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Michel Sadelain
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Journal Articles

Disruption of SUV39H1-Mediated H3K9 Methylation Sustains CAR T-cell Function

Nayan Jain, Zeguo Zhao, Richard P. Koche, Chenling Antelope, Yosi Gozlan, Antonino Montalbano, David Brocks, Michael Lopez, Anton Dobrin, Yuzhe Shi, Gertrude Gunset, Theodoros Giavridis, Michel Sadelain
Journal: Cancer Discovery
Cancer Discov (2024) 14 (1): 142–157.
https://doi.org/10.1158/2159-8290.CD-22-1319
Published: 12 January 2024
View article titled, Disruption of <em>SUV39H1</em>-Mediated H3K9 Methylation Sustains CAR T-cell Function
Open the PDF for Disruption of <em>SUV39H1</em>-Mediated H3K9 Methylation Sustains CAR T-cell Function in another window
Includes: Supplementary data
Journal Articles

Programming CAR T Cell Tumor Recognition: Tuned Antigen Sensing and Logic Gating

Mohamad Hamieh, Jorge Mansilla-Soto, Isabelle Rivière, Michel Sadelain
Journal: Cancer Discovery
Cancer Discov (2023) 13 (4): 829–843.
https://doi.org/10.1158/2159-8290.CD-23-0101
Published: 03 April 2023
View article titled, Programming CAR T Cell Tumor Recognition: Tuned Antigen Sensing and Logic Gating
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Journal Articles

A Phase I Trial of Regional Mesothelin-Targeted CAR T-cell Therapy in Patients with Malignant Pleural Disease, in Combination with the Anti–PD-1 Agent Pembrolizumab

Prasad S. Adusumilli, Marjorie G. Zauderer, Isabelle Rivière, Stephen B. Solomon, Valerie W. Rusch, Roisin E. O'Cearbhaill, Amy Zhu, Waseem Cheema, Navin K. Chintala, Elizabeth Halton, John Pineda, Rocio Perez-Johnston, Kay See Tan, Bobby Daly, Jose A. Araujo Filho, Daniel Ngai, Erin McGee, Alain Vincent, Claudia Diamonte, Jennifer L. Sauter, Shanu Modi, Devanjan Sikder, Brigitte Senechal, Xiuyan Wang, William D. Travis, Mithat Gönen, Charles M. Rudin, Renier J. Brentjens, David R. Jones, Michel Sadelain
Journal: Cancer Discovery
Cancer Discov (2021) 11 (11): 2748–2763.
https://doi.org/10.1158/2159-8290.CD-21-0407
Published: 01 November 2021
View article titled, A Phase I Trial of Regional Mesothelin-Targeted CAR T-cell Therapy in Patients with Malignant Pleural Disease, in Combination with the Anti–PD-1 Agent Pembrolizumab
Open the PDF for A Phase I Trial of Regional Mesothelin-Targeted CAR T-cell Therapy in Patients with Malignant Pleural Disease, in Combination with the Anti–PD-1 Agent Pembrolizumab in another window
Includes: Supplementary data
Journal Articles

Clinical and Biological Correlates of Neurotoxicity Associated with CAR T-cell Therapy in Patients with B-cell Acute Lymphoblastic Leukemia

Bianca D. Santomasso, Jae H. Park, Darin Salloum, Isabelle Riviere, Jessica Flynn, Elena Mead, Elizabeth Halton, Xiuyan Wang, Brigitte Senechal, Terence Purdon, Justin R. Cross, Hui Liu, Behroze Vachha, Xi Chen, Lisa M. DeAngelis, Daniel Li, Yvette Bernal, Mithat Gonen, Hans-Guido Wendel, Michel Sadelain, Renier J. Brentjens
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2018) 8 (8): 958–971.
https://doi.org/10.1158/2159-8290.CD-17-1319
Published: 02 August 2018
View article titled, Clinical and Biological Correlates of Neurotoxicity Associated with CAR T-cell Therapy in Patients with B-cell Acute Lymphoblastic Leukemia
Open the PDF for Clinical and Biological Correlates of Neurotoxicity Associated with CAR T-cell Therapy in Patients with B-cell Acute Lymphoblastic Leukemia in another window
Includes: Supplementary data
Journal Articles

Mesothelin-Targeted CARs: Driving T Cells to Solid Tumors

Aurore Morello, Michel Sadelain, Prasad S. Adusumilli
Journal: Cancer Discovery
Cancer Discov (2016) 6 (2): 133–146.
https://doi.org/10.1158/2159-8290.CD-15-0583
Published: 04 February 2016
View article titled, Mesothelin-Targeted CARs: Driving T Cells to Solid Tumors
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Includes: Supplementary data
Journal Articles

The Basic Principles of Chimeric Antigen Receptor Design

Michel Sadelain, Renier Brentjens, Isabelle Rivière
Journal: Cancer Discovery
Cancer Discov (2013) 3 (4): 388–398.
https://doi.org/10.1158/2159-8290.CD-12-0548
Published: 10 April 2013
View article titled, The Basic Principles of Chimeric Antigen Receptor Design
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Includes: Supplementary data