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Nicholas McGranahan
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Journal Articles

Spatial Architecture of Myeloid and T Cells Orchestrates Immune Evasion and Clinical Outcome in Lung Cancer

Katey S.S. Enfield, Emma Colliver, Claudia Lee, Alastair Magness, David A. Moore, Monica Sivakumar, Kristiana Grigoriadis, Oriol Pich, Takahiro Karasaki, Philip S. Hobson, Dina Levi, Selvaraju Veeriah, Clare Puttick, Emma L. Nye, Mary Green, Krijn K. Dijkstra, Masako Shimato, Ayse U. Akarca, Teresa Marafioti, Roberto Salgado, Allan Hackshaw, TRACERx consortium, Mariam Jamal-Hanjani, Febe van Maldegem, Nicholas McGranahan, Benjamin Glass, Hanna Pulaski, Eric Walk, James L. Reading, Sergio A. Quezada, Crispin T. Hiley, Julian Downward, Erik Sahai, Charles Swanton, Mihaela Angelova
Journal: Cancer Discovery
Cancer Discov (2024) 14 (6): 1018–1047.
https://doi.org/10.1158/2159-8290.CD-23-1380
Published: 03 June 2024
View article titled, Spatial Architecture of Myeloid and T Cells Orchestrates Immune Evasion and Clinical Outcome in Lung Cancer
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Includes: Supplementary data
Journal Articles

Late-Stage Metastatic Melanoma Emerges through a Diversity of Evolutionary Pathways

Lavinia Spain, Alexander Coulton, Irene Lobon, Andrew Rowan, Desiree Schnidrig, Scott T.C. Shepherd, Benjamin Shum, Fiona Byrne, Maria Goicoechea, Elisa Piperni, Lewis Au, Kim Edmonds, Eleanor Carlyle, Nikki Hunter, Alexandra Renn, Christina Messiou, Peta Hughes, Jaime Nobbs, Floris Foijer, Hilda van den Bos, Rene Wardenaar, Diana C.J. Spierings, Charlotte Spencer, Andreas M. Schmitt, Zayd Tippu, Karla Lingard, Lauren Grostate, Kema Peat, Kayleigh Kelly, Sarah Sarker, Sarah Vaughan, Mary Mangwende, Lauren Terry, Denise Kelly, Jennifer Biano, Aida Murra, Justine Korteweg, Charlotte Lewis, Molly O'Flaherty, Anne-Laure Cattin, Max Emmerich, Camille L. Gerard, Husayn Ahmed Pallikonda, Joanna Lynch, Robert Mason, Aljosja Rogiers, Hang Xu, Ariana Huebner, Nicholas McGranahan, Maise Al Bakir, Jun Murai, Cristina Naceur-Lombardelli, Elaine Borg, Miriam Mitchison, David A. Moore, Mary Falzon, Ian Proctor, Gordon W.H. Stamp, Emma L. Nye, Kate Young, Andrew J.S. Furness, Lisa Pickering, Ruby Stewart, Ula Mahadeva, Anna Green, James Larkin, Kevin Litchfield, Charles Swanton, Mariam Jamal-Hanjani, for the PEACE Consortium, Samra Turajlic
Journal: Cancer Discovery
Cancer Discov (2023) 13 (6): 1364–1385.
https://doi.org/10.1158/2159-8290.CD-22-1427
Published: 02 June 2023
View article titled, Late-Stage Metastatic Melanoma Emerges through a Diversity of Evolutionary Pathways
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Includes: Supplementary data
Journal Articles

Induction of APOBEC3 Exacerbates DNA Replication Stress and Chromosomal Instability in Early Breast and Lung Cancer Evolution

Subramanian Venkatesan, Mihaela Angelova, Clare Puttick, Haoran Zhai, Deborah R. Caswell, Wei-Ting Lu, Michelle Dietzen, Panagiotis Galanos, Konstantinos Evangelou, Roberto Bellelli, Emilia L. Lim, Thomas B.K. Watkins, Andrew Rowan, Vitor H. Teixeira, Yue Zhao, Haiquan Chen, Bryan Ngo, Lykourgos-Panagiotis Zalmas, Maise Al Bakir, Sebastijan Hobor, Eva Grönroos, Adam Pennycuick, Ersilia Nigro, Brittany B. Campbell, William L. Brown, Ayse U. Akarca, Teresa Marafioti, Mary Y. Wu, Michael Howell, Simon J. Boulton, Cosetta Bertoli, Tim R. Fenton, Robertus A.M. de Bruin, Apolinar Maya-Mendoza, Eric Santoni-Rugiu, Robert E. Hynds, Vassilis G. Gorgoulis, Mariam Jamal-Hanjani, Nicholas McGranahan, Reuben S. Harris, Sam M. Janes, Jirina Bartkova, Samuel F. Bakhoum, Jiri Bartek, Nnennaya Kanu, Charles Swanton
Journal: Cancer Discovery
Cancer Discov (2021) 11 (10): 2456–2473.
https://doi.org/10.1158/2159-8290.CD-20-0725
Published: 01 October 2021
View article titled, Induction of APOBEC3 Exacerbates DNA Replication Stress and Chromosomal Instability in Early Breast and Lung Cancer Evolution
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Includes: Supplementary data
Journal Articles

