367.
https://doi.org/10.1158/2159-8290.CD-14-1518
Published: 05 April 2015
View article titled, Clinical Acquired Resistance to RAF Inhibitor Combinations in <em>BRAF</em>-Mutant Colorectal Cancer through MAPK Pathway Alterations
Open the PDF for Clinical Acquired Resistance to RAF Inhibitor Combinations in <em>BRAF</em>-Mutant Colorectal Cancer through MAPK Pathway Alterations in another window
Includes: Supplementary data
Journal Articles

Somatic ERCC2 Mutations Correlate with Cisplatin Sensitivity in Muscle-Invasive Urothelial Carcinoma

Eliezer M. Van Allen, Kent W. Mouw, Philip Kim, Gopa Iyer, Nikhil Wagle, Hikmat Al-Ahmadie, Cong Zhu, Irina Ostrovnaya, Gregory V. Kryukov, Kevin W. O'Connor, John Sfakianos, Ilana Garcia-Grossman, Jaegil Kim, Elizabeth A. Guancial, Richard Bambury, Samira Bahl, Namrata Gupta, Deborah Farlow, Angela Qu, Sabina Signoretti, Justine A. Barletta, Victor Reuter, Jesse Boehm, Michael Lawrence, Gad Getz, Philip Kantoff, Bernard H. Bochner, Toni K. Choueiri, Dean F. Bajorin, David B. Solit, Stacey Gabriel, Alan D'Andrea, Levi A. Garraway, Jonathan E. Rosenberg
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2014) 4 (10): 1140–1153.
https://doi.org/10.1158/2159-8290.CD-14-0623
Published: 30 September 2014
View article titled, Somatic <em>ERCC2</em> Mutations Correlate with Cisplatin Sensitivity in Muscle-Invasive Urothelial Carcinoma
Open the PDF for Somatic <em>ERCC2</em> Mutations Correlate with Cisplatin Sensitivity in Muscle-Invasive Urothelial Carcinoma in another window
Includes: Supplementary data
Journal Articles

Activating mTOR Mutations in a Patient with an Extraordinary Response on a Phase I Trial of Everolimus and Pazopanib

Nikhil Wagle, Brian C. Grabiner, Eliezer M. Van Allen, Eran Hodis, Susanna Jacobus, Jeffrey G. Supko, Michelle Stewart, Toni K. Choueiri, Leena Gandhi, James M. Cleary, Aymen A. Elfiky, Mary Ellen Taplin, Edward C. Stack, Sabina Signoretti, Massimo Loda, Geoffrey I. Shapiro, David M. Sabatini, Eric S. Lander, Stacey B. Gabriel, Philip W. Kantoff, Levi A. Garraway, Jonathan E. Rosenberg
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2014) 4 (5): 546–553.
https://doi.org/10.1158/2159-8290.CD-13-0353
Published: 01 May 2014
View article titled, Activating mTOR Mutations in a Patient with an Extraordinary Response on a Phase I Trial of Everolimus and Pazopanib
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Includes: Supplementary data
Journal Articles

The Genetic Landscape of Clinical Resistance to RAF Inhibition in Metastatic Melanoma

Eliezer M. Van Allen, Nikhil Wagle, Antje Sucker, Daniel J. Treacy, Cory M. Johannessen, Eva M. Goetz, Chelsea S. Place, Amaro Taylor-Weiner, Steven Whittaker, Gregory V. Kryukov, Eran Hodis, Mara Rosenberg, Aaron McKenna, Kristian Cibulskis, Deborah Farlow, Lisa Zimmer, Uwe Hillen, Ralf Gutzmer, Simone M. Goldinger, Selma Ugurel, Helen J. Gogas, Friederike Egberts, Carola Berking, Uwe Trefzer, Carmen Loquai, Benjamin Weide, Jessica C. Hassel, Stacey B. Gabriel, Scott L. Carter, Gad Getz, Levi A. Garraway, Dirk Schadendorf
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2014) 4 (1): 94–109.
https://doi.org/10.1158/2159-8290.CD-13-0617
Published: 07 January 2014
View article titled, The Genetic Landscape of Clinical Resistance to RAF Inhibition in Metastatic Melanoma
Open the PDF for The Genetic Landscape of Clinical Resistance to RAF Inhibition in Metastatic Melanoma in another window
Includes: Supplementary data
Journal Articles

MAP Kinase Pathway Alterations in BRAF-Mutant Melanoma Patients with Acquired Resistance to Combined RAF/MEK Inhibition

Nikhil Wagle, Eliezer M. Van Allen, Daniel J. Treacy, Dennie T. Frederick, Zachary A. Cooper, Amaro Taylor-Weiner, Mara Rosenberg, Eva M. Goetz, Ryan J. Sullivan, Deborah N. Farlow, Dennis C. Friedrich, Kristin Anderka, Danielle Perrin, Cory M. Johannessen, Aaron McKenna, Kristian Cibulskis, Gregory Kryukov, Eran Hodis, Donald P. Lawrence, Sheila Fisher, Gad Getz, Stacey B. Gabriel, Scott L. Carter, Keith T. Flaherty, Jennifer A. Wargo, Levi A. Garraway
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2014) 4 (1): 61–68.
https://doi.org/10.1158/2159-8290.CD-13-0631
Published: 07 January 2014
View article titled, MAP Kinase Pathway Alterations in <em>BRAF</em>-Mutant Melanoma Patients with Acquired Resistance to Combined RAF/MEK Inhibition
Open the PDF for MAP Kinase Pathway Alterations in <em>BRAF</em>-Mutant Melanoma Patients with Acquired Resistance to Combined RAF/MEK Inhibition in another window
Includes: Supplementary data
Journal Articles

A Genome-Scale RNA Interference Screen Implicates NF1 Loss in Resistance to RAF Inhibition

Steven R. Whittaker, Jean-Philippe Theurillat, Eliezer Van Allen, Nikhil Wagle, Jessica Hsiao, Glenn S. Cowley, Dirk Schadendorf, David E. Root, Levi A. Garraway
Journal: Cancer Discovery
Cancer Discov (2013) 3 (3): 350–362.
https://doi.org/10.1158/2159-8290.CD-12-0470
Published: 07 March 2013
View article titled, A Genome-Scale RNA Interference Screen Implicates NF1 Loss in Resistance to RAF Inhibition
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Includes: Supplementary data
Journal Articles

High-Throughput Detection of Actionable Genomic Alterations in Clinical Tumor Samples by Targeted, Massively Parallel Sequencing

Nikhil Wagle, Michael F. Berger, Matthew J. Davis, Brendan Blumenstiel, Matthew DeFelice, Panisa Pochanard, Matthew Ducar, Paul Van Hummelen, Laura E. MacConaill, William C. Hahn, Matthew Meyerson, Stacey B. Gabriel, Levi A. Garraway
Journal: Cancer Discovery
Cancer Discov (2012) 2 (1): 82–93.
https://doi.org/10.1158/2159-8290.CD-11-0184
Published: 12 January 2012
View article titled, High-Throughput Detection of Actionable Genomic Alterations in Clinical Tumor Samples by Targeted, Massively Parallel Sequencing
Open the PDF for High-Throughput Detection of Actionable Genomic Alterations in Clinical Tumor Samples by Targeted, Massively Parallel Sequencing in another window
Includes: Supplementary data