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Michael A. Davies
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Journal Articles

Tilsotolimod with Ipilimumab Drives Tumor Responses in Anti–PD-1 Refractory Melanoma

Cara Haymaker, Daniel H. Johnson, Ravi Murthy, Salah-Eddine Bentebibel, Marc I. Uemura, Courtney W. Hudgens, Houssein Safa, Marihella James, Robert H.I. Andtbacka, Douglas B. Johnson, Montaser Shaheen, Michael A. Davies, Shah Rahimian, Srinivas K. Chunduru, Denái R. Milton, Michael T. Tetzlaff, Willem W. Overwijk, Patrick Hwu, Nashat Gabrail, Sudhir Agrawal, Gary Doolittle, Igor Puzanov, Joseph Markowitz, Chantale Bernatchez, Adi Diab
Journal: Cancer Discovery
Cancer Discov (2021) 11 (8): 1996–2013.
https://doi.org/10.1158/2159-8290.CD-20-1546
Published: 01 August 2021
View articletitled, Tilsotolimod with Ipilimumab Drives Tumor Responses in Anti–PD-1 Refractory Melanoma
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Includes: Supplementary data
Journal Articles

Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition

Bryan Ngo, Eugenie Kim, Victoria Osorio-Vasquez, Sophia Doll, Sophia Bustraan, Roger J. Liang, Alba Luengo, Shawn M. Davidson, Ahmed Ali, Gino B. Ferraro, Grant M. Fischer, Roozbeh Eskandari, Diane S. Kang, Jing Ni, Ariana Plasger, Vinagolu K. Rajasekhar, Edward R. Kastenhuber, Sarah Bacha, Roshan K. Sriram, Benjamin D. Stein, Samuel F. Bakhoum, Matija Snuderl, Paolo Cotzia, John H. Healey, Nello Mainolfi, Vipin Suri, Adam Friedman, Mark Manfredi, David M. Sabatini, Drew R. Jones, Min Yu, Jean J. Zhao, Rakesh K. Jain, Kayvan R. Keshari, Michael A. Davies, Matthew G. Vander Heiden, Eva Hernando, Matthias Mann, Lewis C. Cantley, Michael E. Pacold
Journal: Cancer Discovery
Cancer Discov (2020) 10 (9): 1352–1373.
https://doi.org/10.1158/2159-8290.CD-19-1228
Published: 01 September 2020
View articletitled, Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition
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Includes: Supplementary data
Journal Articles

Molecular Profiling Reveals Unique Immune and Metabolic Features of Melanoma Brain Metastases

Grant M. Fischer, Ali Jalali, David A. Kircher, Won-Chul Lee, Jennifer L. McQuade, Lauren E. Haydu, Aron Y. Joon, Alexandre Reuben, Mariana P. de Macedo, Fernando C. L. Carapeto, Chendong Yang, Anuj Srivastava, Chandrashekar R. Ambati, Arun Sreekumar, Courtney W. Hudgens, Barbara Knighton, Wanleng Deng, Sherise D. Ferguson, Hussein A. Tawbi, Isabella C. Glitza, Jeffrey E. Gershenwald, Y. N. Vashisht Gopal, Patrick Hwu, Jason T. Huse, Jennifer A. Wargo, P. Andrew Futreal, Nagireddy Putluri, Alexander J. Lazar, Ralph J. DeBerardinis, Joseph R. Marszalek, Jianjun Zhang, Sheri L. Holmen, Michael T. Tetzlaff, Michael A. Davies
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2019) 9 (5): 628–645.
https://doi.org/10.1158/2159-8290.CD-18-1489
Published: 01 May 2019
View articletitled, Molecular Profiling Reveals Unique Immune and Metabolic Features of Melanoma Brain Metastases
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Includes: Supplementary data
Journal Articles

Correction: In Vivo E2F Reporting Reveals Efficacious Schedules of MEK1/2–CDK4/6 Targeting and mTOR–S6 Resistance Mechanisms

