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Nathanael S. Gray
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Journal Articles

Unleashing Cell-Intrinsic Inflammation as a Strategy to Kill AML Blasts

Jana M. Ellegast, Gabriela Alexe, Amanda Hamze, Shan Lin, Hannah J. Uckelmann, Philipp J. Rauch, Maxim Pimkin, Linda S. Ross, Neekesh V. Dharia, Amanda L. Robichaud, Amy Saur Conway, Delan Khalid, Jennifer A. Perry, Mark Wunderlich, Lina Benajiba, Yana Pikman, Behnam Nabet, Nathanael S. Gray, Stuart H. Orkin, Kimberly Stegmaier
Journal: Cancer Discovery
Cancer Discov (2022) 12 (7): 1760–1781.
https://doi.org/10.1158/2159-8290.CD-21-0956
Published: 06 July 2022
View article titled, Unleashing Cell-Intrinsic Inflammation as a Strategy to Kill AML Blasts
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Includes: Supplementary data
Journal Articles

INK4 Tumor Suppressor Proteins Mediate Resistance to CDK4/6 Kinase Inhibitors

Qing Li, Baishan Jiang, Jiaye Guo, Hong Shao, Isabella S. Del Priore, Qing Chang, Rei Kudo, Zhiqiang Li, Pedram Razavi, Bo Liu, Andrew S. Boghossian, Matthew G. Rees, Melissa M. Ronan, Jennifer A. Roth, Katherine A. Donovan, Marta Palafox, Jorge S. Reis-Filho, Elisa de Stanchina, Eric S. Fischer, Neal Rosen, Violeta Serra, Andrew Koff, John D. Chodera, Nathanael S. Gray, Sarat Chandarlapaty
Journal: Cancer Discovery
Cancer Discov (2022) 12 (2): 356–371.
https://doi.org/10.1158/2159-8290.CD-20-1726
Published: 01 February 2022
View article titled, INK4 Tumor Suppressor Proteins Mediate Resistance to CDK4/6 Kinase Inhibitors
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Includes: Supplementary data
Journal Articles

Inhibition of CDK4/6 Promotes CD8 T-cell Memory Formation

Max Heckler, Lestat R. Ali, Eleanor Clancy-Thompson, Li Qiang, Katherine S. Ventre, Patrick Lenehan, Kevin Roehle, Adrienne Luoma, Kelly Boelaars, Vera Peters, Julia McCreary, Tamara Boschert, Eric S. Wang, Shengbao Suo, Francesco Marangoni, Thorsten R. Mempel, Henry W. Long, Kai W. Wucherpfennig, Michael Dougan, Nathanael S. Gray, Guo-Cheng Yuan, Shom Goel, Sara M. Tolaney, Stephanie K. Dougan
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2021) 11 (10): 2564–2581.
https://doi.org/10.1158/2159-8290.CD-20-1540
Published: 01 October 2021
View article titled, Inhibition of CDK4/6 Promotes CD8 T-cell Memory Formation
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Includes: Supplementary data
Journal Articles

Single and Dual Targeting of Mutant EGFR with an Allosteric Inhibitor

Ciric To, Jaebong Jang, Ting Chen, Eunyoung Park, Mierzhati Mushajiang, Dries J.H. De Clercq, Man Xu, Stephen Wang, Michael D. Cameron, David E. Heppner, Bo Hee Shin, Thomas W. Gero, Annan Yang, Suzanne E. Dahlberg, Kwok-Kin Wong, Michael J. Eck, Nathanael S. Gray, Pasi A. Jänne
Journal: Cancer Discovery
Cancer Discov (2019) 9 (7): 926–943.
https://doi.org/10.1158/2159-8290.CD-18-0903
Published: 01 July 2019
View article titled, Single and Dual Targeting of Mutant EGFR with an Allosteric Inhibitor
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Includes: Supplementary data
Journal Articles

