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Meenhard Herlyn
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Journal Articles

Targeting UGCG Overcomes Resistance to Lysosomal Autophagy Inhibition

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Vaibhav Jain, Sandra L. Harper, Amanda M. Versace, Dylan Fingerman, Gregory Schuyler Brown, Monika Bhardwaj, Mary Ann S. Crissey, Aaron R. Goldman, Gordon Ruthel, Qin Liu, Aleksandra Zivkovic, Holgar Stark, Meenhard Herlyn, Phyllis A. Gimotty, David W. Speicher, Ravi K. Amaravadi
Journal: Cancer Discovery
Cancer Discov (2023) 13 (2): 454–473.
https://doi.org/10.1158/2159-8290.CD-22-0535
Published: 06 February 2023
View articletitled, Targeting UGCG Overcomes Resistance to Lysosomal Autophagy Inhibition
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Includes: Supplementary data
Journal Articles

Exploiting Allosteric Properties of RAF and MEK Inhibitors to Target Therapy-Resistant Tumors Driven by Oncogenic BRAF Signaling

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Christos Adamopoulos, Tamer A. Ahmed, Maxwell R. Tucker, Peter M.U. Ung, Min Xiao, Zoi Karoulia, Angelo Amabile, Xuewei Wu, Stuart A. Aaronson, Celina Ang, Vito W. Rebecca, Brian D. Brown, Avner Schlessinger, Meenhard Herlyn, Qi Wang, David E. Shaw, Poulikos I. Poulikakos
Journal: Cancer Discovery
Cancer Discov (2021) 11 (7): 1716–1735.
https://doi.org/10.1158/2159-8290.CD-20-1351
Published: 01 July 2021
View articletitled, Exploiting Allosteric Properties of RAF and MEK Inhibitors to Target Therapy-Resistant Tumors Driven by Oncogenic BRAF Signaling
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Includes: Multimedia, Supplementary data
Journal Articles

Changes in Aged Fibroblast Lipid Metabolism Induce Age-Dependent Melanoma Cell Resistance to Targeted Therapy via the Fatty Acid Transporter FATP2

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Gretchen M. Alicea, Vito W. Rebecca, Aaron R. Goldman, Mitchell E. Fane, Stephen M. Douglass, Reeti Behera, Marie R. Webster, Curtis H. Kugel, III, Brett L. Ecker, M. Cecilia Caino, Andrew V. Kossenkov, Hsin-Yao Tang, Dennie T. Frederick, Keith T. Flaherty, Xiaowei Xu, Qin Liu, Dmitry I. Gabrilovich, Meenhard Herlyn, Ian A. Blair, Zachary T. Schug, David W. Speicher, Ashani T. Weeraratna
Journal: Cancer Discovery
Cancer Discov (2020) 10 (9): 1282–1295.
https://doi.org/10.1158/2159-8290.CD-20-0329
Published: 01 September 2020
View articletitled, Changes in Aged Fibroblast Lipid Metabolism Induce Age-Dependent Melanoma Cell Resistance to Targeted Therapy via the Fatty Acid Transporter FATP2
Open the PDF for Changes in Aged Fibroblast Lipid Metabolism Induce Age-Dependent Melanoma Cell Resistance to Targeted Therapy via the Fatty Acid Transporter FATP2 in another window
Includes: Multimedia, Supplementary data
Journal Articles

Polyunsaturated Fatty Acids from Astrocytes Activate PPARγ Signaling in Cancer Cells to Promote Brain Metastasis

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Yongkang Zou, Andrea Watters, Nan Cheng, Caroline E. Perry, Ke Xu, Gretchen M. Alicea, Joshua L.D. Parris, Ezra Baraban, Pulak Ray, Anupma Nayak, Xiaowei Xu, Meenhard Herlyn, Maureen E. Murphy, Ashani T. Weeraratna, Zachary T. Schug, Qing Chen
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2019) 9 (12): 1720–1735.
https://doi.org/10.1158/2159-8290.CD-19-0270
Published: 02 December 2019
View articletitled, Polyunsaturated Fatty Acids from Astrocytes Activate PPARγ Signaling in Cancer Cells to Promote Brain Metastasis
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Includes: Supplementary data
Journal Articles

ER Translocation of the MAPK Pathway Drives Therapy Resistance in BRAF-Mutant Melanoma