Jessica L.F. Teh, Phil F. Cheng, Timothy J. Purwin, Neda Nikbakht, Prem Patel, Inna Chervoneva, Adam Ertel, Paolo M. Fortina, Ines Kleiber, Kim HooKim, Michael A. Davies, Lawrence N. Kwong, Mitch P. Levesque, Reinhard Dummer, Andrew E. Aplin
Journal: Cancer Discovery
Cancer Discov (2018) 8 (12): 1654.
https://doi.org/10.1158/2159-8290.CD-18-1291
Published: 03 December 2018
View articletitled, Correction: In Vivo E2F Reporting Reveals Efficacious Schedules of MEK1/2–CDK4/6 Targeting and mTOR–S6 Resistance Mechanisms
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Journal Articles

In Vivo E2F Reporting Reveals Efficacious Schedules of MEK1/2–CDK4/6 Targeting and mTOR–S6 Resistance Mechanisms

Jessica L.F. Teh, Phil F. Cheng, Timothy J. Purwin, Neda Nikbakht, Prem Patel, Inna Chervoneva, Adam Ertel, Paolo M. Fortina, Ines Kleiber, Kim HooKim, Michael A. Davies, Lawrence N. Kwong, Mitch P. Levesque, Reinhard Dummer, Andrew E. Aplin
Journal: Cancer Discovery
Cancer Discov (2018) 8 (5): 568–581.
https://doi.org/10.1158/2159-8290.CD-17-0699
Published: 30 April 2018
View articletitled, In Vivo E2F Reporting Reveals Efficacious Schedules of MEK1/2–CDK4/6 Targeting and mTOR–S6 Resistance Mechanisms
Open the PDF for In Vivo E2F Reporting Reveals Efficacious Schedules of MEK1/2–CDK4/6 Targeting and mTOR–S6 Resistance Mechanisms in another window
Includes: Supplementary data
Journal Articles

A Preexisting Rare PIK3CAE545K Subpopulation Confers Clinical Resistance to MEK plus CDK4/6 Inhibition in NRAS Melanoma and Is Dependent on S6K1 Signaling

Gabriele Romano, Pei-Ling Chen, Ping Song, Jennifer L. McQuade, Roger J. Liang, Mingguang Liu, Whijae Roh, Dzifa Y. Duose, Fernando C.L. Carapeto, Jun Li, Jessica L.F. Teh, Andrew E. Aplin, Merry Chen, Jianhua Zhang, Alexander J. Lazar, Michael A. Davies, P. Andrew Futreal, Rodabe N. Amaria, David Y. Zhang, Jennifer A. Wargo, Lawrence N. Kwong
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2018) 8 (5): 556–567.
https://doi.org/10.1158/2159-8290.CD-17-0745
Published: 30 April 2018
View articletitled, A Preexisting Rare PIK3CAE545K Subpopulation Confers Clinical Resistance to MEK plus CDK4/6 Inhibition in NRAS Melanoma and Is Dependent on S6K1 Signaling
Open the PDF for A Preexisting Rare PIK3CAE545K Subpopulation Confers Clinical Resistance to MEK plus CDK4/6 Inhibition in NRAS Melanoma and Is Dependent on S6K1 Signaling in another window
Includes: Supplementary data
Journal Articles

Biomarker Accessible and Chemically Addressable Mechanistic Subtypes of BRAF Melanoma

Banu Eskiocak, Elizabeth A. McMillan, Saurabh Mendiratta, Rahul K. Kollipara, Hailei Zhang, Caroline G. Humphries, Changguang Wang, Jose Garcia-Rodriguez, Ming Ding, Aubhishek Zaman, Tracy I. Rosales, Ugur Eskiocak, Michael P. Smith, Jessica Sudderth, Kakajan Komurov, Ralph J. Deberardinis, Claudia Wellbrock, Michael A. Davies, Jennifer A. Wargo, Yonghao Yu, Jef K. De Brabander, Noelle S. Williams, Lynda Chin, Helen Rizos, Georgina V. Long, Ralf Kittler, Michael A. White
Journal: Cancer Discovery
Cancer Discov (2017) 7 (8): 832–851.
https://doi.org/10.1158/2159-8290.CD-16-0955
Published: 01 August 2017
View articletitled, Biomarker Accessible and Chemically Addressable Mechanistic Subtypes of BRAF Melanoma
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Includes: Supplementary data
Journal Articles

