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Neal Rosen
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Journal Articles

Molecular Characterization of Acquired Resistance to KRASG12C–EGFR Inhibition in Colorectal Cancer

Rona Yaeger, Riccardo Mezzadra, Jenna Sinopoli, Yu Bian, Michelangelo Marasco, Esther Kaplun, Yijun Gao, HuiYong Zhao, Arnaud Da Cruz Paula, Yingjie Zhu, Almudena Chaves Perez, Kalyani Chadalavada, Edison Tse, Sudhir Chowdhry, Sydney Bowker, Qing Chang, Besnik Qeriqi, Britta Weigelt, Gouri J. Nanjangud, Michael F. Berger, Hirak Der-Torossian, Kenna Anderes, Nicholas D. Socci, Jinru Shia, Gregory J. Riely, Yonina R. Murciano-Goroff, Bob T. Li, James G. Christensen, Jorge S. Reis-Filho, David B. Solit, Elisa de Stanchina, Scott W. Lowe, Neal Rosen, Sandra Misale
Journal: Cancer Discovery
Cancer Discov (2023) 13 (1): 41–55.
https://doi.org/10.1158/2159-8290.CD-22-0405
Published: 09 January 2023
View article titled, Molecular Characterization of Acquired Resistance to KRAS<sup>G12C</sup>–EGFR Inhibition in Colorectal Cancer
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Includes: Supplementary data
Journal Articles

Impaired Proteolysis of Noncanonical RAS Proteins Drives Clonal Hematopoietic Transformation

Sisi Chen, Rahul S. Vedula, Antonio Cuevas-Navarro, Bin Lu, Simon J. Hogg, Eric Wang, Salima Benbarche, Katherine Knorr, Won Jun Kim, Robert F. Stanley, Hana Cho, Caroline Erickson, Michael Singer, Dan Cui, Steven Tittley, Benjamin H. Durham, Tatiana S. Pavletich, Elise Fiala, Michael F. Walsh, Daichi Inoue, Sebastien Monette, Justin Taylor, Neal Rosen, Frank McCormick, R. Coleman Lindsley, Pau Castel, Omar Abdel-Wahab
Journal: Cancer Discovery
Cancer Discov (2022) 12 (10): 2434–2453.
https://doi.org/10.1158/2159-8290.CD-21-1631
Published: 05 October 2022
View article titled, Impaired Proteolysis of Noncanonical RAS Proteins Drives Clonal Hematopoietic Transformation
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Includes: Supplementary data
Journal Articles

INK4 Tumor Suppressor Proteins Mediate Resistance to CDK4/6 Kinase Inhibitors

Qing Li, Baishan Jiang, Jiaye Guo, Hong Shao, Isabella S. Del Priore, Qing Chang, Rei Kudo, Zhiqiang Li, Pedram Razavi, Bo Liu, Andrew S. Boghossian, Matthew G. Rees, Melissa M. Ronan, Jennifer A. Roth, Katherine A. Donovan, Marta Palafox, Jorge S. Reis-Filho, Elisa de Stanchina, Eric S. Fischer, Neal Rosen, Violeta Serra, Andrew Koff, John D. Chodera, Nathanael S. Gray, Sarat Chandarlapaty
Journal: Cancer Discovery
Cancer Discov (2022) 12 (2): 356–371.
https://doi.org/10.1158/2159-8290.CD-20-1726
Published: 01 February 2022
View article titled, INK4 Tumor Suppressor Proteins Mediate Resistance to CDK4/6 Kinase Inhibitors
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Includes: Supplementary data
Journal Articles