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Rani Ojha, Nektaria M. Leli, Angelique Onorati, Shengfu Piao, Ioannis I. Verginadis, Feven Tameire, Vito W. Rebecca, Cynthia I. Chude, Sengottuvelan Murugan, Colin Fennelly, Estela Noguera-Ortega, Charleen T. Chu, Shujing Liu, Xiaowei Xu, Clemens Krepler, Min Xiao, Wei Xu, Zhi Wei, Dennie T. Frederick, Genevieve Boland, Tara C. Mitchell, Giorgos C. Karakousis, Lynn M. Schuchter, Keith T. Flaherty, Gao Zhang, Meenhard Herlyn, Constantinos Koumenis, Ravi K. Amaravadi
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2019) 9 (3): 396–415.
https://doi.org/10.1158/2159-8290.CD-18-0348
Published: 01 March 2019
View articletitled, ER Translocation of the MAPK Pathway Drives Therapy Resistance in BRAF-Mutant Melanoma
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Includes: Multimedia, Supplementary data
Journal Articles

PPT1 Promotes Tumor Growth and Is the Molecular Target of Chloroquine Derivatives in Cancer

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Vito W. Rebecca, Michael C. Nicastri, Colin Fennelly, Cynthia I. Chude, Julie S. Barber-Rotenberg, Amruta Ronghe, Quentin McAfee, Noel P. McLaughlin, Gao Zhang, Aaron R. Goldman, Rani Ojha, Shengfu Piao, Estela Noguera-Ortega, Alessandra Martorella, Gretchen M. Alicea, Jennifer J. Lee, Lynn M. Schuchter, Xiaowei Xu, Meenhard Herlyn, Ronen Marmorstein, Phyllis A. Gimotty, David W. Speicher, Jeffrey D. Winkler, Ravi K. Amaravadi
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2019) 9 (2): 220–229.
https://doi.org/10.1158/2159-8290.CD-18-0706
Published: 08 February 2019
View articletitled, PPT1 Promotes Tumor Growth and Is the Molecular Target of Chloroquine Derivatives in Cancer
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Includes: Supplementary data
Journal Articles

Remodeling of the Collagen Matrix in Aging Skin Promotes Melanoma Metastasis and Affects Immune Cell Motility

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Amanpreet Kaur, Brett L. Ecker, Stephen M. Douglass, Curtis H. Kugel, III, Marie R. Webster, Filipe V. Almeida, Rajasekharan Somasundaram, James Hayden, Ehsan Ban, Hossein Ahmadzadeh, Janusz Franco-Barraza, Neelima Shah, Ian A. Mellis, Frederick Keeney, Andrew Kossenkov, Hsin-Yao Tang, Xiangfan Yin, Qin Liu, Xiaowei Xu, Mitchell Fane, Patricia Brafford, Meenhard Herlyn, David W. Speicher, Jennifer A. Wargo, Michael T. Tetzlaff, Lauren E. Haydu, Arjun Raj, Vivek Shenoy, Edna Cukierman, Ashani T. Weeraratna
Journal: Cancer Discovery
Cancer Discov (2019) 9 (1): 64–81.
https://doi.org/10.1158/2159-8290.CD-18-0193
Published: 09 January 2019
View articletitled, Remodeling of the Collagen Matrix in Aging Skin Promotes Melanoma Metastasis and Affects Immune Cell Motility
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Includes: Multimedia, Supplementary data
Journal Articles

Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids

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Russell W. Jenkins, Amir R. Aref, Patrick H. Lizotte, Elena Ivanova, Susanna Stinson, Chensheng W. Zhou, Michaela Bowden, Jiehui Deng, Hongye Liu, Diana Miao, Meng Xiao He, William Walker, Gao Zhang, Tian Tian, Chaoran Cheng, Zhi Wei, Sangeetha Palakurthi, Mark Bittinger, Hans Vitzthum, Jong Wook Kim, Ashley Merlino, Max Quinn, Chandrasekar Venkataramani, Joshua A. Kaplan, Andrew Portell, Prafulla C. Gokhale, Bart Phillips, Alicia Smart, Asaf Rotem, Robert E. Jones, Lauren Keogh, Maria Anguiano, Lance Stapleton, Zhiheng Jia, Michal Barzily-Rokni, Israel Cañadas, Tran C. Thai, Marc R. Hammond, Raven Vlahos, Eric S. Wang, Hua Zhang, Shuai Li, Glenn J. Hanna, Wei Huang, Mai P. Hoang, Adriano Piris, Jean-Pierre Eliane, Anat O. Stemmer-Rachamimov, Lisa Cameron, Mei-Ju Su, Parin Shah, Benjamin Izar, Manisha Thakuria, Nicole R. LeBoeuf, Guilherme Rabinowits, Viswanath Gunda, Sareh Parangi, James M. Cleary, Brian C. Miller, Shunsuke Kitajima, Rohit Thummalapalli, Benchun Miao, Thanh U. Barbie, Vivek Sivathanu, Joshua Wong, William G. Richards, Raphael Bueno, Charles H. Yoon, Juan Miret, Meenhard Herlyn, Levi A. Garraway, Eliezer M. Van Allen, Gordon J. Freeman, Paul T. Kirschmeier, Jochen H. Lorch, Patrick A. Ott, F. Stephen Hodi, Keith T. Flaherty, Roger D. Kamm, Genevieve M. Boland, Kwok-Kin Wong, David Dornan, Cloud Peter Paweletz, David A. Barbie
Journal: Cancer Discovery
Cancer Discov (2018) 8 (2): 196–215.
https://doi.org/10.1158/2159-8290.CD-17-0833
Published: 04 February 2018
View articletitled, Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids
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Includes: Multimedia, Supplementary data
Journal Articles