CDK4/6 Inhibition Augments Antitumor Immunity by Enhancing T-cell Activation

Jiehui Deng, Eric S. Wang, Russell W. Jenkins, Shuai Li, Ruben Dries, Kathleen Yates, Sandeep Chhabra, Wei Huang, Hongye Liu, Amir R. Aref, Elena Ivanova, Cloud P. Paweletz, Michaela Bowden, Chensheng W. Zhou, Grit S. Herter-Sprie, Jessica A. Sorrentino, John E. Bisi, Patrick H. Lizotte, Ashley A. Merlino, Max M. Quinn, Lauren E. Bufe, Annan Yang, Yanxi Zhang, Hua Zhang, Peng Gao, Ting Chen, Megan E. Cavanaugh, Amanda J. Rode, Eric Haines, Patrick J. Roberts, Jay C. Strum, William G. Richards, Jochen H. Lorch, Sareh Parangi, Viswanath Gunda, Genevieve M. Boland, Raphael Bueno, Sangeetha Palakurthi, Gordon J. Freeman, Jerome Ritz, W. Nicholas Haining, Norman E. Sharpless, Haribabu Arthanari, Geoffrey I. Shapiro, David A. Barbie, Nathanael S. Gray, Kwok-Kin Wong
Journal: Cancer Discovery
Cancer Discov (2018) 8 (2): 216–233.
https://doi.org/10.1158/2159-8290.CD-17-0915
Published: 04 February 2018
View article titled, CDK4/6 Inhibition Augments Antitumor Immunity by Enhancing T-cell Activation
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Includes: Supplementary data
Journal Articles

Suppression of Adaptive Responses to Targeted Cancer Therapy by Transcriptional Repression

Maria Rusan, Kapsok Li, Yvonne Li, Camilla L. Christensen, Brian J. Abraham, Nicholas Kwiatkowski, Kevin A. Buczkowski, Bruno Bockorny, Ting Chen, Shuai Li, Kevin Rhee, Haikuo Zhang, Wankun Chen, Hideki Terai, Tiffany Tavares, Alan L. Leggett, Tianxia Li, Yichen Wang, Tinghu Zhang, Tae-Jung Kim, Sook-Hee Hong, Neermala Poudel-Neupane, Michael Silkes, Tenny Mudianto, Li Tan, Takeshi Shimamura, Matthew Meyerson, Adam J. Bass, Hideo Watanabe, Nathanael S. Gray, Richard A. Young, Kwok-Kin Wong, Peter S. Hammerman
Journal: Cancer Discovery
Cancer Discov (2018) 8 (1): 59–73.
https://doi.org/10.1158/2159-8290.CD-17-0461
Published: 07 January 2018
View article titled, Suppression of Adaptive Responses to Targeted Cancer Therapy by Transcriptional Repression
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Includes: Supplementary data
Journal Articles

Progress on Covalent Inhibition of KRASG12C

Kenneth D. Westover, Pasi A. Jänne, Nathanael S. Gray
Journal: Cancer Discovery
Cancer Discov (2016) 6 (3): 233–234.
https://doi.org/10.1158/2159-8290.CD-16-0092
Published: 06 March 2016
View article titled, Progress on Covalent Inhibition of KRAS<sup>G12C</sup>
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Journal Articles

Combined EGFR/MEK Inhibition Prevents the Emergence of Resistance in EGFR-Mutant Lung Cancer

Erin M. Tricker, Chunxiao Xu, Sharmeen Uddin, Marzia Capelletti, Dalia Ercan, Atsuko Ogino, Christine A. Pratilas, Neal Rosen, Nathanael S. Gray, Kwok-Kin Wong, Pasi A. Jänne
Journal: Cancer Discovery
Cancer Discov (2015) 5 (9): 960–971.
https://doi.org/10.1158/2159-8290.CD-15-0063
Published: 01 September 2015
View article titled, Combined EGFR/MEK Inhibition Prevents the Emergence of Resistance in <em>EGFR</em>-Mutant Lung Cancer
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Includes: Supplementary data
Journal Articles

EPHA2 Is a Mediator of Vemurafenib Resistance and a Novel Therapeutic Target in Melanoma

Benchun Miao, Zhenyu Ji, Li Tan, Michael Taylor, Jianming Zhang, Hwan Geun Choi, Dennie T. Frederick, Raj Kumar, Jennifer A. Wargo, Keith T. Flaherty, Nathanael S. Gray, Hensin Tsao
Journal: Cancer Discovery
Cancer Discov (2015) 5 (3): 274–287.
https://doi.org/10.1158/2159-8290.CD-14-0295
Published: 05 March 2015
View article titled, EPHA2 Is a Mediator of Vemurafenib Resistance and a Novel Therapeutic Target in Melanoma
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Includes: Supplementary data
Journal Articles

Metabolic and Functional Genomic Studies Identify Deoxythymidylate Kinase as a Target in LKB1-Mutant Lung Cancer