EGFR Blockade Reverts Resistance to KRASG12C Inhibition in Colorectal Cancer

Vito Amodio, Rona Yaeger, Pamela Arcella, Carlotta Cancelliere, Simona Lamba, Annalisa Lorenzato, Sabrina Arena, Monica Montone, Benedetta Mussolin, Yu Bian, Adele Whaley, Marika Pinnelli, Yonina R. Murciano-Goroff, Efsevia Vakiani, Nicola Valeri, Wei-Li Liao, Anuja Bhalkikar, Sheeno Thyparambil, Hui-Yong Zhao, Elisa de Stanchina, Silvia Marsoni, Salvatore Siena, Andrea Bertotti, Livio Trusolino, Bob T. Li, Neal Rosen, Federica Di Nicolantonio, Alberto Bardelli, Sandra Misale
Journal: Cancer Discovery
Cancer Discov (2020) 10 (8): 1129–1139.
https://doi.org/10.1158/2159-8290.CD-20-0187
Published: 03 August 2020
View article titled, EGFR Blockade Reverts Resistance to KRAS<sup>G12C</sup> Inhibition in Colorectal Cancer
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Includes: Supplementary data
Journal Articles

HER2-Mediated Internalization of Cytotoxic Agents in ERBB2 Amplified or Mutant Lung Cancers

Bob T. Li, Flavia Michelini, Sandra Misale, Emiliano Cocco, Laura Baldino, Yanyan Cai, Sophie Shifman, Hai-Yan Tu, Mackenzie L. Myers, Chongrui Xu, Marissa Mattar, Inna Khodos, Megan Little, Besnik Qeriqi, Gregory Weitsman, Clare J. Wilhem, Alshad S. Lalani, Irmina Diala, Rachel A. Freedman, Nancy U. Lin, David B. Solit, Michael F. Berger, Paul R. Barber, Tony Ng, Michael Offin, James M. Isbell, David R. Jones, Helena A. Yu, Sheeno Thyparambil, Wei-Li Liao, Anuja Bhalkikar, Fabiola Cecchi, David M. Hyman, Jason S. Lewis, Darren J. Buonocore, Alan L. Ho, Vicky Makker, Jorge S. Reis-Filho, Pedram Razavi, Maria E. Arcila, Mark G. Kris, John T. Poirier, Ronglai Shen, Junji Tsurutani, Gary A. Ulaner, Elisa de Stanchina, Neal Rosen, Charles M. Rudin, Maurizio Scaltriti
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2020) 10 (5): 674–687.
https://doi.org/10.1158/2159-8290.CD-20-0215
Published: 01 May 2020
View article titled, HER2-Mediated Internalization of Cytotoxic Agents in <em>ERBB2</em> Amplified or Mutant Lung Cancers
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Includes: Supplementary data
Journal Articles

V211D Mutation in MEK1 Causes Resistance to MEK Inhibitors in Colon Cancer

Yijun Gao, Ann Maria, Na Na, Arnaud da Cruz Paula, Alexander N. Gorelick, Jaclyn F. Hechtman, Julianne Carson, Robert A. Lefkowitz, Britta Weigelt, Barry S. Taylor, HuiYong Zhao, Jorge S. Reis-Filho, Elisa de Stanchina, Neal Rosen, Zhan Yao, Rona Yaeger
Journal: Cancer Discovery
Cancer Discov (2019) 9 (9): 1182–1191.
https://doi.org/10.1158/2159-8290.CD-19-0356
Published: 03 September 2019
View article titled, V211D Mutation in MEK1 Causes Resistance to MEK Inhibitors in Colon Cancer
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Includes: Supplementary data
Journal Articles

A Secondary Mutation in BRAF Confers Resistance to RAF Inhibition in a BRAFV600E-Mutant Brain Tumor

Jiawan Wang, Zhan Yao, Philip Jonsson, Amy N. Allen, Alice Can Ran Qin, Sharmeen Uddin, Ira J. Dunkel, Mary Petriccione, Katia Manova, Sofia Haque, Marc K. Rosenblum, David J. Pisapia, Neal Rosen, Barry S. Taylor, Christine A. Pratilas
Journal: Cancer Discovery
Cancer Discov (2018) 8 (9): 1130–1141.
https://doi.org/10.1158/2159-8290.CD-17-1263
Published: 04 September 2018
View article titled, A Secondary Mutation in <em>BRAF</em> Confers Resistance to RAF Inhibition in a <em>BRAF</em><sup>V600E</sup>-Mutant Brain Tumor
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Includes: Supplementary data
Journal Articles

Allele-Specific Mechanisms of Activation of MEK1 Mutants Determine Their Properties

