1-7 of 7
Mathew J. Garnett
Close
Save search
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles

Novel WRN Helicase Inhibitors Selectively Target Microsatellite-Unstable Cancer Cells

Gabriele Picco, Yanhua Rao, Angham Al Saedi, Yang Lee, Sara F. Vieira, Shriram Bhosle, Kieron May, Carmen Herranz-Ors, Samantha J. Walker, Raynold Shenje, Cansu Dincer, Freddy Gibson, Ruby Banerjee, Zoe Hewitson, Thilo Werner, Joshua E. Cottom, Yang Peng, Nanhua Deng, Youyou Zhang, Eldridge N. Nartey, Leng Nickels, Philip Landis, Daniela Conticelli, Katrina McCarten, Jacob Bush, Mamta Sharma, Howard Lightfoot, David House, Emma Milford, Emma K. Grant, Michal P. Glogowski, Craig D. Wagner, Marcus Bantscheff, Anna Rutkowska-Klute, Cell Model Network UK Group, Francesca Zappacosta, Jonathan Pettinger, Syd Barthorpe, H. Christian Eberl, Brian T. Jones, Jessica L. Schneck, Dennis J. Murphy, Emile E. Voest, Joshua P. Taygerly, Michael P. DeMartino, Matthew A. Coelho, Jonathan Houseley, Geeta Sharma, Benjamin Schwartz, Mathew J. Garnett
Journal: Cancer Discovery
Cancer Discov (2024) 14 (8): 1457–1475.
https://doi.org/10.1158/2159-8290.CD-24-0052
Published: 02 August 2024
View articletitled, Novel WRN Helicase Inhibitors Selectively Target Microsatellite-Unstable Cancer Cells
Open the PDF for Novel WRN Helicase Inhibitors Selectively Target Microsatellite-Unstable Cancer Cells in another window
Includes: Supplementary data
Journal Articles

Large-scale Pan-cancer Cell Line Screening Identifies Actionable and Effective Drug Combinations

Azadeh C. Bashi, Elizabeth A. Coker, Krishna C. Bulusu, Patricia Jaaks, Claire Crafter, Howard Lightfoot, Marta Milo, Katrina McCarten, David F. Jenkins, Dieudonne van der Meer, James T. Lynch, Syd Barthorpe, Courtney L. Andersen, Simon T. Barry, Alexandra Beck, Justin Cidado, Jacob A. Gordon, Caitlin Hall, James Hall, Iman Mali, Tatiana Mironenko, Kevin Mongeon, James Morris, Laura Richardson, Paul D. Smith, Omid Tavana, Charlotte Tolley, Frances Thomas, Brandon S. Willis, Wanjuan Yang, Mark J. O'Connor, Ultan McDermott, Susan E. Critchlow, Lisa Drew, Stephen E. Fawell, Jerome T. Mettetal, Mathew J. Garnett
Journal: Cancer Discovery
Cancer Discov (2024) 14 (5): 846–865.
https://doi.org/10.1158/2159-8290.CD-23-0388
Published: 01 May 2024
View articletitled, Large-scale Pan-cancer Cell Line Screening Identifies Actionable and Effective Drug Combinations
Open the PDF for Large-scale Pan-cancer Cell Line Screening Identifies Actionable and Effective Drug Combinations in another window
Includes: Supplementary data
Journal Articles

Can Drug Repurposing Accelerate Precision Oncology?

Luuk J. Schipper, Laurien J. Zeverijn, Mathew J. Garnett, Emile E. Voest
Journal: Cancer Discovery
Cancer Discov (2022) 12 (7): 1634–1641.
https://doi.org/10.1158/2159-8290.CD-21-0612
Published: 06 July 2022
View articletitled, Can Drug Repurposing Accelerate Precision Oncology?
Open the PDF for Can Drug Repurposing Accelerate Precision Oncology? in another window
Journal Articles

Werner Helicase Is a Synthetic-Lethal Vulnerability in Mismatch Repair–Deficient Colorectal Cancer Refractory to Targeted Therapies, Chemotherapy, and Immunotherapy