A Unified Approach to Targeting the Lysosome's Degradative and Growth Signaling Roles

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Vito W. Rebecca, Michael C. Nicastri, Noel McLaughlin, Colin Fennelly, Quentin McAfee, Amruta Ronghe, Michel Nofal, Chun-Yan Lim, Eric Witze, Cynthia I. Chude, Gao Zhang, Gretchen M. Alicea, Shengfu Piao, Sengottuvelan Murugan, Rani Ojha, Samuel M. Levi, Zhi Wei, Julie S. Barber-Rotenberg, Maureen E. Murphy, Gordon B. Mills, Yiling Lu, Joshua Rabinowitz, Ronen Marmorstein, Qin Liu, Shujing Liu, Xiaowei Xu, Meenhard Herlyn, Roberto Zoncu, Donita C. Brady, David W. Speicher, Jeffrey D. Winkler, Ravi K. Amaravadi
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2017) 7 (11): 1266–1283.
https://doi.org/10.1158/2159-8290.CD-17-0741
Published: 01 November 2017
View articletitled, A Unified Approach to Targeting the Lysosome's Degradative and Growth Signaling Roles
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Includes: Supplementary data
Journal Articles

CDKN2B Loss Promotes Progression from Benign Melanocytic Nevus to Melanoma

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Andrew S. McNeal, Kevin Liu, Vihang Nakhate, Christopher A. Natale, Elizabeth K. Duperret, Brian C. Capell, Tzvete Dentchev, Shelley L. Berger, Meenhard Herlyn, John T. Seykora, Todd W. Ridky
Journal: Cancer Discovery
Cancer Discov (2015) 5 (10): 1072–1085.
https://doi.org/10.1158/2159-8290.CD-15-0196
Published: 30 September 2015
View articletitled, CDKN2B Loss Promotes Progression from Benign Melanocytic Nevus to Melanoma
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Includes: Supplementary data
Journal Articles

Hypoxia Induces Phenotypic Plasticity and Therapy Resistance in Melanoma via the Tyrosine Kinase Receptors ROR1 and ROR2

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Michael P. O'Connell, Katie Marchbank, Marie R. Webster, Alexander A. Valiga, Amanpreet Kaur, Adina Vultur, Ling Li, Meenhard Herlyn, Jessie Villanueva, Qin Liu, Xiangfan Yin, Sandy Widura, Janelle Nelson, Nivia Ruiz, Tura C. Camilli, Fred E. Indig, Keith T. Flaherty, Jennifer A. Wargo, Dennie T. Frederick, Zachary A. Cooper, Suresh Nair, Ravi K. Amaravadi, Lynn M. Schuchter, Giorgos C. Karakousis, Wei Xu, Xiaowei Xu, Ashani T. Weeraratna
Journal: Cancer Discovery
Cancer Discov (2013) 3 (12): 1378–1393.
https://doi.org/10.1158/2159-8290.CD-13-0005
Published: 01 December 2013
View articletitled, Hypoxia Induces Phenotypic Plasticity and Therapy Resistance in Melanoma via the Tyrosine Kinase Receptors ROR1 and ROR2
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Includes: Supplementary data
Journal Articles

Paracrine Signaling between Carcinoma Cells and Mesenchymal Stem Cells Generates Cancer Stem Cell Niche via Epithelial–Mesenchymal Transition

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Kati Räsänen, Meenhard Herlyn
Journal: Cancer Discovery
Cancer Discov (2012) 2 (9): 775–777.
https://doi.org/10.1158/2159-8290.CD-12-0312
Published: 10 September 2012
View articletitled, Paracrine Signaling between Carcinoma Cells and Mesenchymal Stem Cells Generates Cancer Stem Cell Niche via Epithelial–Mesenchymal Transition
Open the PDF for Paracrine Signaling between Carcinoma Cells and Mesenchymal Stem Cells Generates Cancer Stem Cell Niche via Epithelial–Mesenchymal Transition in another window