Yijun Gao, Matthew T. Chang, Daniel McKay, Na Na, Bing Zhou, Rona Yaeger, Neilawattie M. Torres, Keven Muniz, Matthias Drosten, Mariano Barbacid, Giordano Caponigro, Darrin Stuart, Henrik Moebitz, David B. Solit, Omar Abdel-Wahab, Barry S. Taylor, Zhan Yao, Neal Rosen
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2018) 8 (5): 648–661.
https://doi.org/10.1158/2159-8290.CD-17-1452
Published: 30 April 2018
View article titled, Allele-Specific Mechanisms of Activation of MEK1 Mutants Determine Their Properties
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Includes: Supplementary data
Journal Articles

Accelerating Discovery of Functional Mutant Alleles in Cancer

Matthew T. Chang, Tripti Shrestha Bhattarai, Alison M. Schram, Craig M. Bielski, Mark T.A. Donoghue, Philip Jonsson, Debyani Chakravarty, Sarah Phillips, Cyriac Kandoth, Alexander Penson, Alexander Gorelick, Tambudzai Shamu, Swati Patel, Christopher Harris, JianJiong Gao, Selcuk Onur Sumer, Ritika Kundra, Pedram Razavi, Bob T. Li, Dalicia N. Reales, Nicholas D. Socci, Gowtham Jayakumaran, Ahmet Zehir, Ryma Benayed, Maria E. Arcila, Sarat Chandarlapaty, Marc Ladanyi, Nikolaus Schultz, José Baselga, Michael F. Berger, Neal Rosen, David B. Solit, David M. Hyman, Barry S. Taylor
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2018) 8 (2): 174–183.
https://doi.org/10.1158/2159-8290.CD-17-0321
Published: 04 February 2018
View article titled, Accelerating Discovery of Functional Mutant Alleles in Cancer
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Includes: Supplementary data
Journal Articles

Genetic Predictors of Response to Systemic Therapy in Esophagogastric Cancer

Yelena Y. Janjigian, Francisco Sanchez-Vega, Philip Jonsson, Walid K. Chatila, Jaclyn F. Hechtman, Geoffrey Y. Ku, Jamie C. Riches, Yaelle Tuvy, Ritika Kundra, Nancy Bouvier, Efsevia Vakiani, Jianjiong Gao, Zachary J. Heins, Benjamin E. Gross, David P. Kelsen, Liying Zhang, Vivian E. Strong, Mark Schattner, Hans Gerdes, Daniel G. Coit, Manjit Bains, Zsofia K. Stadler, Valerie W. Rusch, David R. Jones, Daniela Molena, Jinru Shia, Mark E. Robson, Marinela Capanu, Sumit Middha, Ahmet Zehir, David M. Hyman, Maurizio Scaltriti, Marc Ladanyi, Neal Rosen, David H. Ilson, Michael F. Berger, Laura Tang, Barry S. Taylor, David B. Solit, Nikolaus Schultz
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2018) 8 (1): 49–58.
https://doi.org/10.1158/2159-8290.CD-17-0787
Published: 07 January 2018
View article titled, Genetic Predictors of Response to Systemic Therapy in Esophagogastric Cancer
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Includes: Supplementary data
Journal Articles

Diverse and Targetable Kinase Alterations Drive Histiocytic Neoplasms

Eli L. Diamond, Benjamin H. Durham, Julien Haroche, Zhan Yao, Jing Ma, Sameer A. Parikh, Zhaoming Wang, John Choi, Eunhee Kim, Fleur Cohen-Aubart, Stanley Chun-Wei Lee, Yijun Gao, Jean-Baptiste Micol, Patrick Campbell, Michael P. Walsh, Brooke Sylvester, Igor Dolgalev, Olga Aminova, Adriana Heguy, Paul Zappile, Joy Nakitandwe, Chezi Ganzel, James D. Dalton, David W. Ellison, Juvianee Estrada-Veras, Mario Lacouture, William A. Gahl, Philip J. Stephens, Vincent A. Miller, Jeffrey S. Ross, Siraj M. Ali, Samuel R. Briggs, Omotayo Fasan, Jared Block, Sebastien Héritier, Jean Donadieu, David B. Solit, David M. Hyman, José Baselga, Filip Janku, Barry S. Taylor, Christopher Y. Park, Zahir Amoura, Ahmet Dogan, Jean-Francois Emile, Neal Rosen, Tanja A. Gruber, Omar Abdel-Wahab
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2016) 6 (2): 154–165.
https://doi.org/10.1158/2159-8290.CD-15-0913
Published: 04 February 2016
View article titled, Diverse and Targetable Kinase Alterations Drive Histiocytic Neoplasms
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Includes: Supplementary data
Journal Articles

