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Marco Ruella
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Journal Articles

Modulation of BCL-2 in Both T Cells and Tumor Cells to Enhance Chimeric Antigen Receptor T-cell Immunotherapy against Cancer

Yong Gu Lee, Puneeth Guruprasad, Guido Ghilardi, Raymone Pajarillo, Christopher Tor Sauter, Ruchi Patel, Hatcher J. Ballard, Seok Jae Hong, Inkook Chun, Nicholas Yang, Kimberly V. Amelsberg, Katherine D. Cummins, Jakub Svoboda, Saar Gill, Elise A. Chong, Khrystyna North, Sarah E. Church, Joseph A. Fraietta, Wan-Jung Chang, Simon F. Lacey, Xueqing Maggie Lu, Yunlin Zhang, Kanupriya Whig, David C. Schultz, Sara Cherry, James Gerson, Stephen J. Schuster, Patrizia Porazzi, Marco Ruella
Journal: Cancer Discovery
Cancer Discov (2022) 12 (10): 2372–2391.
https://doi.org/10.1158/2159-8290.CD-21-1026
Published: 05 October 2022
View articletitled, Modulation of BCL-2 in Both T Cells and Tumor Cells to Enhance Chimeric Antigen Receptor T-cell Immunotherapy against Cancer
Open the PDF for Modulation of BCL-2 in Both T Cells and Tumor Cells to Enhance Chimeric Antigen Receptor T-cell Immunotherapy against Cancer in another window
Includes: Supplementary data
Journal Articles

Impaired Death Receptor Signaling in Leukemia Causes Antigen-Independent Resistance by Inducing CAR T-cell Dysfunction

Nathan Singh, Yong Gu Lee, Olga Shestova, Pranali Ravikumar, Katharina E. Hayer, Seok Jae Hong, Xueqing Maggie Lu, Raymone Pajarillo, Sangya Agarwal, Shunichiro Kuramitsu, Elena J. Orlando, Karen Thudium Mueller, Charly R. Good, Shelley L. Berger, Ophir Shalem, Matthew D. Weitzman, Noelle V. Frey, Shannon L. Maude, Stephan A. Grupp, Carl H. June, Saar Gill, Marco Ruella
Journal: Cancer Discovery
Cancer Discov (2020) 10 (4): 552–567.
https://doi.org/10.1158/2159-8290.CD-19-0813
Published: 01 April 2020
View articletitled, Impaired Death Receptor Signaling in Leukemia Causes Antigen-Independent Resistance by Inducing CAR T-cell Dysfunction
Open the PDF for Impaired Death Receptor Signaling in Leukemia Causes Antigen-Independent Resistance by Inducing CAR T-cell Dysfunction in another window
Includes: Supplementary data
Journal Articles

Overcoming the Immunosuppressive Tumor Microenvironment of Hodgkin Lymphoma Using Chimeric Antigen Receptor T Cells

Marco Ruella, Michael Klichinsky, Saad S. Kenderian, Olga Shestova, Amy Ziober, Daniel O. Kraft, Michael Feldman, Mariusz A. Wasik, Carl H. June, Saar Gill
Journal: Cancer Discovery
Cancer Discov (2017) 7 (10): 1154–1167.
https://doi.org/10.1158/2159-8290.CD-16-0850
Published: 02 October 2017
View articletitled, Overcoming the Immunosuppressive Tumor Microenvironment of Hodgkin Lymphoma Using Chimeric Antigen Receptor T Cells
Open the PDF for Overcoming the Immunosuppressive Tumor Microenvironment of Hodgkin Lymphoma Using Chimeric Antigen Receptor T Cells in another window
Includes: Supplementary data
Journal Articles

Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy

Elena Sotillo, David M. Barrett, Kathryn L. Black, Asen Bagashev, Derek Oldridge, Glendon Wu, Robyn Sussman, Claudia Lanauze, Marco Ruella, Matthew R. Gazzara, Nicole M. Martinez, Colleen T. Harrington, Elaine Y. Chung, Jessica Perazzelli, Ted J. Hofmann, Shannon L. Maude, Pichai Raman, Alejandro Barrera, Saar Gill, Simon F. Lacey, Jan J. Melenhorst, David Allman, Elad Jacoby, Terry Fry, Crystal Mackall, Yoseph Barash, Kristen W. Lynch, John M. Maris, Stephan A. Grupp, Andrei Thomas-Tikhonenko
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2015) 5 (12): 1282–1295.
https://doi.org/10.1158/2159-8290.CD-15-1020
Published: 03 December 2015
View articletitled, Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy
Open the PDF for Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy in another window
Includes: Supplementary data