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Maria Jure-Kunkel
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Journal Articles

Preclinical Characterization and Phase I Trial Results of a Bispecific Antibody Targeting PD-L1 and 4-1BB (GEN1046) in Patients with Advanced Refractory Solid Tumors

Open Access
Alexander Muik, Elena Garralda, Isil Altintas, Friederike Gieseke, Ravit Geva, Eytan Ben-Ami, Corinne Maurice-Dror, Emiliano Calvo, Patricia M. LoRusso, Guzman Alonso, Maria E. Rodriguez-Ruiz, Kristina B. Schoedel, Jordan M. Blum, Bianca Sänger, Theodora W. Salcedo, Saskia M. Burm, Eliana Stanganello, Dennis Verzijl, Fulvia Vascotto, Angelica Sette, Juliane Quinkhardt, Theo S. Plantinga, Aras Toker, Edward N. van den Brink, Mark Fereshteh, Mustafa Diken, David Satijn, Sebastian Kreiter, Esther C.W. Breij, Gaurav Bajaj, Eleni Lagkadinou, Kate Sasser, Özlem Türeci, Ulf Forssmann, Tahamtan Ahmadi, Uğur Şahin, Maria Jure-Kunkel, Ignacio Melero
Journal: Cancer Discovery
Cancer Discov (2022) 12 (5): 1248–1265.
https://doi.org/10.1158/2159-8290.CD-21-1345
Published: 02 May 2022
View article titled, Preclinical Characterization and Phase I Trial Results of a Bispecific Antibody Targeting PD-L1 and 4-1BB (GEN1046) in Patients with Advanced Refractory Solid Tumors
Open the PDF for Preclinical Characterization and Phase I Trial Results of a Bispecific Antibody Targeting PD-L1 and 4-1BB (GEN1046) in Patients with Advanced Refractory Solid Tumors in another window
Includes: Supplementary data
Journal Articles

Resistance to Durvalumab and Durvalumab plus Tremelimumab Is Associated with Functional STK11 Mutations in Patients with Non–Small Cell Lung Cancer and Is Reversed by STAT3 Knockdown

Open Access
Nabendu Pore, Song Wu, Nathan Standifer, Maria Jure-Kunkel, Melissa de los Reyes, Yashaswi Shrestha, Rebecca Halpin, Raymond Rothstein, Kathy Mulgrew, Stephen Blackmore, Philip Martin, John Meekin, III, Matthew Griffin, Ina Bisha, Theresa A. Proia, Ricardo J. Miragaia, Ronald Herbst, Ashok Gupta, Shaad E. Abdullah, Rajiv Raja, Melanie M. Frigault, J. Carl Barrett, Phillip A. Dennis, Maria Libera Ascierto, Michael D. Oberst
Journal: Cancer Discovery
Cancer Discov (2021) 11 (11): 2828–2845.
https://doi.org/10.1158/2159-8290.CD-20-1543
Published: 01 November 2021
View article titled, Resistance to Durvalumab and Durvalumab plus Tremelimumab Is Associated with Functional STK11 Mutations in Patients with Non–Small Cell Lung Cancer and Is Reversed by STAT3 Knockdown
Open the PDF for Resistance to Durvalumab and Durvalumab plus Tremelimumab Is Associated with Functional STK11 Mutations in Patients with Non–Small Cell Lung Cancer and Is Reversed by STAT3 Knockdown in another window
Includes: Supplementary data
Journal Articles

Cancer Immunotherapy with Immunomodulatory Anti-CD137 and Anti–PD-1 Monoclonal Antibodies Requires BATF3-Dependent Dendritic Cells

Free
Alfonso R. Sánchez-Paulete, Francisco J. Cueto, María Martínez-López, Sara Labiano, Aizea Morales-Kastresana, María E. Rodríguez-Ruiz, Maria Jure-Kunkel, Arantza Azpilikueta, M. Angela Aznar, José I. Quetglas, David Sancho, Ignacio Melero
Journal: Cancer Discovery
Cancer Discov (2016) 6 (1): 71–79.
https://doi.org/10.1158/2159-8290.CD-15-0510
Published: 07 January 2016
View article titled, Cancer Immunotherapy with Immunomodulatory Anti-CD137 and Anti–PD-1 Monoclonal Antibodies Requires BATF3-Dependent Dendritic Cells
Open the PDF for Cancer Immunotherapy with Immunomodulatory Anti-CD137 and Anti–PD-1 Monoclonal Antibodies Requires BATF3-Dependent Dendritic Cells in another window
Includes: Supplementary data
Journal Articles

The HIF-1α Hypoxia Response in Tumor-Infiltrating T Lymphocytes Induces Functional CD137 (4-1BB) for Immunotherapy

Free
Asís Palazón, Iván Martínez-Forero, Alvaro Teijeira, Aizea Morales-Kastresana, Carlos Alfaro, Miguel F. Sanmamed, Jose Luis Perez-Gracia, Iván Peñuelas, Sandra Hervás-Stubbs, Ana Rouzaut, Manuel Ortiz de Landázuri, Maria Jure-Kunkel, Julian Aragonés, Ignacio Melero
Journal: Cancer Discovery
Cancer Discov (2012) 2 (7): 608–623.
https://doi.org/10.1158/2159-8290.CD-11-0314
Published: 10 July 2012
View article titled, The HIF-1α Hypoxia Response in Tumor-Infiltrating T Lymphocytes Induces Functional CD137 (4-1BB) for Immunotherapy
Open the PDF for The HIF-1α Hypoxia Response in Tumor-Infiltrating T Lymphocytes Induces Functional CD137 (4-1BB) for Immunotherapy in another window
Includes: Supplementary data