Gabriele Picco, Chiara M. Cattaneo, Esmée J. van Vliet, Giovanni Crisafulli, Giuseppe Rospo, Sarah Consonni, Sara F. Vieira, Iñigo Sánchez Rodríguez, Carlotta Cancelliere, Ruby Banerjee, Luuk J. Schipper, Daniele Oddo, Krijn K. Dijkstra, Jindrich Cinatl, Martin Michaelis, Fengtang Yang, Federica Di Nicolantonio, Andrea Sartore-Bianchi, Salvatore Siena, Sabrina Arena, Emile E. Voest, Alberto Bardelli, Mathew J. Garnett
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2021) 11 (8): 1923–1937.
https://doi.org/10.1158/2159-8290.CD-20-1508
Published: 01 August 2021
View articletitled, Werner Helicase Is a Synthetic-Lethal Vulnerability in Mismatch Repair–Deficient Colorectal Cancer Refractory to Targeted Therapies, Chemotherapy, and Immunotherapy
Open the PDF for Werner Helicase Is a Synthetic-Lethal Vulnerability in Mismatch Repair–Deficient Colorectal Cancer Refractory to Targeted Therapies, Chemotherapy, and Immunotherapy in another window
Includes: Supplementary data
Journal Articles

A Road Map for Precision Cancer Medicine Using Personalized Models

Gabriele Picco, Mathew J. Garnett
Journal: Cancer Discovery
Cancer Discov (2017) 7 (5): 456–458.
https://doi.org/10.1158/2159-8290.CD-17-0268
Published: 30 April 2017
View articletitled, A Road Map for Precision Cancer Medicine Using Personalized Models
Open the PDF for A Road Map for Precision Cancer Medicine Using Personalized Models in another window
Journal Articles

Isocitrate Dehydrogenase Mutations Confer Dasatinib Hypersensitivity and SRC Dependence in Intrahepatic Cholangiocarcinoma

Supriya K. Saha, John D. Gordan, Benjamin P. Kleinstiver, Phuong Vu, Mortada S. Najem, Jia-Chi Yeo, Lei Shi, Yasutaka Kato, Rebecca S. Levin, James T. Webber, Leah J. Damon, Regina K. Egan, Patricia Greninger, Ultan McDermott, Mathew J. Garnett, Roger L. Jenkins, Kimberly M. Rieger-Christ, Travis B. Sullivan, Aram F. Hezel, Andrew S. Liss, Yusuke Mizukami, Lipika Goyal, Cristina R. Ferrone, Andrew X. Zhu, J. Keith Joung, Kevan M. Shokat, Cyril H. Benes, Nabeel Bardeesy
Journal: Cancer Discovery
Cancer Discov (2016) 6 (7): 727–739.
https://doi.org/10.1158/2159-8290.CD-15-1442
Published: 30 June 2016
View articletitled, Isocitrate Dehydrogenase Mutations Confer Dasatinib Hypersensitivity and SRC Dependence in Intrahepatic Cholangiocarcinoma
Open the PDF for Isocitrate Dehydrogenase Mutations Confer Dasatinib Hypersensitivity and SRC Dependence in Intrahepatic Cholangiocarcinoma in another window
Includes: Supplementary data
Journal Articles

Mcl-1 and FBW7 Control a Dominant Survival Pathway Underlying HDAC and Bcl-2 Inhibitor Synergy in Squamous Cell Carcinoma

Lei He, Kristine Torres-Lockhart, Nicole Forster, Saranya Ramakrishnan, Patricia Greninger, Mathew J. Garnett, Ultan McDermott, Stephen M. Rothenberg, Cyril H. Benes, Leif W. Ellisen
Journal: Cancer Discovery
Cancer Discov (2013) 3 (3): 324–337.
https://doi.org/10.1158/2159-8290.CD-12-0417
Published: 07 March 2013
View articletitled, Mcl-1 and FBW7 Control a Dominant Survival Pathway Underlying HDAC and Bcl-2 Inhibitor Synergy in Squamous Cell Carcinoma
Open the PDF for Mcl-1 and FBW7 Control a Dominant Survival Pathway Underlying HDAC and Bcl-2 Inhibitor Synergy in Squamous Cell Carcinoma in another window
Includes: Supplementary data