Analysis of Immune Signatures in Longitudinal Tumor Samples Yields Insight into Biomarkers of Response and Mechanisms of Resistance to Immune Checkpoint Blockade

Pei-Ling Chen, Whijae Roh, Alexandre Reuben, Zachary A. Cooper, Christine N. Spencer, Peter A. Prieto, John P. Miller, Roland L. Bassett, Vancheswaran Gopalakrishnan, Khalida Wani, Mariana Petaccia De Macedo, Jacob L. Austin-Breneman, Hong Jiang, Qing Chang, Sangeetha M. Reddy, Wei-Shen Chen, Michael T. Tetzlaff, Russell J. Broaddus, Michael A. Davies, Jeffrey E. Gershenwald, Lauren Haydu, Alexander J. Lazar, Sapna P. Patel, Patrick Hwu, Wen-Jen Hwu, Adi Diab, Isabella C. Glitza, Scott E. Woodman, Luis M. Vence, Ignacio I. Wistuba, Rodabe N. Amaria, Lawrence N. Kwong, Victor Prieto, R. Eric Davis, Wencai Ma, Willem W. Overwijk, Arlene H. Sharpe, Jianhua Hu, P. Andrew Futreal, Jorge Blando, Padmanee Sharma, James P. Allison, Lynda Chin, Jennifer A. Wargo
Journal: Cancer Discovery
Cancer Discov (2016) 6 (8): 827–837.
https://doi.org/10.1158/2159-8290.CD-15-1545
Published: 01 August 2016
View articletitled, Analysis of Immune Signatures in Longitudinal Tumor Samples Yields Insight into Biomarkers of Response and Mechanisms of Resistance to Immune Checkpoint Blockade
Open the PDF for Analysis of Immune Signatures in Longitudinal Tumor Samples Yields Insight into Biomarkers of Response and Mechanisms of Resistance to Immune Checkpoint Blockade in another window
Includes: Supplementary data
Journal Articles

Loss of PTEN Promotes Resistance to T Cell–Mediated Immunotherapy

Weiyi Peng, Jie Qing Chen, Chengwen Liu, Shruti Malu, Caitlin Creasy, Michael T. Tetzlaff, Chunyu Xu, Jodi A. McKenzie, Chunlei Zhang, Xiaoxuan Liang, Leila J. Williams, Wanleng Deng, Guo Chen, Rina Mbofung, Alexander J. Lazar, Carlos A. Torres-Cabala, Zachary A. Cooper, Pei-Ling Chen, Trang N. Tieu, Stefani Spranger, Xiaoxing Yu, Chantale Bernatchez, Marie-Andree Forget, Cara Haymaker, Rodabe Amaria, Jennifer L. McQuade, Isabella C. Glitza, Tina Cascone, Haiyan S. Li, Lawrence N. Kwong, Timothy P. Heffernan, Jianhua Hu, Roland L. Bassett, Jr, Marcus W. Bosenberg, Scott E. Woodman, Willem W. Overwijk, Gregory Lizée, Jason Roszik, Thomas F. Gajewski, Jennifer A. Wargo, Jeffrey E. Gershenwald, Laszlo Radvanyi, Michael A. Davies, Patrick Hwu
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2016) 6 (2): 202–216.
https://doi.org/10.1158/2159-8290.CD-15-0283
Published: 04 February 2016
View articletitled, Loss of PTEN Promotes Resistance to T Cell–Mediated Immunotherapy
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Includes: Supplementary data
Journal Articles

Finding the Right Balance of BRAF Inhibition in Melanoma

Michael A. Davies
Journal: Cancer Discovery
Cancer Discov (2014) 4 (5): 510–512.
https://doi.org/10.1158/2159-8290.CD-14-0307
Published: 01 May 2014
View articletitled, Finding the Right Balance of BRAF Inhibition in Melanoma
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