Combined EGFR/MEK Inhibition Prevents the Emergence of Resistance in EGFR-Mutant Lung Cancer

Erin M. Tricker, Chunxiao Xu, Sharmeen Uddin, Marzia Capelletti, Dalia Ercan, Atsuko Ogino, Christine A. Pratilas, Neal Rosen, Nathanael S. Gray, Kwok-Kin Wong, Pasi A. Jänne
Journal: Cancer Discovery
Cancer Discov (2015) 5 (9): 960–971.
https://doi.org/10.1158/2159-8290.CD-15-0063
Published: 01 September 2015
View article titled, Combined EGFR/MEK Inhibition Prevents the Emergence of Resistance in <em>EGFR</em>-Mutant Lung Cancer
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Includes: Supplementary data
Journal Articles

Prospective Blinded Study of BRAFV600E Mutation Detection in Cell-Free DNA of Patients with Systemic Histiocytic Disorders

David M. Hyman, Eli L. Diamond, Cecile Rose T. Vibat, Latifa Hassaine, Jason C. Poole, Minal Patel, Veronica R. Holley, Goran Cabrilo, Timothy T. Lu, Maria E. Arcila, Young Rock Chung, Raajit Rampal, Mario E. Lacouture, Neal Rosen, Funda Meric-Bernstam, José Baselga, Razelle Kurzrock, Mark G. Erlander, Filip Janku, Omar Abdel-Wahab
Journal: Cancer Discovery
Cancer Discov (2015) 5 (1): 64–71.
https://doi.org/10.1158/2159-8290.CD-14-0742
Published: 11 January 2015
View article titled, Prospective Blinded Study of <em>BRAF</em><sup>V600E</sup> Mutation Detection in Cell-Free DNA of Patients with Systemic Histiocytic Disorders
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Includes: Supplementary data
Journal Articles

Efficacy of Intermittent Combined RAF and MEK Inhibition in a Patient with Concurrent BRAF- and NRAS-Mutant Malignancies

Omar Abdel-Wahab, Virginia M. Klimek, Alisa A. Gaskell, Agnes Viale, Donavan Cheng, Eunhee Kim, Raajit Rampal, Mark Bluth, James J. Harding, Margaret K. Callahan, Taha Merghoub, Michael F. Berger, David B. Solit, Neal Rosen, Ross L. Levine, Paul B. Chapman
Journal: Cancer Discovery
Cancer Discov (2014) 4 (5): 538–545.
https://doi.org/10.1158/2159-8290.CD-13-1038
Published: 01 May 2014
View article titled, Efficacy of Intermittent Combined RAF and MEK Inhibition in a Patient with Concurrent BRAF- and NRAS-Mutant Malignancies
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Includes: Supplementary data
Journal Articles

Rapid Induction of Apoptosis by PI3K Inhibitors Is Dependent upon Their Transient Inhibition of RAS–ERK Signaling

Marie Will, Alice Can Ran Qin, Weiyi Toy, Zhan Yao, Vanessa Rodrik-Outmezguine, Claudia Schneider, Xiaodong Huang, Prashant Monian, Xuejun Jiang, Elisa de Stanchina, José Baselga, Ningshu Liu, Sarat Chandarlapaty, Neal Rosen
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2014) 4 (3): 334–347.
https://doi.org/10.1158/2159-8290.CD-13-0611
Published: 03 March 2014
View article titled, Rapid Induction of Apoptosis by PI3K Inhibitors Is Dependent upon Their Transient Inhibition of RAS–ERK Signaling
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Includes: Supplementary data
Journal Articles

Towards a Unified Model of RAF Inhibitor Resistance

David B. Solit, Neal Rosen
Journal: Cancer Discovery
Cancer Discov (2014) 4 (1): 27–30.
https://doi.org/10.1158/2159-8290.CD-13-0961
Published: 07 January 2014
View article titled, Towards a Unified Model of RAF Inhibitor Resistance
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Journal Articles

ERK Pathway Inhibitors: How Low Should We Go?

