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Nicola Valeri
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Journal Articles

MNK Inhibition Sensitizes KRAS-Mutant Colorectal Cancer to mTORC1 Inhibition by Reducing eIF4E Phosphorylation and c-MYC Expression

Free
John R.P. Knight, Constantinos Alexandrou, George L. Skalka, Nikola Vlahov, Kathryn Pennel, Leah Officer, Ana Teodosio, Georgios Kanellos, David M. Gay, Sebastian May-Wilson, Ewan M. Smith, Arafath K. Najumudeen, Kathryn Gilroy, Rachel A. Ridgway, Dustin J. Flanagan, Rachael C.L. Smith, Laura McDonald, Craig MacKay, Anne Cheasty, Kerri McArthur, Emma Stanway, Joshua D. Leach, Rene Jackstadt, Joseph A. Waldron, Andrew D. Campbell, Georgios Vlachogiannis, Nicola Valeri, Kevin M. Haigis, Nahum Sonenberg, Christopher G. Proud, Neil P. Jones, Martin E. Swarbrick, Heather J. McKinnon, William J. Faller, John Le Quesne, Joanne Edwards, Anne E. Willis, Martin Bushell, Owen J. Sansom
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2021) 11 (5): 1228–1247.
https://doi.org/10.1158/2159-8290.CD-20-0652
Published: 01 May 2021
View articletitled, MNK Inhibition Sensitizes KRAS-Mutant Colorectal Cancer to mTORC1 Inhibition by Reducing eIF4E Phosphorylation and c-MYC Expression
Open the PDF for MNK Inhibition Sensitizes KRAS-Mutant Colorectal Cancer to mTORC1 Inhibition by Reducing eIF4E Phosphorylation and c-MYC Expression in another window
Includes: Supplementary data
Journal Articles

EGFR Blockade Reverts Resistance to KRASG12C Inhibition in Colorectal Cancer

Available to Purchase
Vito Amodio, Rona Yaeger, Pamela Arcella, Carlotta Cancelliere, Simona Lamba, Annalisa Lorenzato, Sabrina Arena, Monica Montone, Benedetta Mussolin, Yu Bian, Adele Whaley, Marika Pinnelli, Yonina R. Murciano-Goroff, Efsevia Vakiani, Nicola Valeri, Wei-Li Liao, Anuja Bhalkikar, Sheeno Thyparambil, Hui-Yong Zhao, Elisa de Stanchina, Silvia Marsoni, Salvatore Siena, Andrea Bertotti, Livio Trusolino, Bob T. Li, Neal Rosen, Federica Di Nicolantonio, Alberto Bardelli, Sandra Misale
Journal: Cancer Discovery
Cancer Discov (2020) 10 (8): 1129–1139.
https://doi.org/10.1158/2159-8290.CD-20-0187
Published: 03 August 2020
View articletitled, EGFR Blockade Reverts Resistance to KRASG12C Inhibition in Colorectal Cancer
Open the PDF for EGFR Blockade Reverts Resistance to KRASG12C Inhibition in Colorectal Cancer in another window
Includes: Supplementary data
Journal Articles

Longitudinal Liquid Biopsy and Mathematical Modeling of Clonal Evolution Forecast Time to Treatment Failure in the PROSPECT-C Phase II Colorectal Cancer Clinical Trial

Free
Khurum H. Khan, David Cunningham, Benjamin Werner, Georgios Vlachogiannis, Inmaculada Spiteri, Timon Heide, Javier Fernandez Mateos, Alexandra Vatsiou, Andrea Lampis, Mahnaz Darvish Damavandi, Hazel Lote, Ian Said Huntingford, Somaieh Hedayat, Ian Chau, Nina Tunariu, Giulia Mentrasti, Francesco Trevisani, Sheela Rao, Gayathri Anandappa, David Watkins, Naureen Starling, Janet Thomas, Clare Peckitt, Nasir Khan, Massimo Rugge, Ruwaida Begum, Blanka Hezelova, Annette Bryant, Thomas Jones, Paula Proszek, Matteo Fassan, Jens C. Hahne, Michael Hubank, Chiara Braconi, Andrea Sottoriva, Nicola Valeri
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2018) 8 (10): 1270–1285.
https://doi.org/10.1158/2159-8290.CD-17-0891
Published: 02 October 2018
View articletitled, Longitudinal Liquid Biopsy and Mathematical Modeling of Clonal Evolution Forecast Time to Treatment Failure in the PROSPECT-C Phase II Colorectal Cancer Clinical Trial
Open the PDF for Longitudinal Liquid Biopsy and Mathematical Modeling of Clonal Evolution Forecast Time to Treatment Failure in the PROSPECT-C Phase II Colorectal Cancer Clinical Trial in another window
Includes: Supplementary data