Yan Liu, Kevin Marks, Glenn S. Cowley, Julian Carretero, Qingsong Liu, Thomas J.F. Nieland, Chunxiao Xu, Travis J. Cohoon, Peng Gao, Yong Zhang, Zhao Chen, Abigail B. Altabef, Jeremy H. Tchaicha, Xiaoxu Wang, Sung Choe, Edward M. Driggers, Jianming Zhang, Sean T. Bailey, Norman E. Sharpless, D. Neil Hayes, Nirali M. Patel, Pasi A. Janne, Nabeel Bardeesy, Jeffrey A. Engelman, Brendan D. Manning, Reuben J. Shaw, John M. Asara, Ralph Scully, Alec Kimmelman, Lauren A. Byers, Don L. Gibbons, Ignacio I. Wistuba, John V. Heymach, David J. Kwiatkowski, William Y. Kim, Andrew L. Kung, Nathanael S. Gray, David E. Root, Lewis C. Cantley, Kwok-Kin Wong
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2013) 3 (8): 870–879.
https://doi.org/10.1158/2159-8290.CD-13-0015
Published: 07 August 2013
View article titled, Metabolic and Functional Genomic Studies Identify Deoxythymidylate Kinase as a Target in <em>LKB1</em>-Mutant Lung Cancer
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Includes: Supplementary data
Journal Articles

TYK2–STAT1–BCL2 Pathway Dependence in T-cell Acute Lymphoblastic Leukemia

Takaomi Sanda, Jeffrey W. Tyner, Alejandro Gutierrez, Vu N. Ngo, Jason Glover, Bill H. Chang, Arla Yost, Wenxue Ma, Angela G. Fleischman, Wenjun Zhou, Yandan Yang, Maria Kleppe, Yebin Ahn, Jessica Tatarek, Michelle A. Kelliher, Donna S. Neuberg, Ross L. Levine, Richard Moriggl, Mathias Müller, Nathanael S. Gray, Catriona H.M. Jamieson, Andrew P. Weng, Louis M. Staudt, Brian J. Druker, A. Thomas Look
Journal: Cancer Discovery
Cancer Discov (2013) 3 (5): 564–577.
https://doi.org/10.1158/2159-8290.CD-12-0504
Published: 08 May 2013
View article titled, TYK2–STAT1–BCL2 Pathway Dependence in T-cell Acute Lymphoblastic Leukemia
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Includes: Supplementary data
Journal Articles

Reactivation of ERK Signaling Causes Resistance to EGFR Kinase Inhibitors

Dalia Ercan, Chunxiao Xu, Masahiko Yanagita, Calixte S. Monast, Christine A. Pratilas, Joan Montero, Mohit Butaney, Takeshi Shimamura, Lynette Sholl, Elena V. Ivanova, Madhavi Tadi, Andrew Rogers, Claire Repellin, Marzia Capelletti, Ophélia Maertens, Eva M. Goetz, Anthony Letai, Levi A. Garraway, Matthew J. Lazzara, Neal Rosen, Nathanael S. Gray, Kwok-Kin Wong, Pasi A. Jänne
Journal: Cancer Discovery
Cancer Discov (2012) 2 (10): 934–947.
https://doi.org/10.1158/2159-8290.CD-12-0103
Published: 14 October 2012
View article titled, Reactivation of ERK Signaling Causes Resistance to EGFR Kinase Inhibitors
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Includes: Supplementary data
Journal Articles

Mutations in the DDR2 Kinase Gene Identify a Novel Therapeutic Target in Squamous Cell Lung Cancer

Peter S. Hammerman, Martin L. Sos, Alex H. Ramos, Chunxiao Xu, Amit Dutt, Wenjun Zhou, Lear E. Brace, Brittany A. Woods, Wenchu Lin, Jianming Zhang, Xianming Deng, Sang Min Lim, Stefanie Heynck, Martin Peifer, Jeffrey R. Simard, Michael S. Lawrence, Robert C. Onofrio, Helga B. Salvesen, Danila Seidel, Thomas Zander, Johannes M. Heuckmann, Alex Soltermann, Holger Moch, Mirjam Koker, Frauke Leenders, Franziska Gabler, Silvia Querings, Sascha Ansén, Elisabeth Brambilla, Christian Brambilla, Philippe Lorimier, Odd Terje Brustugun, Åslaug Helland, Iver Petersen, Joachim H. Clement, Harry Groen, Wim Timens, Hannie Sietsma, Erich Stoelben, Jürgen Wolf, David G. Beer, Ming Sound Tsao, Megan Hanna, Charles Hatton, Michael J. Eck, Pasi A. Janne, Bruce E. Johnson, Wendy Winckler, Heidi Greulich, Adam J. Bass, Jeonghee Cho, Daniel Rauh, Nathanael S. Gray, Kwok-Kin Wong, Eric B. Haura, Roman K. Thomas, Matthew Meyerson
Journal: Cancer Discovery
Cancer Discov (2011) 1 (1): 78–89.
https://doi.org/10.1158/2159-8274.CD-11-0005
Published: 01 June 2011
View article titled, Mutations in the <em>DDR2</em> Kinase Gene Identify a Novel Therapeutic Target in Squamous Cell Lung Cancer
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Includes: Multimedia, Supplementary data