Moriah H. Nissan, Neal Rosen, David B. Solit
Journal: Cancer Discovery
Cancer Discov (2013) 3 (7): 719–721.
https://doi.org/10.1158/2159-8290.CD-13-0245
Published: 10 July 2013
View article titled, ERK Pathway Inhibitors: How Low Should We Go?
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Journal Articles

Relief of Feedback Inhibition of HER3 Transcription by RAF and MEK Inhibitors Attenuates Their Antitumor Effects in BRAF-Mutant Thyroid Carcinomas

Cristina Montero-Conde, Sergio Ruiz-Llorente, Jose M. Dominguez, Jeffrey A. Knauf, Agnes Viale, Eric J. Sherman, Mabel Ryder, Ronald A. Ghossein, Neal Rosen, James A. Fagin
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2013) 3 (5): 520–533.
https://doi.org/10.1158/2159-8290.CD-12-0531
Published: 08 May 2013
View article titled, Relief of Feedback Inhibition of <em>HER3</em> Transcription by RAF and MEK Inhibitors Attenuates Their Antitumor Effects in <em>BRAF</em>-Mutant Thyroid Carcinomas
Open the PDF for Relief of Feedback Inhibition of <em>HER3</em> Transcription by RAF and MEK Inhibitors Attenuates Their Antitumor Effects in <em>BRAF</em>-Mutant Thyroid Carcinomas in another window
Includes: Supplementary data
Journal Articles

Reactivation of ERK Signaling Causes Resistance to EGFR Kinase Inhibitors

Dalia Ercan, Chunxiao Xu, Masahiko Yanagita, Calixte S. Monast, Christine A. Pratilas, Joan Montero, Mohit Butaney, Takeshi Shimamura, Lynette Sholl, Elena V. Ivanova, Madhavi Tadi, Andrew Rogers, Claire Repellin, Marzia Capelletti, Ophélia Maertens, Eva M. Goetz, Anthony Letai, Levi A. Garraway, Matthew J. Lazzara, Neal Rosen, Nathanael S. Gray, Kwok-Kin Wong, Pasi A. Jänne
Journal: Cancer Discovery
Cancer Discov (2012) 2 (10): 934–947.
https://doi.org/10.1158/2159-8290.CD-12-0103
Published: 14 October 2012
View article titled, Reactivation of ERK Signaling Causes Resistance to EGFR Kinase Inhibitors
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Includes: Supplementary data
Journal Articles

BRAFL597 Mutations in Melanoma Are Associated with Sensitivity to MEK Inhibitors

Kimberly Brown Dahlman, Junfeng Xia, Katherine Hutchinson, Charles Ng, Donald Hucks, Peilin Jia, Mohammad Atefi, Zengliu Su, Suzanne Branch, Pamela L. Lyle, Donna J. Hicks, Viviana Bozon, John A. Glaspy, Neal Rosen, David B. Solit, James L. Netterville, Cindy L. Vnencak-Jones, Jeffrey A. Sosman, Antoni Ribas, Zhongming Zhao, William Pao
Journal: Cancer Discovery
Cancer Discov (2012) 2 (9): 791–797.
https://doi.org/10.1158/2159-8290.CD-12-0097
Published: 10 September 2012
View article titled, <em>BRAF</em><sup>L597</sup> Mutations in Melanoma Are Associated with Sensitivity to MEK Inhibitors
Open the PDF for <em>BRAF</em><sup>L597</sup> Mutations in Melanoma Are Associated with Sensitivity to MEK Inhibitors in another window
Includes: Supplementary data