Tracking Cancer Evolution through the Disease Course

Chris Bailey, James R.M. Black, James L. Reading, Kevin Litchfield, Samra Turajlic, Nicholas McGranahan, Mariam Jamal-Hanjani, Charles Swanton
Journal: Cancer Discovery
Cancer Discov (2021) 11 (4): 916–932.
https://doi.org/10.1158/2159-8290.CD-20-1559
Published: 01 April 2021
View article titled, Tracking Cancer Evolution through the Disease Course
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Journal Articles

Immune Surveillance in Clinical Regression of Preinvasive Squamous Cell Lung Cancer

Adam Pennycuick, Vitor H. Teixeira, Khalid AbdulJabbar, Shan E. Ahmed Raza, Tom Lund, Ayse U. Akarca, Rachel Rosenthal, Lukas Kalinke, Deepak P. Chandrasekharan, Christodoulos P. Pipinikas, Henry Lee-Six, Robert E. Hynds, Kate H.C. Gowers, Jake Y. Henry, Fraser R. Millar, Yeman B. Hagos, Celine Denais, Mary Falzon, David A. Moore, Sophia Antoniou, Pascal F. Durrenberger, Andrew J. Furness, Bernadette Carroll, Claire Marceaux, Marie-Liesse Asselin-Labat, William Larson, Courtney Betts, Lisa M. Coussens, Ricky M. Thakrar, Jeremy George, Charles Swanton, Christina Thirlwell, Peter J. Campbell, Teresa Marafioti, Yinyin Yuan, Sergio A. Quezada, Nicholas McGranahan, Sam M. Janes
Journal: Cancer Discovery
Cancer Discov (2020) 10 (10): 1489–1499.
https://doi.org/10.1158/2159-8290.CD-19-1366
Published: 01 October 2020
View article titled, Immune Surveillance in Clinical Regression of Preinvasive Squamous Cell Lung Cancer
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Includes: Supplementary data
Journal Articles

APC/C Dysfunction Limits Excessive Cancer Chromosomal Instability

Laurent Sansregret, James O. Patterson, Sally Dewhurst, Carlos López-García, André Koch, Nicholas McGranahan, William Chong Hang Chao, David J. Barry, Andrew Rowan, Rachael Instrell, Stuart Horswell, Michael Way, Michael Howell, Martin R. Singleton, René H. Medema, Paul Nurse, Mark Petronczki, Charles Swanton
Journal: Cancer Discovery
Cancer Discov (2017) 7 (2): 218–233.
https://doi.org/10.1158/2159-8290.CD-16-0645
Published: 05 February 2017
View article titled, APC/C Dysfunction Limits Excessive Cancer Chromosomal Instability
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Includes: Supplementary data
Journal Articles

Tracking the Genomic Evolution of Esophageal Adenocarcinoma through Neoadjuvant Chemotherapy

Nirupa Murugaesu, Gareth A. Wilson, Nicolai J. Birkbak, Thomas B.K. Watkins, Nicholas McGranahan, Sacheen Kumar, Nima Abbassi-Ghadi, Max Salm, Richard Mitter, Stuart Horswell, Andrew Rowan, Benjamin Phillimore, Jennifer Biggs, Sharmin Begum, Nik Matthews, Daniel Hochhauser, George B. Hanna, Charles Swanton
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2015) 5 (8): 821–831.
https://doi.org/10.1158/2159-8290.CD-15-0412
Published: 03 August 2015
View article titled, Tracking the Genomic Evolution of Esophageal Adenocarcinoma through Neoadjuvant Chemotherapy
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Includes: Supplementary data
Journal Articles

APOBEC Enzymes: Mutagenic Fuel for Cancer Evolution and Heterogeneity

Charles Swanton, Nicholas McGranahan, Gabriel J. Starrett, Reuben S. Harris
Journal: Cancer Discovery
Cancer Discov (2015) 5 (7): 704–712.
https://doi.org/10.1158/2159-8290.CD-15-0344
Published: 06 July 2015
View article titled, APOBEC Enzymes: Mutagenic Fuel for Cancer Evolution and Heterogeneity
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Journal Articles

Tolerance of Whole-Genome Doubling Propagates Chromosomal Instability and Accelerates Cancer Genome Evolution

Sally M. Dewhurst, Nicholas McGranahan, Rebecca A. Burrell, Andrew J. Rowan, Eva Grönroos, David Endesfelder, Tejal Joshi, Dmitri Mouradov, Peter Gibbs, Robyn L. Ward, Nicholas J. Hawkins, Zoltan Szallasi, Oliver M. Sieber, Charles Swanton
Journal: Cancer Discovery
Cancer Discov (2014) 4 (2): 175–185.
https://doi.org/10.1158/2159-8290.CD-13-0285
Published: 04 February 2014
View article titled, Tolerance of Whole-Genome Doubling Propagates Chromosomal Instability and Accelerates Cancer Genome Evolution
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Includes: Multimedia, Supplementary data